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Biofilms: Novel Strategies Based on Antimicrobial Peptides

Department of Biology, University of Naples Federico II, Via Cinthia, 80126 Naples, Italy
Department of Pharmacy, University of Naples Federico II, Via Mezzocannone 16, 80134 Naples, Italy
Department of Agricultural Sciences, University of Naples Federico II, Via Università 100, 80055 Portici, Italy
Author to whom correspondence should be addressed.
Pharmaceutics 2019, 11(7), 322;
Received: 21 May 2019 / Revised: 24 June 2019 / Accepted: 6 July 2019 / Published: 10 July 2019
(This article belongs to the Special Issue Breakthroughs in Antimicrobial Peptides)
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The problem of drug resistance is very worrying and ever increasing. Resistance is due not only to the reckless use of antibiotics but also to the fact that pathogens are able to adapt to different conditions and develop self-defense mechanisms such as living in biofilms; altogether these issues make the search for alternative drugs a real challenge. Antimicrobial peptides appear as promising alternatives but they have disadvantages that do not make them easily applicable in the medical field; thus many researches look for solutions to overcome the disadvantages and ensure that the advantages can be exploited. This review describes the biofilm characteristics and identifies the key features that antimicrobial peptides should have. Recalcitrant bacterial infections caused by the most obstinate bacterial species should be treated with a strategy to combine conventional peptides functionalized with nano-tools. This approach could effectively disrupt high density infections caused by biofilms. Moreover, the importance of using in vivo non mammalian models for biofilm studies is described. In particular, here we analyze the use of amphibians as a model to substitute the rodent model. View Full-Text
Keywords: anti-biofilms peptides; biofilm in vitro; biofilm in vivo; nanotechnology anti-biofilms peptides; biofilm in vitro; biofilm in vivo; nanotechnology

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Galdiero, E.; Lombardi, L.; Falanga, A.; Libralato, G.; Guida, M.; Carotenuto, R. Biofilms: Novel Strategies Based on Antimicrobial Peptides. Pharmaceutics 2019, 11, 322.

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