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Plants
Special Issues
Chemical Composition and Biological Activity of Plant Essential Oil
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Chemical Composition and Biological Activity of Plant Essential Oil

A special issue of Plants (ISSN 2223-7747). This special issue belongs to the section "Phytochemistry".

Deadline for manuscript submissions: closed (31 December 2025) | Viewed by 1126

Special Issue Editors

Dr. Ivana Carev

E-Mail Website
Guest Editor
Department of Analytical and Environmental Chemistry, Faculty of Chemistry and Technology, University of Split, Ruđera Boškovića 35, 21000 Split, Croatia
Interests: antibacterial activity; biological activity; chemistry; phytochemistry; natural products; essential oils; medicinal and aromatic plants; natural products chemistry; molecular mechanisms of bioactivity; molecular docking and modelling; structure–activity relationships (SARs); drug discovery and design
Special Issues, Collections and Topics in MDPI journals
Dr. Sylwia Zielińska

E-Mail Website
Guest Editor
Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Wroclaw Medical University, 50-556 Wroclaw, Poland
Interests: plant biotechnology; plant in vitro cultures; phytochemistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The Special Issue "Chemical Composition and Biological Activity of Plant Essential Oils" focuses on exploring the diverse chemical profiles and bioactivities of essential oils derived from plants. Due to their complex chemical mixtures of volatile compounds, essential oils can exhibit a wide range of biological properties, such as antimicrobial, antiviral, antioxidant, anti-inflammatory, cytotoxic, and anticancer activities. This issue aims to highlight recent advancements in the identification and characterization of essential oil chemical components using state-of-the-art analytical techniques, such as gas chromatography-mass spectrometry (GC-MS). Additionally, it seeks to examine the therapeutic potential of essential oils, as well as their applications in medicine, cosmetics, agriculture, and food preservation, among others. By emphasizing interdisciplinary research, this issue provides insights into the chemical diversity of essential oils and their practical uses, fostering a deeper understanding of their role in natural product science and sustainable development of various products.

Dr. Ivana Carev
Dr. Sylwia Zielińska
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Plants is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • essential oils
  • chemical composition
  • biological activity
  • GC-MS analysis
  • natural products

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Published Papers (1 paper)

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Research

17 pages, 2626 KB  
Article
Comprehensive Evaluation of Vacrol Oil Combination in Experimental Wound Healing: From Phytochemical Analysis to Functional and Structural Repair
by Esra Küpeli Akkol and Didem Deliorman Orhan
Plants 2025, 14(22), 3547; https://doi.org/10.3390/plants14223547 - 20 Nov 2025
Viewed by 741
Abstract
Wound healing is a complex biological process involving overlapping phases of inflammation, proliferation, and remodeling. Plant-derived agents have gained attention as alternatives or adjuncts to synthetic drugs owing to their accessibility and favorable safety profile. This study evaluated the wound-healing activity of Vacrol [...] Read more.
Wound healing is a complex biological process involving overlapping phases of inflammation, proliferation, and remodeling. Plant-derived agents have gained attention as alternatives or adjuncts to synthetic drugs owing to their accessibility and favorable safety profile. This study evaluated the wound-healing activity of Vacrol Oil Combination (VOC), a phytotherapeutic preparation, through in vivo wound models and in vitro enzyme inhibition assays. Linear incision wounds in rats and circular excision wounds in mice were treated with VOC, administered orally, topically, or in combination for 10 days. Experimental groups included a negative control (no treatment), a vehicle control (olive oil), VOC-treated groups, and a reference group treated with 0.2% nitrofurazone. Wound contraction, tensile strength, histopathology, and hydroxyproline levels were assessed. In vitro assays were conducted to evaluate the inhibitory effects of VOC on hyaluronidase, collagenase, and elastase. VEGF and TGF-β1 levels were measured to assess the involvement of growth factors in the healing process. The chemical composition of VOC was characterized by gas chromatography–mass spectrometry (GC–MS), which identified carvacrol as the major compound, together with 1,8-cineole, linalool, eugenol, and cinnamaldehyde as prominent constituents known for their anti-inflammatory and antioxidant activities. VOC treatment significantly enhanced wound contraction and tensile strength compared to controls, with the oral + topical group showing the highest efficacy. Hydroxyproline levels and histological findings confirmed improved collagen synthesis and tissue regeneration. GC–MS analysis identified carvacrol as the major constituent of VOC, along with eugenol and linalool, which are known for their anti-inflammatory and antioxidant effects. Furthermore, VOC increased tissue levels of VEGF and TGF-β1, suggesting a role in stimulating angiogenesis and extracellular matrix remodeling. These findings indicate that the phytoconstituents of VOC, particularly carvacrol and oxygenated terpenes, act synergistically to promote wound repair. VOC demonstrates strong potential as a complementary phytotherapeutic agent for wound management, warranting further clinical investigation. Full article
(This article belongs to the Special Issue Chemical Composition and Biological Activity of Plant Essential Oil)
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