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Pharmaceutics
Special Issues
Transmucosal Absorption Enhancers in the Drug Delivery Field
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Special Issue "Transmucosal Absorption Enhancers in the Drug Delivery Field"

A special issue of Pharmaceutics (ISSN 1999-4923).

Deadline for manuscript submissions: closed (15 January 2019) | Viewed by 132469

Printed Edition Available!
A printed edition of this Special Issue is available here.

Special Issue Editors

Dr. Luca Casettari

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Guest Editor
Department of Biomolecular Sciences, University of Urbino "Carlo Bo", 61029 Urbino, Italy
Interests: drug delivery systems; biopolymers; cosmetics; surfactants
Special Issues, Collections and Topics in MDPI journals
Dr. Sam Maher

E-Mail
Guest Editor
School of Pharmacy, Royal College of Surgeons in Ireland, St. Stephen’s Green, Dublin 2, Ireland
Interests: lipid based formulations; surfactants; oral formulation of advanced drug delivery systems; toxicokinetics; permeation enhancers
Prof. Lisbeth Illum

E-Mail
Guest Editor
Oakleigh, 80 Mount Durand, St. Peter Port, Guernsey GY1 1DX, Channel Islands, UK
Interests: transmucosal drug delivery systems; nasal drug delivery; transmucosal absorption enhancers

Special Issue Information

Dear Colleagues,

Development of strategies to assist the movement of poorly permeable molecules across biological barriers has long been the goal of drug delivery science. In the last three decades, there has been an exponential increase in advanced drug delivery systems that aim to address this issue. However, most proprietary delivery technologies that have progressed to clinical development are based on permeation enhancers (PEs) that have a history of safe use in man. This Special Issue entitled “Transmucosal Absorption Enhancers in the Drug Delivery Field” aims to present the current state-of-the-art in the application of PEs to improve drug absorption. Emphasis is placed on identification of novel permeation enhancers, mechanisms of barrier alteration, physicochemical properties of PEs that contribute to optimal enhancement action, new delivery models to assess PEs, studies assessing safety of PEs, approaches to assist translation of PEs into effective oral dosage forms and combining PEs with other delivery strategies (e.g., nanoparticles).

We invite research scientists from the pharmaceutical/food industry or academia to submit original research articles, review articles or commentaries. This Special Issue will provide researchers with an up to date resource on how PEs are used to address sub-optimal permeability.

Prof. Luca Casettari
Dr. Sam Maher
Prof. Lisbeth Illum
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Transmucosal absorption enhancers
  • Barriers to mucosal absorption
  • Mechanisms of drug absorption enhancement
  • Permeability enhancement of small molecules and biomolecules
  • Advanced transmucosal formulations for drug delivery

Published Papers (20 papers)

