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Pharmaceuticals 2015, 8(1), 1-20;

Clinical Use of Proteasome Inhibitors in the Treatment of Multiple Myeloma

Internal Medicine, Jane Anne Nohl Division of Hematology, Keck School of Medicine of University of Southern California, Los Angeles, CA 90033, USA
Author to whom correspondence should be addressed.
Academic Editor: Jennifer Carew
Received: 29 July 2014 / Accepted: 4 December 2014 / Published: 24 December 2014
Full-Text   |   PDF [719 KB, uploaded 24 December 2014]


Multiple myeloma (MM) is an incurable hematological malignancy characterized by the clonal proliferation of neoplastic plasma cells. The use of proteasome inhibitors in the treatment of MM has led to significant improvements in outcomes. This article reviews data on the use of the two approved proteasome inhibitors (bortezomib and carlfilzomib), as well as newer agents under development. Emphasis is placed on the clinical use of proteasome inhibitors, including management of side effects and combination with other agents. View Full-Text
Keywords: multiple myeloma; proteasome inhibitors; toxicity multiple myeloma; proteasome inhibitors; toxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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MDPI and ACS Style

Merin, N.M.; Kelly, K.R. Clinical Use of Proteasome Inhibitors in the Treatment of Multiple Myeloma. Pharmaceuticals 2015, 8, 1-20.

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