Genome-Informed Molecular Targets, Pathogen Adaptation, and Antimicrobial Strategies in Plant Bacterial Diseases

A special issue of Plants (ISSN 2223-7747). This special issue belongs to the section "Plant Protection and Biotic Interactions".

Deadline for manuscript submissions: 30 April 2027 | Viewed by 98

Editors


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Guest Editor
College of Plant Protection, South China Agricultural University, Guangzhou 510642, China
Interests: citrus disease management

E-Mail Website
Guest Editor
Guangdong Province Key Laboratory of Microbial Signals and Disease Control, South China Agricultural University, Guangzhou 510642, China
Interests: citrus disease; huanglongbing (HLB)

Special Issue Information

Dear Colleagues,

Plant bacterial diseases, including citrus Huanglongbing, citrus canker, bacterial wilt, and fire blight, present severe threats to global agricultural sustainability, compounded by rapid pathogen adaptation and emerging resistance to chemical controls. While existing general platforms address broad crop management and host physiology, this Special Issue, titled “Genome-Informed Molecular Targets, Pathogen Adaptation, and Antimicrobial Strategies in Plant Bacterial Diseases,” focuses on the intersection of comparative pathogen genomics and mechanistic bacteriology. We invite original research, reviews, and perspectives that leverage genomic, transcriptomic, and evolutionary data to reveal virulence mechanisms, secretion system functions, structural genome variations, and molecular targets for next-generation control. Topics of interest are strictly centered on bacterial fitness and counter-adaptation, including the discovery of novel molecular targets, anti-virulence and anti-adaptation screening, mechanism-based biological control, and novel antimicrobial delivery systems. By focusing on the structural and functional biochemistry of the pathogen, this Special Issue provides a specialized home for precise, translationally driven bacteriology research distinct from generalized horticultural disease management.

Dr. Zheng Zheng
Prof. Dr. Xiaoling Deng
Guest Editors

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Keywords

  • citrus bacterial diseases
  • huanglongbing
  • Candidatus Liberibacter asiaticus
  • citrus canker
  • plant pathogenic bacteria
  • pathogen genomics
  • molecular targets
  • pathogen adaptation
  • virulence regulation
  • sustainable disease control

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Published Papers (1 paper)

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Review

31 pages, 20610 KB  
Review
Control Targets in Plant-Pathogenic Bacteria: From Growth-Essential Processes to Anti-Virulence Strategies and Candidate Targets in Candidatus Liberibacter Asiaticus
by Jinyin Zeng, Chenyu Huang, Yuxun Yu, Xiaobing Song, Meirong Xu, Xiaoling Deng, Bo Wang and Zheng Zheng
Plants 2026, 15(14), 2150; https://doi.org/10.3390/plants15142150 - 12 Jul 2026
Abstract
Plant-pathogenic bacteria threaten crop productivity and quality, yet chemical options remain limited compared with those for fungal and oomycete diseases. Current management relies mainly on copper bactericides, limited antibiotics, induced-resistance agents, biocontrol and resistant cultivars. However, copper and streptomycin resistance, efflux-mediated multidrug tolerance [...] Read more.
Plant-pathogenic bacteria threaten crop productivity and quality, yet chemical options remain limited compared with those for fungal and oomycete diseases. Current management relies mainly on copper bactericides, limited antibiotics, induced-resistance agents, biocontrol and resistant cultivars. However, copper and streptomycin resistance, efflux-mediated multidrug tolerance and rapid pathogen adaptation have weakened these strategies. Target-oriented research provides a framework for exploring agricultural antibacterials, anti-virulence agents, anti-colonization strategies, resistance sensitizers and host-resistance interventions, but many of these approaches remain conceptual, model-system, greenhouse or medical-bacteriology-derived rather than proven field solutions. This review classifies bacterial control targets into two interconnected groups: growth-essential targets, including peptidoglycan biosynthesis, membrane/envelope systems, nucleic-acid processes, protein synthesis, metabolism, nutrient transport and cell division; and anti-virulence/anti-adaptation targets, including secretion systems, quorum sensing, biofilms, motility, adhesion, cell-wall-degrading enzymes, tolerance systems, oxidative-stress responses and host susceptibility factors. Using “Candidatus Liberibacter asiaticus” (CLas) as a case study, genome annotation and infection-stage transcript-abundance data prioritized Sec-dependent secretion, outer-membrane/surface proteins, Bam assembly, nutrient transporters, Clp proteostasis, redox adaptation and core cellular processes as candidate target classes. Envelope-associated, secretion/anti-virulence, nutrient-acquisition and stress-sensitization modules may represent potential directions for downstream validation, but CLas candidates remain hypothesis-generating priorities requiring validation for essentiality, conservation, druggability, delivery feasibility, crop safety and field performance. Full article
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