Special Issue "Transmucosal Absorption Enhancers in the Drug Delivery Field"

A special issue of Pharmaceutics (ISSN 1999-4923).

Deadline for manuscript submissions: closed (15 January 2019)

Special Issue Editors

Guest Editor
Prof. Luca Casettari

Department of Biomolecular Sciences, University of Urbino Carlo Bo, Piazza del Rinascimento 6, Urbino, 61029 Urbino, Italy
Website | E-Mail
Interests: drug delivery systems; biopolymers; cosmetics; surfactants
Guest Editor
Dr. Sam Maher

School of Pharmacy, Royal College of Surgeons in Ireland, St. Stephen’s Green, Dublin 2, Ireland
Interests: lipid based formulations; surfactants; oral formulation of advanced drug delivery systems; toxicokinetics; permeation enhancers
Guest Editor
Prof. Lisbeth Illum

Oakleigh, 80 Mount Durand, St. Peter Port, Guernsey GY1 1DX, Channel Islands, UK
Interests: transmucosal drug delivery systems; nasal drug delivery; transmucosal absorption enhancers

Special Issue Information

Dear Colleagues,

Development of strategies to assist the movement of poorly permeable molecules across biological barriers has long been the goal of drug delivery science. In the last three decades, there has been an exponential increase in advanced drug delivery systems that aim to address this issue. However, most proprietary delivery technologies that have progressed to clinical development are based on permeation enhancers (PEs) that have a history of safe use in man. This Special Issue entitled “Transmucosal Absorption Enhancers in the Drug Delivery Field” aims to present the current state-of-the-art in the application of PEs to improve drug absorption. Emphasis is placed on identification of novel permeation enhancers, mechanisms of barrier alteration, physicochemical properties of PEs that contribute to optimal enhancement action, new delivery models to assess PEs, studies assessing safety of PEs, approaches to assist translation of PEs into effective oral dosage forms and combining PEs with other delivery strategies (e.g., nanoparticles).

We invite research scientists from the pharmaceutical/food industry or academia to submit original research articles, review articles or commentaries. This Special Issue will provide researchers with an up to date resource on how PEs are used to address sub-optimal permeability.

Prof. Luca Casettari
Dr. Sam Maher
Prof. Lisbeth Illum
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Transmucosal absorption enhancers
  • Barriers to mucosal absorption
  • Mechanisms of drug absorption enhancement
  • Permeability enhancement of small molecules and biomolecules
  • Advanced transmucosal formulations for drug delivery

Published Papers (14 papers)

