Spectroscopic and Thermodynamic Insights into Drug-Protein Interactions
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmacology".
Deadline for manuscript submissions: 30 September 2026 | Viewed by 333
Editors
Interests: fluorescence; UV–Vis; isothermal titration calorimetry (ITC); differential scanning calorimetry (DSC); drug-protein binding mechanisms; thermodynamic profiles; structural changes
Interests: natural products; spectroscopic and spectrometric methods; bioactivity; synthetic methodology
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Special Issue Information
Dear Colleagues,
Understanding the molecular mechanisms underlying drug-protein interactions is crucial for modern pharmacology, drug design, and the prediction of pharmacokinetic properties. This Special Issue is dedicated to the application of spectroscopic and thermodynamic methods to reveal key aspects of the interactions between therapeutic agents and their biomolecular targets.
We welcome original research articles and review papers employing techniques such as UV–Vis spectroscopy, fluorescence spectroscopy, FTIR, NMR, circular dichroism (CD), as well as isothermal titration calorimetry (ITC), differential scanning calorimetry (DSC), and other thermodynamic approaches to characterize binding mechanisms, affinity, stoichiometry, and structural changes. Studies that combine experimental and computational approaches, such as molecular docking and molecular dynamics simulations, are also encouraged.
The aim of this Special Issue is to bring together interdisciplinary research at the interface of biophysics, medicinal chemistry, and pharmacology, contributing to a deeper understanding of drug molecule behavior in biological environments. We particularly encourage submissions related to novel drug candidates, drug repurposing, natural compounds, and biological agents.
We look forward to receiving your scientific contributions to this Special Issue, which focuses on advancing the study of drug-protein interactions through precise spectroscopic and thermodynamic analyses.
Dr. Silviya Marcheva Abarova
Prof. Dr. María J. Ortega
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- drug-protein interaction
- circular dichroism spectroscopy
- isothermal titration calorimetry
- thermodynamic analysis
- fluorescence quenching
- binding constant
- pharmacokinetics
- conformational changes
- spectroscopic binding assay
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