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Pharmaceuticals
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Magnetic Nanoparticles (MNPs) in Biomedical Applications
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Magnetic Nanoparticles (MNPs) in Biomedical Applications

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmaceutical Technology".

Deadline for manuscript submissions: 20 July 2024 | Viewed by 4650

Special Issue Editor

Prof. Dr. Sandile Phinda Songca

E-Mail Website
Guest Editor
Department of Chemistry, University of KwaZulu-Natal, Private Bag X 54001, Durban 4000, South Africa
Interests: combination of photodynamic therapy and magnetic hyperthermia; iron oxide magnetic nanoparticles

Special Issue Information

Dear Colleagues,

Magnetic nanoparticles are currently reshaping medical nanotechnologies and applications. Publications on biomedical applications of magnetic nanoparticles increased by more than three orders of magnitude over the past two decades, with a corresponding increase in patents, clinical trials, clinical applications, and medical devices. Examples include magnetic resonance imaging, magnetic hyperthermia for cancer, bone, brain, liver, and pancreas therapies, targeted drug delivery, tissue engineering, biosensors, and other biomedical applications. Synthetic and characterization approaches have also increased, providing insights into an increasing range of nano-morphologies including spheres, crystals, rods, stars, flowers, wires, and sheets, and these are increasingly engineered into multi-functional nanoconjugates used in bio-environmental and stimulus-responsive drug delivery and release.

Paramagnetic and superparamagnetic metal, alloy, chalcogenide, and ferrite nanoparticles of iron, nickel, cobalt, gadolinium, and other metals are commonly used. Biocompatibility is achieved through polymeric, biomimetic membrane encapsulation, cloaking, and functionalization with target cell membrane and internal component molecules such as aptamers and folate for cancer cell targeting. These developments have led to novel innovations promising reduction of disease burden. The special issue will publish research and review articles on the foregoing and other relevant reflections, perspectives, and research investigations.

The range of articles includes disease detection and diagnosis, therapeutic applications, image-guided theragnostic, combination therapies, design and fabrication of nanoconjugates for biomedical applications, in-vitro, in-vivo, and clinical applications, and biomedical devices. Environmental applications aimed at reducing the burden of disease are considered to be an important part of biomedical disease prevention.

Prof. Dr. Sandile Phinda Songca
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • magnetic nanoparticles
  • magnetic resonance imaging
  • magnetic hyperthermia
  • cancer therapy
  • bone therapy
  • magnetically targeted drug delivery
  • magnetic hyperthermia drug release
  • antimicrobial
  • tissue engineering
  • biosensors

Published Papers (3 papers)

