Innovative Tools for Drug Analysis and Therapeutic Drug Monitoring (TDM): 2nd Edition
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmacology".
Deadline for manuscript submissions: 25 August 2026 | Viewed by 289
Editors
2. Department of Galenic Pharmacy, Faculty of Pharmacy, Comenius University in Bratislava, Bratislava, Slovakia
3. Toxicological and Antidoping Center, Faculty of Pharmacy, Comenius University in Bratislava, Bratislava, Slovakia
Interests: capillary electrophoresis; liquid chromatography; mass spectrometry; biologics; therapeutic drug monitoring; bioanalysis; quality control; therapeutic peptides
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2. Department of Galenic Pharmacy, Faculty of Pharmacy, Comenius University in Bratislava, Bratislava, Slovakia
Interests: Alzheimer's disease; neurodegenerative diseases; neurobiology; cell culture; immunohistochemistry; neurodegeneration; neuroscience; neurological diseases; neurobiology and brain physiology; cellular neuroscience
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Therapeutic drug monitoring (TDM) is a measurement of drug concentration in various body fluids or tissues. It represents an effective tool for clinicians to achieve optimal and rational pharmacotherapy. Accurate analyses of drugs in biological fluids (especially serum or urine) and the proper interpretation of drug concentration can significantly improve the treatment management of individual patients, which leads to personalized medicine. Excluding “traditional drugs”, TDM is used for drugs with a well-defined relationship between concentration and effect (either therapeutic or toxic) and drugs with large inter- or intra-individual differences in distribution or clearance. Recently, there has also been a growing need for appropriate analytical methods that identify biologics (therapeutic peptides, monoclonal antibodies, and various protein therapeutics) in the clinical environment.
To determine the levels of modern innovative drugs in biological fluids and/or in dosage forms, accurate analytical methods (e.g., HPLC, CE, and HR-MS) are needed. These methods represent extremely valuable tools in the clinical, quality control, and regulatory settings. They are characterized by robustness, relative simplicity, universality, and high sample throughput, which are extremely desirable attributes for the fast decision-making needed in the setting/adjustment of pharmacotherapy based on TDM.
This second edition of this Special Issue dedicated to “Innovative Tools for Drug Analysis and Therapeutic Drug Monitoring (TDM): 2nd Edition” requires a wide range of contributions that reflect the interdisciplinary nature of TDM and current trends driving this research area forward, such as computational approaches (e.g., modeling, in silico tools, and data-driven methods). Emerging analytical strategies will also be discussed. This Special Issue is strongly focused, but not limited, to the development and validation of analytical strategies (including novel and unique trends in sample preparation procedures) for innovative drugs, i.e., biologics (monoclonal antibodies, oligonucleotides, vaccines, peptides, etc.). Emphasis is also placed on the role of analytical data in personalized pharmacotherapy, including specific examples of clinical decision-making based on therapeutic drug monitoring.
Dr. Juraj Piestansky
Dr. Andrej Kovac
Guest Editors
Manuscript Submission Information
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Keywords
- therapeutic drug monitoring
- biologics
- separation analytical methods
- bioanalysis
- quality control
- dosage forms
- green analytical chemistry
- personalized medicine
- clinical bioanalysis
- bioanalytical methods
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