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Natural Products in Plants: Isolation, Chemical Analysis and Bioactivity Evaluation
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Natural Products in Plants: Isolation, Chemical Analysis and Bioactivity Evaluation

A special issue of Plants (ISSN 2223-7747). This special issue belongs to the section "Phytochemistry".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 5571

Special Issue Editors

Prof. Dr. Lhou Majidi

E-Mail Website
Guest Editor
Chemistry Department, Faculty of Sciences and Techniques, Moulay Ismail University, Errachidia 52000, Morocco
Interests: phytochemistry; organic chemistry; biochemistry; analytical chemistry; environmental engineering; materials engineering; chemical engineering
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Jean Costa

E-Mail Website
Guest Editor
CNRS UMR 6134 SPE, Laboratory of Chemistry of Natural Products, University of Corsica, Corte, France
Interests: analytical chemistry; organic chemistry; phytochemistry; biochemistry

Special Issue Information

Dear Colleagues,

The immense advantage offered by perfume, aromatic and medicinal plants (PAMP) is that given the large number and great diversity of species made available in the flora as well as the great variety of chemical products that they contain, we are faced with an infinite number of natural chemical combinations that no chemical synthesis strategy in the laboratory can equal. In addition, the chemical constituents and their contents vary according to the part of the plant, the soil in which it grows, the moment of picking, the methods of drying, the conservation method, and the mode of extraction. The Mediterranean region, renowned for its specific climate, has a very diversified specific floristic richness that is not fully exploited today. This diversity, accentuated by the existence of spontaneous endemic species, constitutes a huge wealth of resources, provided, however, that the exploitation project is integrated into the local economic context.

This Special Issue aims to expand current knowledge related to natural products in Mediterranean plants, including isolation, chemical analysis and bioactivity assessment. It also offers an interdisciplinary platform for researchers from various backgrounds to communicate their latest scientific studies in the field of the isolation, characterization and biological activity of complex natural mixtures and pure components from the secondary metabolites of perfume aromatic and medicinal plants of the Mediterranean region. Innovative research on technologies and methodological approaches with PAMP is encouraged.

Prof. Dr. Lhou Majidi
Prof. Dr. Jean Costa
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Plants is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Mediterranean plants
  • perfume aromatic and medicinal plants
  • isolation methodologies
  • chemical analysis
  • secondary metabolites
  • bioactivity

Published Papers (3 papers)

