Applications of Plant Physiology and Pharmacognosy in the Production of Bioactive Compounds

A special issue of Plants (ISSN 2223-7747).

Deadline for manuscript submissions: 31 July 2025 | Viewed by 549

Special Issue Editors


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Guest Editor
Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria
Interests: plant cell tissue and organ culture; medicinal and aromatic plants; conservation; secondary metabolites production; pharmacognosy; plant physiology; plant growth regulators
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Guest Editor
Department of Molecular Biology, Institute of Biology and Immunology of Reproduction, Acad. “Kiril Bratanov”, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria
Interests: medicinal plants; secondary metabolites production; natural products for cancer treatment
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to present the forthcoming Special Issue of the Plants journal entitled “Applications of Plant Physiology and Pharmacognosy in the Production of Bioactive Compounds”.

Over the centuries, despite traditional knowledge and up-to-date pharmacology research, the plant kingdom still remains one of the most widely utilized yet largely unstudied sources of active ingredients for sustaining human health. Starting with one of the oldest examples of aspirin discovery, utilizing antimalarial artemisinin, the application of numerous plant-derived pharmaceuticals, such as cardiac glycosides, cytostatics, spasmolytics, pain relief medication, etc., still remains irreplaceable in medicine.

Secondary metabolites are the biochemical tool of plant adaptation and survival and are produced in strong dependence on the fluctuating factors of the environment. They serve vital functions such as growth and development orchestration, the determent of herbivores, pollinator attraction, the induction of pathogen resistance and oxidative stress alleviation, amongst many other factors. Understanding the complexity and interplay between all these processes is the key to the successful production of plant-derived secondary metabolites through conventional breeding and biotechnological techniques. This knowledge is supported by the tools of plant physiology. On the other hand, pharmacognosy is the science of bringing together the knowledge of plant secondary metabolites production and accumulation in relation to species taxonomy and distribution, as well as the study of certain morphological features related to the production, accumulation and translocation of secondary metabolites within the plant organism. These two sciences bring together the knowledge of both the origin and functional understanding of plant-derived biologically active compounds.

We invite contributors of the many aspects of plant science to share their research in this journal. The Special Issue is an opportunity for researchers involved in the elucidation of biological activity, origin, structure and function related to bioactive plant-derived metabolites to present their work.

Dr. Kalina Danova
Dr. Elena N. Stoyanova
Guest Editors

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Keywords

  • medicinal and aromatic plants
  • biologically active plant metabolites
  • factors affecting plant bioactive metabolites production and accumulation
  • physiological role of primary and secondary metabolites in the plant organism
  • pharmacognostic knowledge of medicinal and aromatic plants
  • pharmacological activity of plant secondary metabolites

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Published Papers (1 paper)

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Research

22 pages, 517 KiB  
Article
Erica spiculifolia Salisb. (Balkan Heath): A Focus on Metabolic Profiling and Antioxidant and Enzyme Inhibitory Properties
by Reneta Gevrenova, Anna Szakiel, Cezary Pączkowski, Gokhan Zengin, Inci Kurt-Celep, Alexandra Stefanova and Dimitrina Zheleva-Dimitrova
Plants 2025, 14(11), 1648; https://doi.org/10.3390/plants14111648 - 28 May 2025
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Abstract
Erica spiculifolia Salisb. (formerly Bruckenthalia spiculifolia Benth.) (Balkan heath) is renowned for its traditional usage as a diuretic, anti-inflammatory and antioxidant agent. For the first time, acylquinic acids, flavonoids and numerous proanthocyanidin oligomers were annotated/dereplicated by liquid chromatography–high-resolution mass spectrometry in methanol–aqueous extracts [...] Read more.
Erica spiculifolia Salisb. (formerly Bruckenthalia spiculifolia Benth.) (Balkan heath) is renowned for its traditional usage as a diuretic, anti-inflammatory and antioxidant agent. For the first time, acylquinic acids, flavonoids and numerous proanthocyanidin oligomers were annotated/dereplicated by liquid chromatography–high-resolution mass spectrometry in methanol–aqueous extracts from E. spiculifolia aerial parts harvested at the early and full flowering stage. Chlorogenic acid and proanthocyanidin tetra- and trimer A, B-type together with quercitrin and (+) catechin were the predominant compounds in the semi-quantitative analysis. Neutral triterpenoids, triterpenoid acids and phytosterols were determined in apolar extracts by gas chromatography–mass spectrometry. Triterpenoid acids accounted for 80% of the total triterpenoid content, dominated by ursolic and oleanolic acid, reaching up to 32.2 and 6.1 mg/g dw, respectively. Ursa/olean-2,12-dien-28-oic acids and 3-keto-derivatives together with α-amyrin acetate as a chemotaxonomic marker, α-amyrenone, α- and β-amyrin were evaluated. Total phenolic and flavonoid contents were 83.85 ± 0.89 mg gallic acid equivalents/g and 78.91 ± 0.41 mg rutin equivalents/g, respectively. The extract actively scavenged DPPH and ABTS radicals (540.01 and 639.11 mg Trolox equivalents (TE)/g), possessed high potential to reduce copper and iron ions (660.32 and 869.22 mg TE/g, respectively), and demonstrated high metal chelating capacity (15.57 Ethylenediaminetetraacetic acid equivalents/g). It exhibited prominent anti-lipase (18.32 mg orlistat equivalents/g) and anti-tyrosinase (71.90 mg kojic acid equivalents/g) activity. The extract inhibited α-glucoside (1.35 mmol acarbose equivalents/g) and acetylcholinesterase (2.56 mg galanthamin equivalents/g), and had moderate effects on α-amylase, elastase, collagenase and hyaluronidase. Balkan heath could be recommended for raw material production with antioxidant and enzyme inhibitory properties. Full article
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