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Nutrients
Special Issues
Probiotics, Prebiotics, Postbiotics and Intestinal Barrier Function
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Probiotics, Prebiotics, Postbiotics and Intestinal Barrier Function

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Prebiotics and Probiotics".

Deadline for manuscript submissions: closed (28 February 2022) | Viewed by 35031

Special Issue Editor

Prof. Dr. Xi Ma

E-Mail Website
Guest Editor
State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, No. 2. Yuanmingyuan West Road, Beijing 100193, China
Interests: intestinal barrier; immune; intestinal health; gut microbiota

Special Issue Information

Dear Colleagues,

Problems such as the emergence of drug-resistant genes and compromised food safety caused by the overuse of antibiotics are becoming increasingly prominent. There is an urgent requirement for effective alternatives to antibiotics in the fields of livestock production and human medicines. Many prebiotics and probiotics, such as functional oligosaccharides, Lactobacillus spp., and acidifiers, can effectively replace antibiotics for killing pathogens effectively and enhancing immune functions of the host, and they are cannot easily produce drug-resistance genes. However, the potential mechanisms of prebiotics and probiotics are vague, and thus further studies on revealing the molecular interactions between host health and prebiotics or probiotics intervention are needed. Furthermore, different sources of prebiotics and probiotics have diverse responses on the intestinal barrier function of the host. It is very important to distinguish the specific effects of different probiotics and prebiotics on the intestinal barrier. Meanwhile, it would be reasonable and feasible to prevent or cure clinical disease using the compatibility of different prebiotics and probiotics. Relevant research exploring how to combine different prebiotics and probiotics to achieve maximum beneficial effect should be carried out.

The objective of this proposed Special Issue on “Probiotics, Prebiotics, Postbiotics and Intestinal Barrier Function” is to publish meaningful papers detailing nutritional aspects of probiotics and prebiotics. Particularly, papers (reviews and/or clinical or experimental studies) dealing with the role of probiotics and prebiotics in the regulation of intestinal barrier function will be included.

Prof. Dr. Xi Ma
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antibiotics
  • drug-resistance gene
  • disease
  • gut health
  • microbiota community
  • human medicine
  • prebiotics
  • probiotics

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Published Papers (3 papers)

