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A New Hope: Self-Assembling Peptides with Antimicrobial Activity

Department of Pharmacy, University of Naples Federico II, Via Mezzocannone 16, 80134 Naples, Italy
Department of Agricultural Science, University of Naples Federico II, Via Mezzocannone 16, 80134 Naples, Italy
Author to whom correspondence should be addressed.
Pharmaceutics 2019, 11(4), 166;
Received: 6 March 2019 / Revised: 22 March 2019 / Accepted: 29 March 2019 / Published: 4 April 2019
(This article belongs to the Special Issue Breakthroughs in Antimicrobial Peptides)
PDF [1094 KB, uploaded 4 April 2019]


Peptide drugs hold great promise for the treatment of infectious diseases thanks to their novel mechanisms of action, low toxicity, high specificity, and ease of synthesis and modification. Naturally developing self-assembly in nature has inspired remarkable interest in self-assembly of peptides to functional nanomaterials. As a matter of fact, their structural, mechanical, and functional advantages, plus their high bio-compatibility and bio-degradability make them excellent candidates for facilitating biomedical applications. This review focuses on the self-assembly of peptides for the fabrication of antibacterial nanomaterials holding great interest for substituting antibiotics, with emphasis on strategies to achieve nano-architectures of self-assembly. The antibacterial activities achieved by these nanomaterials are also described. View Full-Text
Keywords: self-assembling; peptide; antimicrobial activity; nanomaterial self-assembling; peptide; antimicrobial activity; nanomaterial

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Lombardi, L.; Falanga, A.; Del Genio, V.; Galdiero, S. A New Hope: Self-Assembling Peptides with Antimicrobial Activity. Pharmaceutics 2019, 11, 166.

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