Recent Insights Concerning the Use of Supramolecular Systems for Biomedical Applications

Dear Colleagues,

One of the major goals of scientific research is to develop new tools and methods for improving human health and well-being. In recent years, supramolecular systems have emerged as a promising study area with potential applications in various biomedical fields. Supramolecular systems have attracted significant attention in biomedical research due to their unique properties and versatile functionalities (e.g., their ability to mimic biological systems). These systems, based on non-covalent interactions, offer a wide range of possibilities for applications, such as drug delivery, tissue engineering, wound healing, cancer therapy, and bioimaging. Many researchers have explored various types of supramolecular systems, including hydrogels, nanoplatforms, and polymers, to develop innovative solutions for biomedical challenges. One of the primary areas where supramolecular systems have found great promise is drug delivery. A conventional method of drug delivery involves the use of large doses of drugs that often result in numerous side effects. Additionally, many drugs have poor solubility, limited stability, and low bioavailability, significantly affecting their efficacy. Supramolecular systems solve these challenges by encapsulating drugs within their structures, protecting them from degradation and increasing their solubility. Specific attention is given to supramolecular nanosized systems and their utilization as transporters for the controlled delivery of drugs. These nanotransporters allow the physicochemical and biological properties of drugs to be optimized and facilitate the internalization of drugs at the cellular level, thus offering a controlled and targeted release of drugs.

This Special Issue is dedicated to investigating nanotransporters based on supramolecular systems, containing natural or synthetic bioactive molecules, in which the drug is either absorbed, adsorbed or encapsulated in the carrier, emphasizing their improved biological activity.

With this Special Issue, we aim to collate full papers and review articles on recent developments in the utilization of nanotransporters to improve solubility, biological activity, and physicochemical properties compared to the free drugs, making it a promising candidate for biomedical applications.

Dr. Moaca Alina
Dr. Codruta Soica
Dr. Cristina Trandafirescu
Dr. Cristina A. Dehelean
Guest Editors

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