View options order results:
result details:
Displaying articles 1-14
Export citation of selected articles as:
Open AccessArticle
Chitosan-Coated Nanoparticles: Effect of Chitosan Molecular Weight on Nasal Transmucosal Delivery
Pharmaceutics 2019, 11(2), 86; https://doi.org/10.3390/pharmaceutics11020086 (registering DOI)
Received: 1 February 2019 / Revised: 14 February 2019 / Accepted: 15 February 2019 / Published: 18 February 2019
PDF Full-text (1414 KB)
Open AccessReview
Intestinal Permeation Enhancers for Oral Delivery of Macromolecules: A Comparison between Salcaprozate Sodium (SNAC) and Sodium Caprate (C10)
Pharmaceutics 2019, 11(2), 78; https://doi.org/10.3390/pharmaceutics11020078
Received: 21 January 2019 / Revised: 8 February 2019 / Accepted: 11 February 2019 / Published: 13 February 2019
PDF Full-text (1614 KB) | HTML Full-textXML Full-text
Open AccessArticle
Dual Action of the PN159/KLAL/MAP Peptide: Increase of Drug Penetration across Caco-2 Intestinal Barrier Model by Modulation of Tight Junctions and Plasma Membrane Permeability
Pharmaceutics 2019, 11(2), 73; https://doi.org/10.3390/pharmaceutics11020073
Received: 10 December 2018 / Revised: 26 January 2019 / Accepted: 5 February 2019 / Published: 10 February 2019
PDF Full-text (1577 KB)
Open AccessArticle
Chitosan Plus Compound 48/80: Formulation and Preliminary Evaluation as a Hepatitis B Vaccine Adjuvant
Pharmaceutics 2019, 11(2), 72; https://doi.org/10.3390/pharmaceutics11020072
Received: 22 December 2018 / Revised: 22 January 2019 / Accepted: 4 February 2019 / Published: 9 February 2019
PDF Full-text (1979 KB)
Open AccessReview
Application of Permeation Enhancers in Oral Delivery of Macromolecules: An Update
Pharmaceutics 2019, 11(1), 41; https://doi.org/10.3390/pharmaceutics11010041
Received: 21 December 2018 / Revised: 11 January 2019 / Accepted: 14 January 2019 / Published: 19 January 2019
PDF Full-text (983 KB) | HTML Full-textXML Full-text
Open AccessArticle
Intestinal Drug Absorption Enhancement by Aloe vera Gel and Whole Leaf Extract: In Vitro Investigations into the Mechanisms of Action
Pharmaceutics 2019, 11(1), 36; https://doi.org/10.3390/pharmaceutics11010036
Received: 27 November 2018 / Revised: 12 December 2018 / Accepted: 13 December 2018 / Published: 18 January 2019
PDF Full-text (4297 KB) | HTML Full-textXML Full-text
Open AccessReview
Drug Bioavailability Enhancing Agents of Natural Origin (Bioenhancers) that Modulate Drug Membrane Permeation and Pre-Systemic Metabolism
Pharmaceutics 2019, 11(1), 33; https://doi.org/10.3390/pharmaceutics11010033
Received: 11 December 2018 / Revised: 23 December 2018 / Accepted: 24 December 2018 / Published: 16 January 2019
PDF Full-text (2240 KB) | HTML Full-textXML Full-text
Open AccessArticle
Enhanced Delivery of Imatinib into Vaginal Mucosa via a New Positively Charged Nanocrystal-Loaded in Situ Hydrogel Formulation for Treatment of Cervical Cancer
Pharmaceutics 2019, 11(1), 15; https://doi.org/10.3390/pharmaceutics11010015
Received: 14 November 2018 / Revised: 7 December 2018 / Accepted: 9 December 2018 / Published: 4 January 2019
PDF Full-text (5759 KB) | HTML Full-textXML Full-text | Supplementary Files
Open AccessArticle
N-(2-Hydroxy)-propyl-3-trimethylammonium, O-Mysristoyl Chitosan Enhances the Solubility and Intestinal Permeability of Anticancer Curcumin
Pharmaceutics 2018, 10(4), 245; https://doi.org/10.3390/pharmaceutics10040245
Received: 30 September 2018 / Revised: 15 November 2018 / Accepted: 16 November 2018 / Published: 20 November 2018
PDF Full-text (3459 KB) | HTML Full-textXML Full-text
Open AccessArticle
A Tailored Thermosensitive PLGA-PEG-PLGA/Emulsomes Composite for Enhanced Oxcarbazepine Brain Delivery via the Nasal Route
Pharmaceutics 2018, 10(4), 217; https://doi.org/10.3390/pharmaceutics10040217
Received: 10 October 2018 / Revised: 28 October 2018 / Accepted: 1 November 2018 / Published: 5 November 2018
PDF Full-text (3536 KB) | HTML Full-textXML Full-text | Supplementary Files
Open AccessArticle
The Role of Combined Penetration Enhancers in Nasal Microspheres on In Vivo Drug Bioavailability
Pharmaceutics 2018, 10(4), 206; https://doi.org/10.3390/pharmaceutics10040206
Received: 21 September 2018 / Revised: 22 October 2018 / Accepted: 23 October 2018 / Published: 26 October 2018
PDF Full-text (3726 KB) | HTML Full-textXML Full-text
Open AccessArticle
Hydrophobic Amino Acid Tryptophan Shows Promise as a Potential Absorption Enhancer for Oral Delivery of Biopharmaceuticals
Pharmaceutics 2018, 10(4), 182; https://doi.org/10.3390/pharmaceutics10040182
Received: 24 August 2018 / Revised: 18 September 2018 / Accepted: 8 October 2018 / Published: 10 October 2018
PDF Full-text (4610 KB) | HTML Full-textXML Full-text
Open AccessArticle
Probing the Action of Permeation Enhancers Sodium Cholate and N-dodecyl-β-D-maltoside in a Porcine Jejunal Mucosal Explant System
Pharmaceutics 2018, 10(4), 172; https://doi.org/10.3390/pharmaceutics10040172
Received: 28 August 2018 / Revised: 27 September 2018 / Accepted: 28 September 2018 / Published: 2 October 2018
PDF Full-text (6770 KB) | HTML Full-textXML Full-text
Open AccessArticle
Synthesis, Structure–Activity Relationships and In Vitro Toxicity Profile of Lactose-Based Fatty Acid Monoesters as Possible Drug Permeability Enhancers
Pharmaceutics 2018, 10(3), 81; https://doi.org/10.3390/pharmaceutics10030081
Received: 30 May 2018 / Revised: 26 June 2018 / Accepted: 2 July 2018 / Published: 3 July 2018
Cited by 1PDF Full-text (2305 KB) | HTML Full-textXML Full-text
Pharmaceutics EISSN 1999-4923 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top