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Polymers in Tissue Regeneration and Antimicrobial Strategies: Innovations and Applications

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: 31 October 2026 | Viewed by 472

Editors

Biological Science and Medical Engineering, Donghua University, Shanghai, China
Interests: hydrogel; polymer, enzyme; tissue regeneration; antibacterial; nanomedicine

Special Issue Information

Dear Colleagues,

Polymers have become indispensable cornerstones in tissue regeneration and antimicrobial medicines. Their tailor-made architectures, excellent biocompatibility, and intrinsic capacity for multifunctional synergy now provide a transformative platform that can simultaneously reconstruct complex tissue defects and thwart microbial threats. This Special Issue spotlights convergent innovations where polymer science meets regenerative medicine and antimicrobial strategies. Topics span biodegradable scaffolds that orchestrate the cellular microenvironment, smart stimuli-responsive systems for the on-demand delivery of bioactive cues, surface-functionalized polymers that erect antimicrobial barriers, and green polymer platforms derived from natural or sustainable feedstocks. We invite contributions that advance polymer synthesis and micro-/nano-structural characterization, elucidate cell–material–microbe interfacial mechanisms, and co-design antimicrobial and pro-regenerative functions, showcasing cutting-edge progress from fundamental discovery to clinical translation. Collectively, these works will highlight the fertile frontier created by the fusion of polymer science and biomedicine.

Dr. Alberto Falco
Dr. Ling Ding
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polymers
  • tissue regeneration
  • antimicrobial
  • scaffolds
  • cell–material–microbe interfacial

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Published Papers (1 paper)

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Review

24 pages, 3738 KB  
Review
Poly(methyl vinyl ether-alt-maleic anhydride) and Its Derivatives: From Polymer Synthesis to Advanced Biomedical Applications
by Pedro Valentín Badía-Hernández, Rocío Díaz-Puertas, Paula del Carmen Sánchez-García, Alberto Falcó, Pilar García-Morales and Ricardo Mallavia
Polymers 2026, 18(13), 1667; https://doi.org/10.3390/polym18131667 - 6 Jul 2026
Abstract
Poly(methyl vinyl ether-alt-maleic anhydride) (PMVEMA) is a versatile synthetic copolymer that has gained considerable attention in biomedical and pharmaceutical applications due to its biocompatibility, biodegradability, bioadhesive properties and chemical reactivity. This review summarizes the current knowledge regarding the derivatives, physicochemical properties, [...] Read more.
Poly(methyl vinyl ether-alt-maleic anhydride) (PMVEMA) is a versatile synthetic copolymer that has gained considerable attention in biomedical and pharmaceutical applications due to its biocompatibility, biodegradability, bioadhesive properties and chemical reactivity. This review summarizes the current knowledge regarding the derivatives, physicochemical properties, functionalization and crosslinking strategies of PMVEMA, with particular emphasis on their relevance to biomedical applications. A comprehensive literature analysis was performed using major scientific databases, combined with artificial intelligence-assisted text mining, to identify the principal research trends associated with PMVEMA. The reviewed studies demonstrate that the reactive anhydride groups of PMVEMA enable the formation of a wide variety of derivatives, including hydrogels, nanoparticles and nanofibers with tunable properties. These characteristics have facilitated its application in different fields, including immunology, drug delivery, dentistry and dermatology. In particular, PMVEMA-based systems exhibit enhanced mucosal adhesion, controlled drug release, immunoadjuvant activity and biocompatibility in vitro and in vivo. Despite its broad applicability, further studies are still needed to fully elucidate its biodegradation mechanisms in vivo and optimize its clinical translation. Full article
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