Dear Colleagues,

The journal “Pharmaceuticals” is planning to publish a special issue covering the topic “New Agents Targeting Regulators of Protein Homeostasis for Cancer Therapy” and I am cordially inviting you to contribute an article to this volume.

Protein homeostasis is essential for many critical cellular processes, including cell cycle progression, signal transduction, and cell death. The ubiquitin-proteasome system controls the turnover of most short-lived intracellular proteins, while autophagy functions as a mechanism for the bulk degradation of organelles and proteins with long half-lives. Protein turnover frequently becomes dysregulated in cancer and aberrant protein degradation contributes to disease progression, metastasis, and drug resistance. As such, targeting abnormal protein degradation in cancer is an appealing therapeutic strategy. A number of agents that inhibit both ubiquitin-proteasome mediated protein turnover and autophagic degradation are currently under investigation for their potential applications in cancer therapy in preclinical studies and clinical trials. This Special Issue will focus on new developments related to targeting regulators of protein turnover as an anticancer strategy.

Dr. Jennifer S. Carew
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.