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10 pages, 244 KiB  
Editorial
Transmucosal Absorption Enhancers in the Drug Delivery Field
Pharmaceutics 2019, 11(7), 339; https://doi.org/10.3390/pharmaceutics11070339 - 15 Jul 2019
33 pages, 5435 KiB  
Review
Penetration Enhancers in Ocular Drug Delivery
Pharmaceutics 2019, 11(7), 321; https://doi.org/10.3390/pharmaceutics11070321 - 09 Jul 2019
9 pages, 1154 KiB  
Article
Delivery of Nanoparticles across the Intestinal Epithelium via the Transferrin Transport Pathway
Pharmaceutics 2019, 11(7), 298; https://doi.org/10.3390/pharmaceutics11070298 - 26 Jun 2019
17 pages, 2674 KiB  
Article
Nasal Administration and Plasma Pharmacokinetics of Parathyroid Hormone Peptide PTH 1-34 for the Treatment of Osteoporosis
Pharmaceutics 2019, 11(6), 265; https://doi.org/10.3390/pharmaceutics11060265 - 07 Jun 2019
16 pages, 3312 KiB  
Article
Mechanistic Studies on the Absorption-Enhancing Effects of Gemini Surfactant on the Intestinal Absorption of Poorly Absorbed Hydrophilic Drugs in Rats
Pharmaceutics 2019, 11(4), 170; https://doi.org/10.3390/pharmaceutics11040170 - 07 Apr 2019
20 pages, 1450 KiB  
Review
Strategies to Enhance Drug Absorption via Nasal and Pulmonary Routes
Pharmaceutics 2019, 11(3), 113; https://doi.org/10.3390/pharmaceutics11030113 - 11 Mar 2019
19 pages, 2932 KiB  
Article
Chitosan-Coated Nanoparticles: Effect of Chitosan Molecular Weight on Nasal Transmucosal Delivery
Pharmaceutics 2019, 11(2), 86; https://doi.org/10.3390/pharmaceutics11020086 - 18 Feb 2019
21 pages, 1614 KiB  
Review
Intestinal Permeation Enhancers for Oral Delivery of Macromolecules: A Comparison between Salcaprozate Sodium (SNAC) and Sodium Caprate (C10)
Pharmaceutics 2019, 11(2), 78; https://doi.org/10.3390/pharmaceutics11020078 - 13 Feb 2019
21 pages, 6117 KiB  
Article
Dual Action of the PN159/KLAL/MAP Peptide: Increase of Drug Penetration across Caco-2 Intestinal Barrier Model by Modulation of Tight Junctions and Plasma Membrane Permeability
Pharmaceutics 2019, 11(2), 73; https://doi.org/10.3390/pharmaceutics11020073 - 10 Feb 2019
17 pages, 4113 KiB  
Article
Chitosan Plus Compound 48/80: Formulation and Preliminary Evaluation as a Hepatitis B Vaccine Adjuvant
Pharmaceutics 2019, 11(2), 72; https://doi.org/10.3390/pharmaceutics11020072 - 09 Feb 2019
23 pages, 983 KiB  
Review
Application of Permeation Enhancers in Oral Delivery of Macromolecules: An Update
Pharmaceutics 2019, 11(1), 41; https://doi.org/10.3390/pharmaceutics11010041 - 19 Jan 2019
17 pages, 4297 KiB  
Article
Intestinal Drug Absorption Enhancement by Aloe vera Gel and Whole Leaf Extract: In Vitro Investigations into the Mechanisms of Action
Pharmaceutics 2019, 11(1), 36; https://doi.org/10.3390/pharmaceutics11010036 - 18 Jan 2019
46 pages, 2240 KiB  
Review
Drug Bioavailability Enhancing Agents of Natural Origin (Bioenhancers) that Modulate Drug Membrane Permeation and Pre-Systemic Metabolism
Pharmaceutics 2019, 11(1), 33; https://doi.org/10.3390/pharmaceutics11010033 - 16 Jan 2019
16 pages, 4527 KiB  
Article
Enhanced Delivery of Imatinib into Vaginal Mucosa via a New Positively Charged Nanocrystal-Loaded in Situ Hydrogel Formulation for Treatment of Cervical Cancer
Pharmaceutics 2019, 11(1), 15; https://doi.org/10.3390/pharmaceutics11010015 - 04 Jan 2019
Correction
18 pages, 3459 KiB  
Article
N-(2-Hydroxy)-propyl-3-trimethylammonium, O-Mysristoyl Chitosan Enhances the Solubility and Intestinal Permeability of Anticancer Curcumin
Pharmaceutics 2018, 10(4), 245; https://doi.org/10.3390/pharmaceutics10040245 - 20 Nov 2018
20 pages, 3536 KiB  
Article
A Tailored Thermosensitive PLGA-PEG-PLGA/Emulsomes Composite for Enhanced Oxcarbazepine Brain Delivery via the Nasal Route
Pharmaceutics 2018, 10(4), 217; https://doi.org/10.3390/pharmaceutics10040217 - 05 Nov 2018
15 pages, 3726 KiB  
Article
The Role of Combined Penetration Enhancers in Nasal Microspheres on In Vivo Drug Bioavailability
Pharmaceutics 2018, 10(4), 206; https://doi.org/10.3390/pharmaceutics10040206 - 26 Oct 2018
21 pages, 4610 KiB  
Article
Hydrophobic Amino Acid Tryptophan Shows Promise as a Potential Absorption Enhancer for Oral Delivery of Biopharmaceuticals
Pharmaceutics 2018, 10(4), 182; https://doi.org/10.3390/pharmaceutics10040182 - 10 Oct 2018
17 pages, 6770 KiB  
Article
Probing the Action of Permeation Enhancers Sodium Cholate and N-dodecyl-β-D-maltoside in a Porcine Jejunal Mucosal Explant System
Pharmaceutics 2018, 10(4), 172; https://doi.org/10.3390/pharmaceutics10040172 - 02 Oct 2018
18 pages, 2305 KiB  
Article
Synthesis, Structure–Activity Relationships and In Vitro Toxicity Profile of Lactose-Based Fatty Acid Monoesters as Possible Drug Permeability Enhancers
Pharmaceutics 2018, 10(3), 81; https://doi.org/10.3390/pharmaceutics10030081 - 03 Jul 2018
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