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Research

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18 pages, 3933 KiB  
Article
Effect of Enterococcus faecium NCIMB 10415 on Gut Barrier Function, Internal Redox State, Proinflammatory Response and Pathogen Inhibition Properties in Porcine Intestinal Epithelial Cells
by Nikolett Palkovicsné Pézsa, Dóra Kovács, Péter Gálfi, Bence Rácz and Orsolya Farkas
Nutrients 2022, 14(7), 1486; https://doi.org/10.3390/nu14071486 - 2 Apr 2022
Cited by 8 | Viewed by 3326
Abstract
In farm animals, intestinal diseases caused by Salmonella spp. and Escherichia coli may lead to significant economic loss. In the past few decades, the swine industry has largely relied on the prophylactic use of antibiotics to control gastrointestinal diseases. The development of antibiotic [...] Read more.
In farm animals, intestinal diseases caused by Salmonella spp. and Escherichia coli may lead to significant economic loss. In the past few decades, the swine industry has largely relied on the prophylactic use of antibiotics to control gastrointestinal diseases. The development of antibiotic resistance has become an important issue both in animal and human health. The use of antibiotics for prophylactic purposes has been banned, moreover the new EU regulations further restrict the application of antibiotics in veterinary use. The swine industry seeks alternatives that are capable of maintaining the health of the gastrointestinal tract. Probiotics offer a promising alternative; however, their mode of action is not fully understood. In our experiments, porcine intestinal epithelial cells (IPEC-J2 cells) were challenged by Salmonella Typhimurium or Escherichia coli and we aimed at determining the effect of pre-, co-, and post-treatment with Enterococcus faecium NCIMB 10415 on the internal redox state, paracellular permeability, IL-6 and IL-8 secretion of IPEC-J2 cells. Moreover, the adhesion inhibition effect was also investigated. Enterococcus faecium was able to reduce oxidative stress and paracellular permeability of IPEC-J2 cells and could inhibit the adhesion of Salmonella Typhimurium and Escherichia coli. Based on our results, Enterococcus faecium is a promising candidate to maintain the health of the gastrointestinal tract. Full article
(This article belongs to the Special Issue Probiotics, Prebiotics, Postbiotics and Intestinal Barrier Function)
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12 pages, 1775 KiB  
Article
Impacts of Fructose on Intestinal Barrier Function, Inflammation and Microbiota in a Piglet Model
by Pingting Guo, Haichao Wang, Linbao Ji, Peixia Song and Xi Ma
Nutrients 2021, 13(10), 3515; https://doi.org/10.3390/nu13103515 - 6 Oct 2021
Cited by 17 | Viewed by 3641
Abstract
The metabolic disorder caused by excessive fructose intake was reported extensively and often accompanied by intestinal barrier dysfunction. And the rising dietary fructose was consumed at an early age of human. However, related researches were almost conducted in rodent models, while in the [...] Read more.
The metabolic disorder caused by excessive fructose intake was reported extensively and often accompanied by intestinal barrier dysfunction. And the rising dietary fructose was consumed at an early age of human. However, related researches were almost conducted in rodent models, while in the anatomy and physiology of gastrointestinal tract, pig is more similar to human beings than rodents. Hence, weaned piglets were chosen as the model animals in our study to investigate the fructose’s impacts on intestinal tight junction, inflammation response and microbiota structure of piglets. Herein, growth performance, inflammatory response, oxidation resistance and ileal and colonic microbiota of piglet were detected after 35-day fructose supplementation. Our results showed decreased tight junction gene expressions in piglets after fructose addition, with no obvious changes in the growth performance, antioxidant resistance and inflammatory response. Moreover, fructose supplementation differently modified the microbiota structures in ileum and colon. In ileum, the proportions of Streptococcus and Faecalibacterium were higher in Fru group (fructose supplementation). In colon, the proportions of Blautia and Clostridium sensu stricto 1 were higher in Fru group. All the results suggested that tight junction dysfunction might be an earlier fructose-induced event than inflammatory response and oxidant stress and that altered microbes in ileum and colon might be the potential candidates to alleviate fructose-induced intestinal permeability alteration. Full article
(This article belongs to the Special Issue Probiotics, Prebiotics, Postbiotics and Intestinal Barrier Function)
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Review

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23 pages, 8768 KiB  
Review
Effects and Mechanisms of Probiotics, Prebiotics, Synbiotics, and Postbiotics on Metabolic Diseases Targeting Gut Microbiota: A Narrative Review
by Hang-Yu Li, Dan-Dan Zhou, Ren-You Gan, Si-Yu Huang, Cai-Ning Zhao, Ao Shang, Xiao-Yu Xu and Hua-Bin Li
Nutrients 2021, 13(9), 3211; https://doi.org/10.3390/nu13093211 - 15 Sep 2021
Cited by 247 | Viewed by 26923
Abstract
Metabolic diseases are serious threats to public health and related to gut microbiota. Probiotics, prebiotics, synbiotics, and postbiotics (PPSP) are powerful regulators of gut microbiota, thus possessing prospects for preventing metabolic diseases. Therefore, the effects and mechanisms of PPSP on metabolic diseases targeting [...] Read more.
Metabolic diseases are serious threats to public health and related to gut microbiota. Probiotics, prebiotics, synbiotics, and postbiotics (PPSP) are powerful regulators of gut microbiota, thus possessing prospects for preventing metabolic diseases. Therefore, the effects and mechanisms of PPSP on metabolic diseases targeting gut microbiota are worth discussing and clarifying. Generally, PPSP benefit metabolic diseases management, especially obesity and type 2 diabetes mellitus. The underlying gut microbial-related mechanisms are mainly the modulation of gut microbiota composition, regulation of gut microbial metabolites, and improvement of intestinal barrier function. Moreover, clinical trials showed the benefits of PPSP on patients with metabolic diseases, while the clinical strategies for gestational diabetes mellitus, optimal formula of synbiotics and health benefits of postbiotics need further study. This review fully summarizes the relationship between probiotics, prebiotics, synbiotics, postbiotics, and metabolic diseases, presents promising results and the one in dispute, and especially attention is paid to illustrates potential mechanisms and clinical effects, which could contribute to the next research and development of PPSP. Full article
(This article belongs to the Special Issue Probiotics, Prebiotics, Postbiotics and Intestinal Barrier Function)
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