Mass Spectrometry-Based Lipidomics in Drugs Discovery
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 322
Special Issue Editors
Interests: mass spectrometry; pharmacology
Special Issue Information
Dear Colleagues,
Several human diseases, such as obesity, cardiovascular disease, cancer, and neurodegeneration, involve changes in lipids and lipid metabolic pathways. Alterations in the expression of different lipid molecules have been used to specify the functionality of various metabolic pathways in disease. In addition, the discoordination of lipids affects the upstream proteomic regulation and interaction. Therefore, many drugs that directly or indirectly affect lipid metabolic pathways can be developed. This information can be employed to identify druggable target enzymes to control the pathway of interest.
Mass spectrometry (MS)-based lipid profiling and analysis, including liquid chromatography–high resolution mass spectrometry (LC-MS), MS imaging, and lipidomic flux analysis, hold tremendous potential in the diagnostic approach along the drug development process.
In this Special Issue, we seek to bring together research from experts in the field, focusing on novel mass spectrometry-based lipidomics techniques and strategies, their applications in targeted-lipid drug discovery and development, and future perspectives that will enhance our biological understanding of molecular lipid metabolism for precise therapeutic opportunities.
Prof. Dr. Hua Tian
Dr. Fereshteh Zandkarimi
Guest Editors
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Keywords
- lipidomics
- drug discovery
- LC-MS
- mass spectrometry imaging
- lipidomic flux analysis
- stable isotope tracing
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