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Nanosystems as Vehicles for the Delivery of Antimicrobial Peptides (AMPs)

Department of Organic and Inorganic Chemistry, and Research Institute in Chemistry ”Andrés M. Del Río” (IQAR), University of Alcalá, 28805 Madrid, Spain
Institute Ramón y Cajal for Health Research (IRYCIS), 28034 Madrid, Spain
Networking Research Centre on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 28029 Madrid, Spain
Authors to whom correspondence should be addressed.
Pharmaceutics 2019, 11(9), 448;
Received: 14 June 2019 / Revised: 24 August 2019 / Accepted: 27 August 2019 / Published: 2 September 2019
(This article belongs to the Special Issue Breakthroughs in Antimicrobial Peptides)
Recently, antimicrobial peptides (AMPs), also called host defence peptides (HDPs), are attracting great interest, as they are a highly viable alternative in the search of new approaches to the resistance presented by bacteria against antibiotics in infectious diseases. However, due to their nature, they present a series of disadvantages such as low bioavailability, easy degradability by proteases, or low solubility, among others, which limits their use as antimicrobial agents. For all these reasons, the use of vehicles for the delivery of AMPs, such as polymers, nanoparticles, micelles, carbon nanotubes, dendrimers, and other types of systems, allows the use of AMPs as a real alternative to treatment with antibiotics. View Full-Text
Keywords: AMPs; HDPs; carriers; delivery; antimicrobial agents AMPs; HDPs; carriers; delivery; antimicrobial agents
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MDPI and ACS Style

Martin-Serrano, Á.; Gómez, R.; Ortega, P.; de la Mata, F.J. Nanosystems as Vehicles for the Delivery of Antimicrobial Peptides (AMPs). Pharmaceutics 2019, 11, 448.

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