Bioactive Compounds as Bacterial Efflux Pump Inhibitors
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Natural Products".
Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 1783
Special Issue Editors
Interests: natural products; preclinical research; pharmacology; drug development; inflammatory diseases; antibiotic resistance; antifungals; ethnopharmacology; public health
Special Issues, Collections and Topics in MDPI journals
Interests: natural product; bioctivity; inflammation; pain; antimicrobial activity; pharmacological activity
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Antibiotic resistance is responsible for approximately 700,000 yearly deaths worldwide. Therefore, managing infections caused by resistant bacteria and reducing the associated morbidity and mortality rates currently represent a significant challenge in public healthcare. Efflux pumps (EP) are cell membrane proteins that actively mediate the extrusion of dangerous compounds in various cells. In the context of antibiotic resistance, efflux pump expression stands out for the widespread occurrence among resistant bacterial strains, leading to the lack of effectiveness of a significant number of antibiotics. A large body of research has demonstrated that compounds of either synthetic or natural origin can potentiate the efficacy of conventional antibiotics against EP-overexpressing strains. Therefore, the discovery of bioactive compounds capable of acting as bacterial efflux pump inhibitors represents a promising strategy for combatting antibiotic resistance.
This Special Issue aims to gather manuscripts of all article types demonstrating the effectiveness of fully characterized bioactive compounds as efflux pump inhibitors and their impact on antibiotic resistance, through in vivo, ex vivo in vitro, and in silico testing.
Prof. Dr. Jaime Ribeiro-Filho
Dr. Irwin Rose Alencar Menezes
Guest Editors
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Keywords
- bioactive compounds
- efflux pumps
- bacterial strains
- antibiotic resistance
- drug development
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