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Pharmaceuticals
Special Issues
Antibody-Based Imaging and Targeted Therapy in Cancer
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Antibody-Based Imaging and Targeted Therapy in Cancer

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Radiopharmaceutical Sciences".

Deadline for manuscript submissions: closed (31 March 2025) | Viewed by 5573

Special Issue Editor

Prof. Dr. Hirofumi Hanaoka

E-Mail Website
Guest Editor
Department of Radiotheranostics, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi 371-8511, Japan
Interests: radiopharmaceutical sciences; radionuclide therapy; theranostics; photoimmunotherapy

Special Issue Information

Dear Colleagues,

Antibody-based drugs have shown great potential for cancer imaging and therapy since monoclonal antibodies (mAbs) can selectively deliver substances, such as a radionuclide, dyes, and a toxic molecule to the target. Molecular imaging combines imaging agents with mAbs to specifically image diseased sites in the body. For cancer treatment, cytotoxic payload is conjugated to mAbs to selectively deliver the toxic molecule to cancer cells. Radiolabeled antibody and antibody–drug conjugates (ADCs) consisting of a toxic molecule conjugated to a mAb have been developed and used in clinical practice. Recently, antibody-photoactivating chemical conjugates have been developed as a drug for photoimmunotherapy (PIT). PIT targeting EGFR was approved for clinical use in Japan in 2020.

The development of new antibody-based drugs will make them more useful in cancer treatment. In addition, it is also important to improve the therapeutic effect and/or side effects of drugs by adding modifications or inserting functional linkers.

This Special Issue welcomes research articles and review papers focused on the broad area of development of antibody-based drugs. Research areas may include (but are not limited to) the following: development of new drugs for antibody-based cancer imaging, radioimmunotherapy, ADC, photoimmunotherapy, and novel strategies to improve the therapeutic and/or side effect.

Prof. Dr. Hirofumi Hanaoka
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antibody-based cancer imaging
  • radioimmunotherapy
  • antibody–drug conjugate (ADC)
  • photoimmunotherapy
  • drug delivery system
  • functional linker

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Published Papers (2 papers)

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Review

17 pages, 946 KiB  
Review
Diverse Roles of Antibodies in Antibody–Drug Conjugates
by Aiko Yamaguchi and H. Charles Manning
Pharmaceuticals 2025, 18(2), 180; https://doi.org/10.3390/ph18020180 - 29 Jan 2025
Viewed by 2037
Abstract
The emergence of antibody–drug conjugates (ADCs) has transformed the treatment landscape of a variety of cancers. ADCs typically consist of three main components: monoclonal antibody, chemical linker, and cytotoxic payload. These integrated therapeutic modalities harness the benefits of each component to provide a [...] Read more.
The emergence of antibody–drug conjugates (ADCs) has transformed the treatment landscape of a variety of cancers. ADCs typically consist of three main components: monoclonal antibody, chemical linker, and cytotoxic payload. These integrated therapeutic modalities harness the benefits of each component to provide a therapeutic response that cannot be achieved by conventional chemotherapy. Antibodies play roles in determining tumor specificity through target-mediated uptake, prolonging the circulation half-life of cytotoxic payloads, and providing additional mechanisms of action inherent to the original antibody, thus significantly contributing to the overall performance of ADCs. However, ADCs have unique safety concerns, such as drug-induced adverse events related to the target-mediated uptake of the ADC in normal tissues (so-called “on-target, off-tumor toxicity”) and platform toxicity, which are partially derived from limited tumor uptake of antibodies. Identifying suitable target antigens thus impacts the clinical success of ADCs and requires careful consideration, given the multifaceted aspects of this unique treatment modality. This review briefly summarizes the representative roles that antibodies play in determining the efficacy and safety of ADCs. Key considerations for selecting suitable cell surface target antigens for ADC therapy are also highlighted. Full article
(This article belongs to the Special Issue Antibody-Based Imaging and Targeted Therapy in Cancer)
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Graphical abstract

19 pages, 1894 KiB  
Review
Approaches to Reducing Normal Tissue Radiation from Radiolabeled Antibodies
by Hiroyuki Suzuki, Kento Kannaka and Tomoya Uehara
Pharmaceuticals 2024, 17(4), 508; https://doi.org/10.3390/ph17040508 - 16 Apr 2024
Cited by 4 | Viewed by 2670
Abstract
Radiolabeled antibodies are powerful tools for both imaging and therapy in the field of nuclear medicine. Radiolabeling methods that do not release radionuclides from parent antibodies are essential for radiolabeling antibodies, and practical radiolabeling protocols that provide high in vivo stability have been [...] Read more.
Radiolabeled antibodies are powerful tools for both imaging and therapy in the field of nuclear medicine. Radiolabeling methods that do not release radionuclides from parent antibodies are essential for radiolabeling antibodies, and practical radiolabeling protocols that provide high in vivo stability have been established for many radionuclides, with a few exceptions. However, several limitations remain, including undesirable side effects on the biodistribution profiles of antibodies. This review summarizes the numerous efforts made to tackle this problem and the recent advances, mainly in preclinical studies. These include pretargeting approaches, engineered antibody fragments and constructs, the secondary injection of clearing agents, and the insertion of metabolizable linkages. Finally, we discuss the potential of these approaches and their prospects for further clinical application. Full article
(This article belongs to the Special Issue Antibody-Based Imaging and Targeted Therapy in Cancer)
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