Dear Colleagues,

Articular dysfunction has become a major health issue, with a strong socioeconomic impact and a growing prevalence among the aging population. Osteoarthritis (OA) represents the most common inflammatory joint disease, affecting 20% of the general population and almost 50% of people aged 65 and older. The mechanisms of OA have been extensively investigated, but OA management needs improvement. Today, pharmacological approaches remain the standard, but they are only able to alleviate inflammation and pain. They do not slow down, stop, or reverse the progression of cartilage degradation. Moreover, most of these drug-based approaches are associated with side effects, including bleeding, ulceration, edema, or kidney failure. In this context, alternative strategies are required. Nutrients and micronutrients may be associated with health benefits, especially for the prevention of inflammatory and age-related diseases. However, the best candidates and their modes of action, especially at the clinical level, remain to be further investigated and documented.

Dr. Yohann Wittrant
Guest Editor

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• nutrients
• micronutrients
• polyphenols
• vitamins
• proteins
• FFAs
• osteoarthritis
• aging
• inflammation
• cartilage degradation
• arthralgia
• pain
• chondrocytes
• human data