Advances in Pharmaceutical Solid Forms
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".
Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 23586
Special Issue Editor
Interests: solid state chemistry; co-crystal science; active pharmaceutical ingredient and excipient stability; polymorphs screening; nanomedicine; drug formulation; physical chemistry of pharmaceutical ingredients; pharmacokinetics; in vitro dissolution studies; nanocrystals; nanoemulsions
Special Issue Information
Dear Colleagues,
Solubility enhancement of poorly water-soluble drugs is a major challenge in the pharmaceutical field since 80% of the marketed drugs are formulated in solid state and more than 70% of the drugs in development exhibit low solubility (BCS class II and IV). Nevertheless, solid dosage forms are widely favored, mainly due to stability issues of the active ingredients.
A broad and comprehensive study of various solid forms of the pharmaceutical matter is needed to enhance their clinical translation with optimized success. Indeed, the most suitable solid forms have to be taken into consideration regarding their stability and bioavailability.
Many matter modification processes in the solid state, such as salts, solid solutions, scalemic mixtures, amorphous, polymorphs, solvatomorphs, nanocrystals, guest-host assemblies, nanocarriers, and cocrystals formation, have been adapted to challenge and improve both drug substance loading capacity and bioavailability. Each system presents its own advantages and drawbacks, depending on the administration route, the therapeutic target, the release rate of the drug, the final product manufacturing, and the cost of production; the objective behind this survey is to enhance the benefice/risk ratio of innovative formulation for adaptative treatments.
Reviews and original articles dealing with the modulation of pharmaceutical solid dosage forms (with organic or inorganic active ingredients) for formulation, storage, and therapeutic effect enhancement are encouraged for publication in this Special Issue of Pharmaceutics.
Prof. Dr. Yohann Corvis
Guest Editor
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Keywords
- salt formation
- solvate/hydrate formation
- size reduction
- polymorphism
- amorphisation
- solid solutions
- solid suspensions
- enantiomeric vs. racemic drugs
- active ingredient: excipient interactions
- active ingredient: active ingredient interactions
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