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Special Issue "Bioactive Compounds"

A special issue of Pharmaceuticals (ISSN 1424-8247).

Deadline for manuscript submissions: closed (28 February 2011)

Special Issue Editors

Guest Editor
Prof. Dr. Isabel C. F. R. Ferreira

Mountain Research Center, School of Agriculture, Polytechnic Institute of Bragança, Campus de Santa Apolónia, apartado 1172, 5301-855 Bragança, Portugal
Website | E-Mail
Interests: food chemistry; bio-based ingredients; natural preservatives/colorants; functional foods; food processing
Guest Editor
Prof. Dr. Nancy D. Turner

Director, TAMU Space Life Sciences Mentored Research Program, Nutrition & Food Science Department, Texas A&M University, 2253 TAMU, 214C Cater Mattil, College Station, TX 77843-2253, USA
Website | E-Mail
Interests: Nutrition, colon cancer, polyphenols, intestinal microbiota, apoptosis

Special Issue Information

Dear Colleagues,

Consumers increasingly believe that foods contribute directly to their health and well-being. In this context, extranutritional constituents that typically occur in small quantities in foods, "Bioactive compounds¡±, play a very significant role. Bioactive compounds are being intensively studied to evaluate their effects on health, including antioxidant, antiallergic, antimicrobial, antithrombotic, antiatherogenic, hypoglycaemic, anti-inflammatory, antitumor, cytostatic, immunosuppressive properties, and hepatoprotective activities. Contributions for this issue, both in form of original research and review articles, may cover all aspects of bioactive compounds with proven activities in various biological screenings and pharmacological models, e.g. quantification, variability and efficacy of bioactive compounds; development of new protocols and methods based on chemical or biological systems for the evaluation of in vivo and in vitro bioactivity; clinical and nutritional trials focused on the bioactive properties of bioactive compounds synthesized or isolated; elucidation of bioactive compounds mechanisms; innovative techniques of bioactive compounds delivery and protocols for the extraction, isolation, structural characterization of new bioactive compounds will be welcomed, on condition that an adequate evaluation of their efficacy is provided. Papers regarding the development of pharmaceuticals from bioactive compounds will be also taken into consideration.

Dr Isabel C.F.R. Ferreira
Guest Editor


  • bioactivity
  • natural products
  • synthesised compounds
  • isolation techniques
  • structure elucidation
  • mechanism of action

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Published Papers (1 paper)

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Open AccessArticle Analysis of Indonesian Spice Essential Oil Compounds That Inhibit Locomotor Activity in Mice
Pharmaceuticals 2011, 4(4), 590-602; https://doi.org/10.3390/ph4040590
Received: 5 January 2011 / Revised: 14 March 2011 / Accepted: 14 March 2011 / Published: 6 April 2011
Cited by 4 | PDF Full-text (279 KB) | HTML Full-text | XML Full-text
Some fragrance components of spices used for cooking are known to have an effect on human behavior. The aim of this investigation was to examine the effect of the essential oils of basil (Ocimum formacitratum L.) leaves, lemongrass (Cymbopogon citrates L.)
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Some fragrance components of spices used for cooking are known to have an effect on human behavior. The aim of this investigation was to examine the effect of the essential oils of basil (Ocimum formacitratum L.) leaves, lemongrass (Cymbopogon citrates L.) herbs, ki lemo (Litsea cubeba L.) bark, and laja gowah (Alpinia malaccencis Roxb.) rhizomes on locomotor activity in mice and identify the active component(s) that might be responsible for the activity. The effect of the essential oils was studied by a wheel cage method and the active compounds of the essential oils were identified by GC/MS analysis. The essential oils were administered by inhalation at doses of 0.1, 0.3, and 0.5 mL/cage. The results showed that the four essential oils had inhibitory effects on locomotor activity in mice. Inhalation of the essential oils of basil leaves, lemongrass herbs, ki lemo bark, and laja gowah rhizomes showed the highest inhibitory activity at doses of 0.5 (57.64%), 0.1 (55.72%), 0.5 (60.75%), and 0.1 mL/cage (47.09%), respectively. The major volatile compounds 1,8-cineole, α-terpineol, 4-terpineol, citronelol, citronelal, and methyl cinnamate were identified in blood plasma of mice after inhalation of the four oils. These compounds had a significant inhibitory effect on locomotion after inhalation. The volatile compounds of essential oils identified in the blood plasma may correlate with the locomotor-inhibiting properties of the oil when administered by inhalation. Full article
(This article belongs to the Special Issue Bioactive Compounds)
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