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Photonics
Special Issues
Advanced Techniques in Biomedical Optical Imaging
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Advanced Techniques in Biomedical Optical Imaging

A special issue of Photonics (ISSN 2304-6732). This special issue belongs to the section "Biophotonics and Biomedical Optics".

Deadline for manuscript submissions: closed (30 October 2023) | Viewed by 9989

Special Issue Editors

Dr. Haigang Ma

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Guest Editor
Associate Professor, School of Electronic and Optical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China
Interests: photoacoustic imaging technology; photoelectric detection and image engineering; multi-dimensional ultrasonic detection and imaging
Special Issues, Collections and Topics in MDPI journals
Dr. Yujiao Shi

E-Mail Website
Guest Editor
Associate Professor, College of Biophotonics, Institute of Life Science, South China Normal University, Guangzhou, China
Interests: biomedical imaging; photoacoustic imaging
Special Issues, Collections and Topics in MDPI journals
Dr. Yue Zhao

E-Mail Website
Guest Editor
Associate Professor, School of Physics and Optoelectronic Engineering, Shandong University of Technology, Zibo 255049, China
Interests: biological and medical physics; biophotonics; biomedical optics; photoacoustic imaging; X-ray-induced acoustic computed tomography
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biomedical optical imaging is a rapidly developing field with numerous exciting applications in clinical diagnosis and biological research, which is due to the superior spatial resolution, rich imaging contrast, and non-ionizing properties of light radiation. Important new advancements of optical imaging equipment and technology can contribute to key breakthroughs and discoveries in disease diagnosis and biological exploration, such as photoacoustic imaging, optical coherence tomography, diffuse optical tomography, fluorescence spectroscopy, Raman spectroscopy, confocal and multiphoton microscopy, super-resolution microscopy, and many others. Some technologies have been translated to biomedical applications, and some are yet to be applied. Joint efforts from both the optical and biomedical communities are still needed to fully discover the potential of these optical modalities and promote them as routine laboratory and/or clinical apparatuses.

This Special Issue invites manuscripts that introduce recent advances in “Advanced Techniques in Biomedical Optical Imaging”. All theoretical, numerical, and experimental papers are accepted for submission. Original research papers and review articles are both welcome. Topics include, but are not limited to, the following:

  • Optical microscopy;
  • Photoacoustic imaging and spectroscopy;
  • Optical coherent tomography;
  • Diffuse optical tomography;
  • Spectroscopic and imaging techniques;
  • Multimodality and multiscale approaches;
  • Machine learning and image processing;
  • Basic research and translational research.

Dr. Haigang Ma
Dr. Yujiao Shi
Dr. Yue Zhao
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Photonics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • optical microscopy
  • photoacoustic imaging and spectroscopy
  • optical coherent tomography
  • diffuse optical tomography
  • spectroscopic and imaging techniques
  • multimodality and multiscale approaches
  • machine learning and image processing
  • basic research and translational research

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (4 papers)

