Application of Gastrointestinal Peptides in Medicine

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmacology".

Deadline for manuscript submissions: 5 July 2024 | Viewed by 474

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Department of Pathology, School of Medicine, University of Zagreb, Šalata ul. 2, 10000, Zagreb, Croatia
Interests: wound healing; angiogenesis; tissue reaction to injury; carcinogenesis; metastasis
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Department of Pathology, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia
Interests: myelodysplastic syndromes; azacitidine; decitabine

Special Issue Information

Dear Colleagues,

Conceptually, a wide beneficial effect, both peripherally and centrally, might have been essential for the harmony and function of the gut–brain axes. From the original viewpoint of gut peptides' significance and brain relation, these could be favorable behavioral findings (interaction with main systems; anxiolytic, anticonvulsive and antidepressant effects; counteracted catalepsy; and positive and negative schizophrenia symptom models). Further applications are possible in muscle healing and function recovery, both peripherally and centrally mediated muscles disabilities, heart failure including arrhythmias and thrombosis, and smooth muscle function recovery. Finally, encephalopathies, acting simultaneously in both the peripheral and central nervous system, and large lesions in the brain and peripheral organs, can be targets for gut peptide therapy. Severe blood pressure disturbances (i.e., venous (intracranial hypertension, portal and caval hypertension) and arterial (i.e., aortal hypotension or hypertension)) can be targeted by gut peptide therapy. The existence of a multimodal axis in healing as a function of the brain–gut axis and the gut–brain axis as a whole should be revealed by gut peptide therapy.

Prof. Dr. Predrag S. Sikirić
Prof. Dr. Sven Seiwerth
Dr. Anita Škrtić
Guest Editors

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Keywords

  • brain–gut axes
  • gut peptides
  • gut peptide therapy
  • peptides, healing
  • heart failure

Published Papers (1 paper)

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Research

18 pages, 9438 KiB  
Article
(-)-Fenchone Prevents Cysteamine-Induced Duodenal Ulcers and Accelerates Healing Promoting Re-Epithelialization of Gastric Ulcers in Rats via Antioxidant and Immunomodulatory Mechanisms
by Maria Elaine Cristina Araruna, Edvaldo Balbino Alves Júnior, Catarina Alves de Lima Serafim, Matheus Marley Bezerra Pessoa, Michelle Liz de Souza Pessôa, Vitória Pereira Alves, Marcelo Sobral da Silva, Marianna Vieira Sobral, Adriano Francisco Alves, Mayara Karla dos Santos Nunes, Aurigena Antunes Araújo and Leônia Maria Batista
Pharmaceuticals 2024, 17(5), 641; https://doi.org/10.3390/ph17050641 - 15 May 2024
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Abstract
Background: (-)-Fenchone is a naturally occurring monoterpene found in the essential oils of Foeniculum vulgare Mill., Thuja occidentalis L., and Peumus boldus Molina. Pharmacological studies have reported its antinociceptive, antimicrobial, anti-inflammatory, antidiarrheal, and antioxidant activities. Methods: The preventive antiulcer effects of (-)-Fenchone were [...] Read more.
Background: (-)-Fenchone is a naturally occurring monoterpene found in the essential oils of Foeniculum vulgare Mill., Thuja occidentalis L., and Peumus boldus Molina. Pharmacological studies have reported its antinociceptive, antimicrobial, anti-inflammatory, antidiarrheal, and antioxidant activities. Methods: The preventive antiulcer effects of (-)-Fenchone were assessed through oral pretreatment in cysteamine-induced duodenal lesion models. Gastric healing, the underlying mechanisms, and toxicity after repeated doses were evaluated using the acetic acid-induced gastric ulcer rat model with oral treatment administered for 14 days. Results: In the cysteamine-induced duodenal ulcer model, fenchone (37.5–300 mg/kg) significantly decreased the ulcer area and prevented lesion formation. In the acetic acid-induced ulcer model, fenchone (150 mg/kg) reduced (p < 0.001) ulcerative injury. These effects were associated with increased levels of reduced glutathione (GSH), superoxide dismutase (SOD), interleukin (IL)-10, and transforming growth factor-beta (TGF-β). Furthermore, treatment with (-)-Fenchone (150 mg/kg) significantly reduced (p < 0.001) malondialdehyde (MDA), myeloperoxidase (MPO), interleukin-1 beta (IL-1β), tumor necrosis factor-alpha (TNF-α), and nuclear transcription factor kappa B (NF-κB). A 14-day oral toxicity investigation revealed no alterations in heart, liver, spleen, or kidney weight, nor in the biochemical and hematological parameters assessed. (-)-Fenchone protected animals from body weight loss while maintaining feed and water intake. Conclusion: (-)-Fenchone exhibits low toxicity, prevents duodenal ulcers, and enhances gastric healing activities. Antioxidant and immunomodulatory properties appear to be involved in its therapeutic effects. Full article
(This article belongs to the Special Issue Application of Gastrointestinal Peptides in Medicine)
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