Special Issue "Progress in Neurophotonics and Its Future Perspectives"

A special issue of Photonics (ISSN 2304-6732). This special issue belongs to the section "Biophotonics and Biomedical Optics".

Deadline for manuscript submissions: 30 March 2023 | Viewed by 718

Special Issue Editors

Department of Medical Engineering, University of South Florida, Tampa, FL 33620, USA
Interests: biomedical optics/biophotonics; diffuse optical tomography; photoacoustic tomography; fluorescence molecular tomography; thermoacoustic tomography; image-guided interventions of cancers and neurodisorders
Special Issues, Collections and Topics in MDPI journals
School of Optoelectric Engineering, Chongqing University of Posts and Telecommunications, Chongqing 400065, China
Interests: medical optical imaging; photoacoustic tomography; molecular imaging; functional monitoring; image reconstruction; imaging system
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305-5723, USA
Interests: diffuse optical tomography; optical functional neuroimaging; brain stimulation; delirium; depression

Special Issue Information

Dear Colleagues,

Neurophotonics is becoming one of the most important and rapidly evolving subfields in photonics, in which optical/photonic methods/technologies are applied to study the brain at molecular, cellular and tissue levels. Structure­­–function and brain-behavior relationships can now be visualized, often noninvasively, using optical technologies at microscopic, mesoscopic and macroscopic scales across all species. Our understanding in important fields of neuroscience such as electrical excitability, neuroglial partnership, neurovascular signaling, metabolic activity and hemodynamics in healthy and diseased conditions has also significantly improved due to the development of novel optical technologies.

The purpose of this Special Issue is to provide a vehicle for communicating important advancements in the use of optical methods/technologies to study brain function, organization and structure microscopically, mesoscopically or macroscopically. This Special Issue also welcomes works that explicitly address these questions in animal models or clinical populations. Some representative, but not exhaustive, examples include the development and applications of:

  • Advanced optical techniques;
  • Imaging and manipulation of neural circuitry;
  • Methods to investigate cellular energetics;
  • Methods to investigate neuroglial and vascular physiology;
  • Microscopy and super-resolution optical microscopy;
  • Fluorescence imaging;
  • Diffuse optical tomography;
  • Near-infrared spectroscopy;
  • Diffuse correlation spectroscopy/tomography;
  • Fluorescence molecular tomography;
  • Molecular imaging and nanotheranostics;
  • Multimodal optical imaging;
  • Noninvasive methods of measuring and imaging brain function and physiology;
  • Optical clearing methods;
  • Optogenetics and other optical methods of manipulating cellular behavior;
  • Photoacoustic tomography and microscopy;
  • Optoacoustic neuromodulation;
  • Photodynamic therapy;
  • Photoimmunotherapy;
  • Photobiomodulation;
  • Synthetic and genetically encoded optical reporters and actuators;
  • Theoretical and computational optical methods;
  • Translational and clinical applications.

We invite you to contribute an original research article or a review to this Special Issue of Photonics, entitled “Progress in Neurophotonics and Its Future Perspectives”.

Prof. Dr. Huabei Jiang
Dr. Dan Wu
Dr. Shixie Jiang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Photonics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Effects of Pulsed Red and Near-Infrared Light on Neuroblastoma Cells—Pilot Study on Frequency and Duty Cycle
Photonics 2023, 10(3), 315; https://doi.org/10.3390/photonics10030315 - 15 Mar 2023
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Transcranial photobiomodulation (tPBM) is an innovative intervention for a wide range of neurological and psychological conditions. tPBM therapy can enhance the metabolic capacity of neurons and bring about a variety of beneficial changes. This study mainly investigated the photobiological effects of pulsed red [...] Read more.
Transcranial photobiomodulation (tPBM) is an innovative intervention for a wide range of neurological and psychological conditions. tPBM therapy can enhance the metabolic capacity of neurons and bring about a variety of beneficial changes. This study mainly investigated the photobiological effects of pulsed red and near-infrared (NIR) light on neuron-like neuroblastoma SH-SY5Y cells by in vitro experiments. We covered the irradiation parameters, including wavelength (660, 850 nm), power density (5, 10, 20, 50, 100 mW/cm2), frequency (40, 100, 1000 Hz), and duty cycle (10%, 50%, 90%), finding that pulsed light generated a distinct effect compared with continuous-wave light on the cellular responses. Cell viability, mitochondrial membrane potential (MMP), adenosine triphosphate (ATP), and reactive oxygen species (ROS) showed significant increase after irradiation of the adequate fluence amount (4.8–9.6 J/cm2), and the enhancement was more notable under 40 Hz pulsed lighting. Under pulsed lighting with an average power density of 10 mW/cm2, cells that received irradiation of higher peak power density up to 100 mW/cm2 with a 10% duty cycle showed slightly higher metabolic responses. In addition, it was found that under same total fluence, short-term irradiation with high power density was more effective than long-term irradiation with low power density, which indicated the existence of a threshold to achieve effectiveness. Full article
(This article belongs to the Special Issue Progress in Neurophotonics and Its Future Perspectives)
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