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The T Cell Response to Staphylococcus aureus

Department of Immunology, University Medicine Greifswald, Sauerbruchstraße DZ7, 17475 Greifswald, Germany
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Academic Editor: Rachel McLoughlin
Pathogens 2016, 5(1), 31; https://doi.org/10.3390/pathogens5010031
Received: 11 January 2016 / Revised: 1 March 2016 / Accepted: 8 March 2016 / Published: 17 March 2016
(This article belongs to the Special Issue Staphylococcus Aureus Infection)
Staphylococcus aureus (S. aureus) is a dangerous pathogen and a leading cause of both nosocomial and community acquired bacterial infection worldwide. However, on the other hand, we are all exposed to this bacterium, often within the first hours of life, and usually manage to establish equilibrium and coexist with it. What does the adaptive immune system contribute toward lifelong control of S. aureus? Will it become possible to raise or enhance protective immune memory by vaccination? While in the past the S. aureus-specific antibody response has dominated this discussion, the research community is now coming to appreciate the role that the cellular arm of adaptive immunity, the T cells, plays. There are numerous T cell subsets, each with differing functions, which together have the ability to orchestrate the immune response to S. aureus and hence to tip the balance between protection and pathology. This review summarizes the state of the art in this dynamic field of research. View Full-Text
Keywords: T cell subsets; anti-bacterial defense; adaptive immunity; vaccination T cell subsets; anti-bacterial defense; adaptive immunity; vaccination
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MDPI and ACS Style

Bröker, B.M.; Mrochen, D.; Péton, V. The T Cell Response to Staphylococcus aureus. Pathogens 2016, 5, 31.

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