Antiproliferative Activity of Phytochemicals
A special issue of Pharmaceuticals (ISSN 1424-8247).
Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 5684
Special Issue Editor
Special Issue Information
Dear Colleagues,
Cancer is one of the leading causes of death along with heart and cerebrovascular diseases. It is well known that cancer can be clinically treated with surgery, radiation therapy or chemotherapy. However, in many cases, this does not confer significant long term health benefits upon patients. De facto, after surgical removal of cancerous cells or tumours, however, tumor cell metastases continue to develop, and this is one of the reasons that make it difficult to treat cancer. Numerous studies have shown that radioactive rays and most anti-cancer drugs can damage DNA or suppress DNA duplication to kill or inhibit tumor cell growth. However, these harmful radiation and drugs also affect normal cells, causing serious side effects such as bone marrow suppression, nausea, vomiting, and alopecia. Thus, there is a need for more effective anticancer drugs with high selectivity against malignant cells and with the ability to suppress metastases. Natural metabolites that are produced by various plant tissues have high potential to fulfil this role.
Plants are one of the main sources of biologically active chemical metabolites that may exhibit an antiproliferative effect. Approximately half of the prescription drugs in Europe and the US originate from natural products or their derivatives, as well as their synthetic counterparts. Of the 500,000 plant species with potential medicinal value, only about one percent has been studied chemically and pharmacologically. There are still alot of hidden potential to be unravelled. For example, it is known that extracts of various plant parts, essential oils, alkaloids, steroids, saponins, flavonoids, glycosides, aromatic compounds, lipids, fatty acid amides, nutrient compounds, and/or thier synthetic analogs may exhibit antiproliferative activity.
Authors are invited to submit original and review articles on preclinical or/and clinical studies of various organic metabolites isolated from plants, lichens, algae, or cyanobacteria that demonstrate antiproliferative activity. Submitted papers and reviews will be published in a special issue of Pharmaceuticals: "Antiproliferative Activity of Phytochemicals".
Dr. Valery Mikhail Dembitsky
Guest Editor
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Keywords
- antiproliferative
- anticancer
- apoptosis
- chemotherapy
- phytochemicals
- alkaloids
- steroids
- saponins
- flavonoids
- glycosides
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