Special Issue "Nutritional Intake in Patients with Crohn’s Disease"

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".

Deadline for manuscript submissions: 31 March 2021.

Special Issue Editors

Dr. Giuseppe Chiarioni
Guest Editor
Division of Gastroenterology of the University of Verona, AOUI Verona, Verona, Italy and Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Interests: inflammatory bowel disease; celiac disease; short bowel syndrome; chronic pancreatitis; functional gastrointestinal disorders
Dr. Roberto De Giorgio
Guest Editor
Department of Morphology, Surgery and Experimental Medicine, Internal Medicine Unit, St.Anna Hospital, Via Aldo Moro, 8 – 44124 Ferrara, Italy
Interests: celiac disease; non celiac gluten; wheat sensitivity; intestinal insufficiency; short bowel syndrome; inflammatory bowel disease; acute/chronic pancreatitis; severe functional gastrointestinal disorders

Special Issue Information

Dear Colleagues,

The intestinal absorption impairment of nutrients and essential vitamins represents one of the most challenging clinical problems in the majority of patients with Crohn’s disease (CD). The inflammatory involvement in CD may extend throughout the length of the small bowel to the classic segmental localization in the terminal ileum, thus impairing nutrient absorption and processing. However, during the flare of the disease, a number of complications related to intestinal malabsorption become evident, such as malnutrition, dehydration and sarcopenia. The scenario could also be worsened by the best care option, which includes steroids and artificial nutrition. In addition, recent evidence suggests that both bowel inflammation and malnutrition may adversely affect the microbiota, thus contributing to disease activity. A number of patients also report a subjective perception of foods aggravating symptoms to justify restrictive diet measures. In this regard, there is an unmet need of solid scientific data about dietary supplements potentially contributing to the “healthy” small bowel function in active and quiescent CD. In paediatric studies, dietary treatment has been shown to improve bowel inflammation and nutritional status, but adult population data are lacking. It is time to gather relevant experience to thoroughly address nutritional deficiencies in adult and pediatric CD patients. The impact of the nutritional conditions on CD activity, as well as the influence on quality of life, is likely profound. The burden of Crohn’s disease on the wellbeing of reproductive age is also dependent on vitamin absorption, requiring clinical monitoring and adequate supplementation when necessary.  

This Special Issue of Nutrients, entitled “Nutritional intake in patients with Crohn Disease”, welcomes the submission of original research, narrative and systematic reviews and meta-analyses, dealing with the nutritional management of CD in both adult and pediatric populations.

Dr. Giuseppe Chiarioni
Dr. Roberto De Giorgio
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Crohn’s Disease
  • Malnutrition
  • Dietary Supplements
  • Dietary Modifications
  • Enteral Nutrition
  • Parenteral Nutrition
  • Nutrient Deficiency in Crohn’s Disease

Published Papers (1 paper)

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Open AccessReview
Diet Advice for Crohn’s Disease: FODMAP and Beyond
Nutrients 2020, 12(12), 3751; https://doi.org/10.3390/nu12123751 - 06 Dec 2020
Viewed by 1165
Crohn’s disease (CD) is a chronic, progressive, and destructive granulomatous inflammatory bowel disorder that can involve any part of the gastrointestinal tract. It has been presumed that different types of diet might improve gastrointestinal symptoms in CD patients. The aim of this review [...] Read more.
Crohn’s disease (CD) is a chronic, progressive, and destructive granulomatous inflammatory bowel disorder that can involve any part of the gastrointestinal tract. It has been presumed that different types of diet might improve gastrointestinal symptoms in CD patients. The aim of this review was to clarify the efficiency and indications of a low-“fermentable oligo-, di-, mono-saccharides and polyols” (FODMAP) diet (LFD) in CD and to further analyze the available data on other types of diets. PubMed, Cochrane Library, EMBASE and WILEY databases were screened for relevant publications regarding the effect of FODMAP diets on CD. Our search identified 12 articles analyzing the effect of an LFD in CD, 5 articles analyzing the effect of a Mediterranean diet (MD), 2 articles analyzing the effect of a vegetarian diet (VD), and 2 articles analyzing the effect of a low-lactose diet (LLD). The majority of the studies included in this review show the significant efficiency of the LFD in CD patients. We found significant evidence demonstrating that the LFD has a favorable impact on gastrointestinal symptoms in CD patients. Notwithstanding the evidence, it remains to be established if an LFD is more efficient than other types of diets in the short term and especially in the long term. Full article
(This article belongs to the Special Issue Nutritional Intake in Patients with Crohn’s Disease)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: The protective role of Vitamin D for sarcopenia treatment and prevention in patients with Crohn disease
Authors: Marco Domenicali
Affiliation: University of Bologna

Title: Nutraceutical approach to Crohn disease
Authors: Giancarlo Sarnelli
Affiliation: University of Napoli

Title: Nutritional Treatment of Crohn's Disease
Authors: Giorgio Zoli
Affiliation: University of Ferrara

Title: Obesity and Bariatric Surgery in Crohn's Disease
Authors: Marco Milone
Affiliation: University of Naples "Federico II"

Title: Dietary Management of Pediatric Crohn's Disease
Authors: Paolo Lionetti
Affiliation: University of Firenze

Title: Beyond Artificial Nutrition and Biologics: Advanced therapies for Inflammatory Bowel Disease
Authors: Giuseppe Chiarioni
Affiliation: Division of Gastroenterology of the University of Verona, AOUI Verona, Verona, Italy

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