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Research

11 pages, 5670 KiB  
Article
Mechanical Assessment in Atherosclerosis Based on Photoacoustic Viscoelasticity Imaging
by Xingchao Zhang, Xiaohan Shi, Hui Wu, Caixun Bai, Junshan Xiu and Yue Zhao
Photonics 2024, 11(5), 471; https://doi.org/10.3390/photonics11050471 - 17 May 2024
Cited by 1 | Viewed by 1450
Abstract
Early identification of vulnerable plaques is a major challenge in diagnosis and assessment of atherosclerosis. In atherosclerotic plaque development, the proportion change in components caused plaque mechanical property change and induced plaque rupture. In this paper, a photoacoustic viscoelasticity imaging (PAVEI) technique was [...] Read more.
Early identification of vulnerable plaques is a major challenge in diagnosis and assessment of atherosclerosis. In atherosclerotic plaque development, the proportion change in components caused plaque mechanical property change and induced plaque rupture. In this paper, a photoacoustic viscoelasticity imaging (PAVEI) technique was proposed to measure the viscosity–elasticity ratio of atherosclerotic plaque and evaluated for the potential in characterizing vulnerable plaques. Apolipoprotein E-knockout mice fed with a high-fat/high-cholesterol diet were chosen as the atherosclerotic model. Plaque component phantoms were examined to demonstrate the high efficiency of PAVEI in detecting the proportion change in components compared to single elasticity or viscosity detection. Finally, atherosclerotic plaques from mice aortas at different stages were imaged by PAVEI, which provided an insight into the compositional and functional characterization of vulnerability plaques and suggested its potential applications in the identification of high-risk plaques. Full article
(This article belongs to the Special Issue Advanced Techniques in Biomedical Optical Imaging)
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22 pages, 10451 KiB  
Article
Investigation of an Improved Angular Spectrum Method Based on Holography
by Ting Wu, Yuling Yang, Hao Wang, Hao Chen, Hao Zhu, Jisheng Yu and Xiuxin Wang
Photonics 2024, 11(1), 16; https://doi.org/10.3390/photonics11010016 - 25 Dec 2023
Cited by 2 | Viewed by 2477
Abstract
Digital holography (DH) is a novel, real-time, non-destructive, and quantitative phase-contrast imaging method that is particularly suitable for label-free live biological cell imaging and real-time dynamic monitoring. It is currently a research hotspot in the interdisciplinary field of optics and biomedical sciences, both [...] Read more.
Digital holography (DH) is a novel, real-time, non-destructive, and quantitative phase-contrast imaging method that is particularly suitable for label-free live biological cell imaging and real-time dynamic monitoring. It is currently a research hotspot in the interdisciplinary field of optics and biomedical sciences, both domestically and internationally. This article proposes an improved angle spectrum algorithm based on holographic technology, which reconstructs a cellular hologram based on phase information. Optical images and chromosome cell images, reconstructed using holographic technology at different diffraction distances under the improved angle spectrum algorithm, were analyzed and compared. The optimal diffraction distance for reconstructing chromosome cell images was selected, and chromosome cell images reproduced using traditional angle spectrum algorithms, angle spectrum algorithms combined with GS, and improved angle spectrum algorithms were compared. Comparative experiments with the different models show that the proposed algorithm is superior to traditional angle spectrum algorithms in reconstructing cell images based on phase information. Furthermore, experiments have shown that images reconstructed using the improved algorithm can resolve high signal-to-noise ratio information. This algorithmic improvement provides new applications for cellular detection in clinical diagnostics and is more suitable for cell phase reconstruction in practical applications. Full article
(This article belongs to the Special Issue Advanced Techniques in Biomedical Optical Imaging)
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14 pages, 4302 KiB  
Article
A Generic and Effective System Dispersion Compensation Method: Development and Validation in Visible-Light OCT
by Jiarui Wang, Chao Xu, Shaodi Zhu, Defu Chen, Haixia Qiu, Alexander K. N. Lam, Christopher K. S. Leung and Wu Yuan
Photonics 2023, 10(8), 892; https://doi.org/10.3390/photonics10080892 - 2 Aug 2023
Cited by 11 | Viewed by 2710
Abstract
Compared with optical coherence tomography (OCT) in the near-infrared domain, the visible-light OCT (vis-OCT) system affords a higher axial resolution for discerning subtle pathological changes associated with early diseases. However, the significant material dispersion at the visible-light range leads to a severe problem [...] Read more.
Compared with optical coherence tomography (OCT) in the near-infrared domain, the visible-light OCT (vis-OCT) system affords a higher axial resolution for discerning subtle pathological changes associated with early diseases. However, the significant material dispersion at the visible-light range leads to a severe problem for dispersion management in vis-OCT systems, which results in a compromised axial resolution. While dispersion compensators (such as prism pairs) are commonly used, a digital method is still highly desirable and has been widely used to compensate for the residual dispersion imbalance between the reference and sample arms in an OCT system. In this paper, we develop a generic approach to effectively compensate for the system dispersion, especially the higher-order dispersion in the vis-OCT system, by using a single arbitrary measurement of the mirror-reflection (SAMMR) method and its resulting phase information. Compared with the previous methods, including the method based on the Taylor series iterative fitting and differential method, the proposed method does not need to extract the dispersion coefficients or use the metric functions and affords a better performance for axial resolution and the signal-to-noise ratio in vis-OCT systems. Its effectiveness is further validated in an OCT system operating in the near-infrared domain. Full article
(This article belongs to the Special Issue Advanced Techniques in Biomedical Optical Imaging)
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9 pages, 2483 KiB  
Communication
Non-Contact Real-Time Measurement of Refractive Index of Flowing Liquid Based on Optical Coherence Tomography
by Hongbo Fu, Weijian Gao, Zixin Lin, Zhemin Zeng, Wen Shi and Jian Zhang
Photonics 2023, 10(7), 841; https://doi.org/10.3390/photonics10070841 - 20 Jul 2023
Cited by 1 | Viewed by 2385
Abstract
The refractive index (RI) is one of the liquid’s most important physical parameters of liquid. The change of RI usually indicates the change of liquid properties, and this relation leads to broad application. This paper proposes a method based on optical coherence tomography [...] Read more.
The refractive index (RI) is one of the liquid’s most important physical parameters of liquid. The change of RI usually indicates the change of liquid properties, and this relation leads to broad application. This paper proposes a method based on optical coherence tomography (OCT) to measure the RI of liquid in real time. A series of targeted image-processing techniques play a vital role in this method. Benefiting from the advantages of OCT, this method does not require the operators to come into direct contact with liquids. Moreover, the principles and techniques adopted in this method imply that the measuring range of RI of unknown liquids is unlimited. The effectiveness of this method is validated by the experiment measuring the RI of sucrose liquids with gradient concentration. Another experiment thoroughly verifies this method’s feasibility in predicting sucrose concentration based on real-time measured RI. This simple and easy proposed method indicates an immense potential application prospect in the industry and scientific research. Full article
(This article belongs to the Special Issue Advanced Techniques in Biomedical Optical Imaging)
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