Special Issue "Muscle Wasting and Cancer: Nutritional Intervention, Multimodal Management and Outcomes"

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".

Deadline for manuscript submissions: closed (15 November 2020) | Viewed by 1574

Special Issue Editor

Prof. Dr. Paula Ravasco
E-Mail Website
Guest Editor
1. University Hospital of Santa Maria, Lisbon, Portugal
2. Centre for Interdisciplinary Research In Health of the Universidade Católica Portuguesa, Lisbon, Portugal
Interests: cancer; cell metabolism; mechanisms of carcinogenesis and cancer progression; cancer-cachexia; outcomes research; medical nutrition and nutritional modulation of anti-neoplastic treatments; body composition

Special Issue Information

Dear Colleagues,

Nutritional wasting and undernutrition can influence treatment outcomes, delay wound healing, worsen muscle function and increase the risk of post-operative complications. It can also impair tolerance and response to antineoplastic treatments, which can in turn lead to extended hospital stays, increase the risk for treatment interruptions, and possibly reduce survival rates. Cancer treatments such as surgery and antineoplastic treatments can also significantly impact patients’ nutritional status and body composition. Chemotherapy and radiotherapy related symptoms occur in more than 50% of patients.

The prevention and management of nutritional wasting is increasingly recognised as a significant element of cancer care. Bearing this in mind, the clinical efforts and priority given to improve treatment outcomes, will logically have to include nutritional management, nutritional interventions and adequacy of body composition. The search for effective nutritional interventions that improve body composition (through the preservation of muscle mass and muscle quality) is of utmost importance for clinicians and patients, given the implications for prognosis. This Special Issue welcomes novel multidisciplinary research aimed at understanding optimal nutrition interventions to revert, prevent and treat nutritional wasting in different cancer types. Original studies and systematic reviews of the literature are welcome, on themes such as:

  • Research on nutritional status, body composition, clinical parameters and their evolution throughout the disease course of different cancers
  • Nutritional interventions, their efficacy and their impact on patient outcomes
  • Metabolic and nutritional alterations that influence patient recovery and survival
  • Intervention studies
  • Multimodal interventions and outcomes
  • Controlled randomised studies
  • Analytical, descriptive and cross-sectional studies
  • Systematic reviews

Prof. Dr. Paula Ravasco
Guest Editor

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  • Nutritional Wasting
  • Cachexia
  • Cancer
  • Multimodal management
  • Cancer Outcomes

Published Papers (1 paper)

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Body Composition and Biochemical Parameters of Nutritional Status: Correlation with Health-Related Quality of Life in Patients with Colorectal Cancer
Nutrients 2020, 12(7), 2110; https://doi.org/10.3390/nu12072110 - 16 Jul 2020
Cited by 3 | Viewed by 1370
Up to 60% of colorectal cancer (CRC) patients develop malnutrition, affecting treatment effectiveness, increasing toxicity, postoperative complications, hospital stay, and worsening health-related quality of life (HRQOL). This cross-sectional study analyzed data from 48 women and 65 men with CRC. We correlated scores of [...] Read more.
Up to 60% of colorectal cancer (CRC) patients develop malnutrition, affecting treatment effectiveness, increasing toxicity, postoperative complications, hospital stay, and worsening health-related quality of life (HRQOL). This cross-sectional study analyzed data from 48 women and 65 men with CRC. We correlated scores of the scales from the questionnaires EORTC (European Organisation for Research and Treatment of Cancer) Quality of Life Questionnaire Core 30 (QLQ)-C30 and Colorectal Cancer module Colorectal 29 (QLQ-CR29) with patients’ body composition and clinical and biochemical indicators of nutritional status. Results: Scores on quality of life were negatively associated with the lymphocyte count (rP = −0.386) and the fat trunk percentage (rP = −0.349) in the women’s group. Scores on the physical and role functioning were inversely associated with the adiposity percentage (rP = −0.486 and rP = −0.411, respectively). In men, total skeletal muscle mass (SMM) was positively associated with emotional functioning (rP = 0.450); the trunk SMM was negatively related to fatigue (rP = −0.586), nausea and vomiting (rP = −0.469), pain (rP = −0.506), and financial difficulties (rP = −0.475); additionally, serum albumin was positively related to physical, emotional, and social functioning scales (rPs = 0.395, 0.453, and 0.363, respectively) and negatively to fatigue (rP = −0.362), nausea and vomiting (rP = −0.387), and appetite loss (rP = −0.347). Among the men, the reduced SMM and biochemical, nutritional parameters were related to low scores on the EORTC QLQ-C30 and QLQ-CR29 functioning scales. In conclusion, in patients with CRC, malnourishment could have a profound effect on the patients’ functionality and QoL (quality of life). Full article
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