Challenges of Technology and Processing for Plant Extraction

A special issue of Plants (ISSN 2223-7747). This special issue belongs to the section "Phytochemistry".

Deadline for manuscript submissions: 20 November 2025 | Viewed by 464

Special Issue Editors


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Guest Editor
NOVA School of Science and Technology, NOVA University Lisbon, Caparica, Portugal
Interests: pharmaceutical engineering; sustainable chemistry, green extraction technologies; green solvents (supercritical carbon dioxide, subcritical water, ultrasound- and microwave-assisted extraction), physical-chemical, biochemical, and pharmacological analyses; valorization of (food, agricultural, industry, marine, communal) waste and by-products by applying green engineering
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Guest Editor
Department of Pharmaceutical Engineering, University of Novi Sad, 21000 Novi Sad, Serbia
Interests: green extraction processes; bioactive compounds; valorization of by-products of the food industry; valorization of agricultural waste
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

With the growing global emphasis on sustainability, plant extracts must be obtained through environmentally responsible methods to support advancements in pharmaceuticals, cosmetics, food, and nutraceuticals. However, conventional extraction techniques often face challenges related to efficiency, selectivity, environmental sustainability, and scalability. This Special Issue explores innovative approaches to plant extraction, with a focus on overcoming technological and processing limitations. Emphasis will be placed on green solvents, advanced extraction technologies, process optimization, and biorefinery integration. Contributions addressing the scale-up of extraction processes, regulatory considerations, and sustainability assessments are also welcome. By bringing together interdisciplinary research, this Special Issue aims to highlight novel methodologies that enhance extraction efficiency, improve bioactive compound recovery, and reduce environmental impact. The findings will contribute to advancing plant extraction technologies, ensuring their industrial feasibility while aligning with the principles of green chemistry and the circular economy.

Key topics

This Special Issue invites original research articles, reviews, and perspectives on, but not limited to, the following topics:

  • Green solvents and extraction techniques;
  • Supercritical fluid extraction;
  • Subcritical water extraction;
  • Ultrasound-assisted extraction;
  • Microwave-assisted extraction;
  • Deep eutectic solvents;
  • Ionic liquids;
  • Solvent-free extractions;
  • Process optimization and modeling;
  • Biorefinery and waste valorization;
  • Advances in solvent systems;
  • Challenges in industrial scale-up.

Dr. Jelena Vladić
Dr. Nataša Nastić
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Plants is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • plant extracts
  • extraction techniques
  • green solvents
  • bioactive compounds

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Published Papers (1 paper)

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Research

19 pages, 1195 KiB  
Article
High-Voltage Electrical Discharge Extraction of Polyphenols from Winter Savory (Satureja montana L.): Antioxidant Assessment and Chemometric Interpretation
by Kristian Pastor, Nataša Nastić, Aleksandra Gavarić, Siniša Simić, Ante Lončarić, Marija Banožić, Krunoslav Aladić, Stela Jokić and Jelena Vladić
Plants 2025, 14(14), 2214; https://doi.org/10.3390/plants14142214 - 17 Jul 2025
Viewed by 318
Abstract
This study investigated the potential of high-voltage electrical discharge (HVED), as a green, non-thermal extraction technology, for recovering polyphenols from winter savory (Satureja montana L.). Key process parameters, including frequency (40, 70, 100 Hz) and extraction time (1, 5, 15, 30, 45 [...] Read more.
This study investigated the potential of high-voltage electrical discharge (HVED), as a green, non-thermal extraction technology, for recovering polyphenols from winter savory (Satureja montana L.). Key process parameters, including frequency (40, 70, 100 Hz) and extraction time (1, 5, 15, 30, 45 min), were optimized, using water as a solvent and maintaining a constant solid-to-liquid ratio of 1:100 g/mL. The extracts were characterized for total polyphenol content (TPC), total flavonoid content (TFC), and antioxidant activity (DPPH, ABTS, FRAP), while individual phenolics were quantified via HPLC-DAD. Multivariate chemometric analyses, including Pearson correlation, heatmap clustering, and principal component analysis (PCA), were employed to reveal relationships between extraction conditions, polyphenolic profiles, and antioxidant activities. The results showed strong correlations between TPC, TFC, and antioxidant activity, with compounds such as quercetin-3-D-galactoside, procyanidin A2, and rutin identified as key contributors. Among the tested conditions, extraction at 70 Hz for 45 min provided the highest polyphenol yield and bioactivity. The application of HVED demonstrated its potential as an efficient and environmentally friendly technique for obtaining phenolic-rich extracts. In addition, the use of chemometric tools provided useful insights for optimizing extraction conditions and understanding the contributions of specific compounds to bioactivity. These results support future applications in clean-label product development and contribute to broader efforts in sustainable ingredient production for the food, cosmetic, and nutraceutical sectors. Full article
(This article belongs to the Special Issue Challenges of Technology and Processing for Plant Extraction)
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