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Research

11 pages, 646 KiB  
Article
Chemical Profiling, Insecticidal, and Phytotoxic Effect of Essential Oils from Leaves and Inflorescence of Moroccan Chenopodium ambrosioides (L.)
by Ayoub Kasrati, El Hassan Sakar, Ahmed Aljaiyash, Aziz Hirri, Lahcen Tamegart, Imane Abbad and Chaima Alaoui Jamali
Plants 2024, 13(4), 483; https://doi.org/10.3390/plants13040483 - 08 Feb 2024
Viewed by 806
Abstract
Chenopodium ambrosioides (L.) is a medicinal and aromatic plant widely used in the Moroccan traditional medicine for its important pharmacological properties. In order to contribute to the valorization of this plant, the current study aimed at evaluating, for the first time, the variation [...] Read more.
Chenopodium ambrosioides (L.) is a medicinal and aromatic plant widely used in the Moroccan traditional medicine for its important pharmacological properties. In order to contribute to the valorization of this plant, the current study aimed at evaluating, for the first time, the variation in the yield, chemical composition, and insecticidal and phytotoxic activities of C. ambrosioides essential oil (CAEO) isolated from leaves and inflorescences. The results obtained showed that the CAEO yields vary significantly according to the distilled plant part, with 0.75 ± 0.15% for the leaves and 1.2 ± 0.34% for the inflorescences. CAEO profiling showed quantitative more than qualitative differences. Leaf CAEO was rich in δ-3-carene (61.51%), followed by p-cymene (14.67%) and 1,2:3,4-diepoxy-p-menthane (6.19%). However, inflorescence CAEO was dominated by the same compounds but with variable levels (δ-3-Carene: 44.29%; 1,2:3,4-diepoxy-p-menthane: 19.46%; and p-cymene: 17.85%). The CAEOs from the leaves and inflorescences showed a very interesting inhibiting effect on the germination and growth of the three species used, namely Medicago sativa, Linum rusitatissimum, and Raphanus sativus. However, there was no significant difference between these CAEOs. Similarly, for the insecticidal activity, CAEOs exhibited an important and similar toxicity against Tribolium confusum adults with LD50 of 4.30 and 4.46 μL/L of air and LD90 of 6.51 and 9.62 μL/L air for toxicity by fumigation, while values for contact toxicity on filter paper were 0.04 and 0.05 μL/cm2 for LD50 and 0.08 and 0.09 μL/cm2 for LD90. Full article
(This article belongs to the Special Issue Natural Products in Plants: Isolation, Chemical Analysis and Bioactivity Evaluation)
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21 pages, 4381 KiB  
Article
GC/MS Profiling, Antibacterial, Anti-Quorum Sensing, and Antibiofilm Properties of Anethum graveolens L. Essential Oil: Molecular Docking Study and In-Silico ADME Profiling
by Emira Noumi, Iqrar Ahmad, Mohd Adnan, Abderrahmen Merghni, Harun Patel, Najla Haddaji, Nouha Bouali, Khulood Fahad Alabbosh, Siwar Ghannay, Kaïss Aouadi, Adel Kadri, Flavio Polito, Mejdi Snoussi and Vincenzo De Feo
Plants 2023, 12(10), 1997; https://doi.org/10.3390/plants12101997 - 16 May 2023
Cited by 13 | Viewed by 2134
Abstract
Anethum graveolens L. has been known as an aromatic, medicinal, and culinary herb since ancient times. The main purpose of this study was to determine the chemical composition, antibacterial, antibiofilm, and anti-quorum sensing activities of the essential oil (EO) obtained by hydro-distillation of [...] Read more.
Anethum graveolens L. has been known as an aromatic, medicinal, and culinary herb since ancient times. The main purpose of this study was to determine the chemical composition, antibacterial, antibiofilm, and anti-quorum sensing activities of the essential oil (EO) obtained by hydro-distillation of the aerial parts. Twelve components were identified, representing 92.55% of the analyzed essential oil. Limonene (48.05%), carvone (37.94%), cis-dihydrocarvone (3.5%), and trans-carvone (1.07%) were the main identified constituents. Results showed that the obtained EO was effective against eight bacterial strains at different degrees. Concerning the antibiofilm activity, limonene was more effective against biofilm formation than the essential oil when tested using sub-inhibitory concentrations. The results of anti-swarming activity tested against P. aeruginosa PAO1 revealed that A. graveolens induced more potent inhibitory effects in the swarming behavior of the PAO1 strain when compared to limonene, with a percentage reaching 33.33% at a concentration of 100 µg/mL. The ADME profiling of the identified phytocompounds confirms their important pharmacokinetic and drug-like properties. The in-silico study using molecular docking approaches reveals a high binding score between the identified compounds and known target enzymes involved in antibacterial and anti-quorum sensing (QS) activities. Overall, the obtained results highlight the possible use of A. graveolens EO to prevent food contamination with foodborne pathogenic bacteria. Full article
(This article belongs to the Special Issue Natural Products in Plants: Isolation, Chemical Analysis and Bioactivity Evaluation)
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13 pages, 322 KiB  
Article
The Type of Grain Counts: Effectiveness of Three Essential Oil-Based Nanoemulsions against Sitophilus oryzae
by Nickolas G. Kavallieratos, Giulia Bonacucina, Erifili P. Nika, Anna Skourti, Stavroula Kyriaki C. Georgakopoulou, Constantin S. Filintas, Anna Maria E. Panariti, Filippo Maggi, Riccardo Petrelli, Marta Ferrati, Eleonora Spinozzi, Diego Romano Perinelli, Angelo Canale and Giovanni Benelli
Plants 2023, 12(4), 813; https://doi.org/10.3390/plants12040813 - 11 Feb 2023
Cited by 6 | Viewed by 2059
Abstract
Essential oil (EO)-based nanoemulsions (NEs) are promising grain protectants in the management of stored-product pests. However, the potential impact of the stored-grain species on the green insecticide effectiveness has been poorly studied. In this study, two concentrations of EO-based NEs from Carlina acaulis [...] Read more.
Essential oil (EO)-based nanoemulsions (NEs) are promising grain protectants in the management of stored-product pests. However, the potential impact of the stored-grain species on the green insecticide effectiveness has been poorly studied. In this study, two concentrations of EO-based NEs from Carlina acaulis L., Mentha longifolia (L.) Huds., and Hazomalania voyronii (Jum.) Capuron were evaluated as insecticides against the major stored-product pest Sitophilus oryzae (L.) on barley, oats, and maize kernels. The C. acaulis EO-based NE applied at 1000 ppm on barley achieved the highest mortality, killing 94.4% of S. oryzae adults after a 7-day exposure, followed by 1000 ppm of H. voyronii EO-based NE (83.3%). The lowest mortality (1.1%) was recorded with 500 ppm of M. longifolia EO-based NE on maize after the same interval. All tested NEs exhibited elevated efficacy when applied on barley, while mortalities were lower on oats and maize. Furthermore, C. acaulis EO-based NE was the most effective when applied on all commodities, followed by H. voyronii and M. longifolia EO-based NEs. Overall, our results highlighted the significant impact of the stored cereal on the insecticidal effectiveness of EO-based NE used for stored-product pest control. Sitophilus oryzae adults on barley can be adequately controlled through the application of C. acaulis and H. voyronii EO-based NEs. Full article
(This article belongs to the Special Issue Natural Products in Plants: Isolation, Chemical Analysis and Bioactivity Evaluation)
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