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Research

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18 pages, 4211 KiB  
Article
Evaluation of Antiproliferative Properties of CoMnZn-Fe2O4 Ferrite Nanoparticles in Colorectal Cancer Cells
by Venkatesha Narayanaswamy, Bilal Rah, Imaddin A. Al-Omari, Alexander S. Kamzin, Hafsa Khurshid, Jibran Sualeh Muhammad, Ihab M. Obaidat and Bashar Issa
Pharmaceuticals 2024, 17(3), 327; https://doi.org/10.3390/ph17030327 - 01 Mar 2024
Viewed by 766
Abstract
The PEG-coated ferrite nanoparticles Co0.2Mn0.6Zn0.2Fe2O4 (X1), Co0.4Mn0.4Zn0.2Fe2O4 (X2), and Co0.6Mn0.2Zn0.2Fe2O4 (X3) were synthesized by the coprecipitation [...] Read more.
The PEG-coated ferrite nanoparticles Co0.2Mn0.6Zn0.2Fe2O4 (X1), Co0.4Mn0.4Zn0.2Fe2O4 (X2), and Co0.6Mn0.2Zn0.2Fe2O4 (X3) were synthesized by the coprecipitation method. The nanoparticles were characterized by XRD, Raman, VSM, XPS, and TEM. The magnetic hyperthermia efficiency (MH) was determined for PEG-coated nanoparticles using an alternating magnetic field (AMF). X2 nanoparticles displayed the highest saturation magnetization and specific absorption rate (SAR) value of 245.2 W/g for 2 mg/mL in a water medium. Based on these properties, X2 nanoparticles were further evaluated for antiproliferative activity against HCT116 cells at an AMF of 495.25 kHz frequency and 350 G strength, using MTT, colony formation, wound healing assays, and flow cytometry analysis for determining the cell viability, clonogenic property, cell migration ability, and cell death of HCT116 cells upon AMF treatment in HCT116 cells, respectively. We observed a significant inhibition of cell viability (2% for untreated control vs. 50% for AMF), colony-forming ability (530 cells/colony for untreated control vs. 220 cells/colony for AMF), abrogation of cell migration (100% wound closure for untreated control vs. 5% wound closure for AMF), and induction of apoptosis-mediated cell death (7.5% for untreated control vs. 24.7% for AMF) of HCT116 cells with respect to untreated control cells after AMF treatment. Collectively, these results demonstrated that the PEG-coated (CoMnZn-Fe2O4) mixed ferrite nanoparticles upon treatment with AMF induced a significant antiproliferative effect on HCT116 cells compared with the untreated cells, indicating the promising antiproliferative potential of the Co0.4Mn0.4Zn0.2Fe2O4 nanoparticles for targeting colorectal cancer cells. Additionally, these results provide appealing evidence that ferrite-based nanoparticles using MH could act as potential anticancer agents and need further evaluation in preclinical models in future studies against colorectal and other cancers. Full article
(This article belongs to the Special Issue Magnetic Nanoparticles (MNPs) in Biomedical Applications)
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12 pages, 8102 KiB  
Article
Manipulation of New Fluorescent Magnetic Nanoparticles with an Electromagnetic Needle, Allowed Determining the Viscosity of the Cytoplasm of M-HeLa Cells
by Iliza Ramazanova, Maxim Suslov, Guzel Sibgatullina, Konstantin Petrov, Svetlana Fedorenko, Asiya Mustafina and Dmitry Samigullin
Pharmaceuticals 2023, 16(2), 200; https://doi.org/10.3390/ph16020200 - 29 Jan 2023
Cited by 1 | Viewed by 1679
Abstract
Magnetic nanoparticles (MNPs) have recently begun to be actively used in biomedicine applications, for example, for targeted drug delivery, in tissue engineering, and in magnetic resonance imaging. The study of the magnetic field effect on MNPs internalized into living cells is of particular [...] Read more.
Magnetic nanoparticles (MNPs) have recently begun to be actively used in biomedicine applications, for example, for targeted drug delivery, in tissue engineering, and in magnetic resonance imaging. The study of the magnetic field effect on MNPs internalized into living cells is of particular importance since it allows a non-invasive influence on cellular activity. There is data stating the possibility to manipulate and control individual MNPs utilizing the local magnetic field gradient created by electromagnetic needles (EN). The present work aimed to demonstrate the methodological and technical approach for manipulating the local magnetic field gradient, generated by EN, novel luminescent MNPs internalized in HeLa cancer cells. The controlling of the magnetic field intensity and estimation of the attractive force of EN was demonstrated. Both designs of EN and their main characteristics are also described. Depending on the distance and applied voltage, the attractive force ENs ranged from 0.056 ± 0.002 to 37.85 ± 3.40 pN. As a practical application of the presented, the evaluation of viscous properties of the HeLa cell’s cytoplasm, based on the measurement of the movement rate of MNPs inside cells under impact of a known magnetic force, was carried out; the viscosity was 1.45 ± 0.04 Pa·s. Full article
(This article belongs to the Special Issue Magnetic Nanoparticles (MNPs) in Biomedical Applications)
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Review

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17 pages, 2205 KiB  
Review
Magnetic Hyperthermia Therapy for High-Grade Glioma: A State-of-the-Art Review
by Benjamin Rodriguez, Daniel Rivera, Jack Y. Zhang, Cole Brown, Tirone Young, Tyree Williams, Sakibul Huq, Milena Mattioli, Alexandros Bouras and Constantinos G. Hadjpanayis
Pharmaceuticals 2024, 17(3), 300; https://doi.org/10.3390/ph17030300 - 26 Feb 2024
Viewed by 1251
Abstract
Magnetic hyperthermia therapy (MHT) is a re-emerging treatment modality for brain tumors where magnetic nanoparticles (MNPs) are locally delivered to the brain and then activated with an external alternating magnetic field (AMF) to generate localized heat at a site of interest. Due to [...] Read more.
Magnetic hyperthermia therapy (MHT) is a re-emerging treatment modality for brain tumors where magnetic nanoparticles (MNPs) are locally delivered to the brain and then activated with an external alternating magnetic field (AMF) to generate localized heat at a site of interest. Due to the recent advancements in technology and theory surrounding the intervention, clinical and pre-clinical trials have demonstrated that MHT may enhance the effectiveness of chemotherapy and radiation therapy (RT) for the treatment of brain tumors. The future clinical success of MHT relies heavily on designing MNPs optimized for both heating and imaging, developing reliable methods for the local delivery of MNPs, and designing AMF systems with integrated magnetic particle imaging (MPI) for use in humans. However, despite the progression of technological development, the clinical progress of MHT has been underwhelming. This review aims to summarize the current state-of-the-art of MHT and offers insight into the current barriers and potential solutions for moving MHT forward. Full article
(This article belongs to the Special Issue Magnetic Nanoparticles (MNPs) in Biomedical Applications)
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