Special Issue "Metabolic Adaptations to Diet and Physical Activity"

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: 30 September 2020.

Special Issue Editor

Prof. Gregory C. Bogdanis
E-Mail Website
Guest Editor
School of Physical Education and Sports Science, National and Kapodistrian University of Athens, Athens, Greece.
Interests: muscle metabolism; muscle fatigue and recovery; muscle damage; oxidative stress; high-intensity interval training; neuromuscular performance; eccentric exercise

Special Issue Information

Dear Colleagues,

Physical activity, ranging from low-intensity occupational or leisure-time movement to moderate- or high-intensity exercise, requires energy at different rates. These fluctuations in energy expenditure determine the contribution of lipid and carbohydrate metabolism and induce acute and chronic metabolic responses and adaptations which improve health and performance.

Diet includes not only the amount and quality of nutrients consumed daily by an individual, but also their manipulations aiming to promote weight loss, health, and physical performance.

In this Special Issue of Nutrients entitled “Metabolic Adaptations to Diet and Physical Activity”, we aim to bring together papers that examine acute or chronic metabolic adaptations to exercise and diet, as well as their interaction.

We welcome different types of manuscript submissions, including original research articles, systematic reviews, and meta-analyses.

Potential topics may include, but are not limited, to the associations between macronutrients and micronutrients intake (or manipulation), dietary patterns, and the entire spectrum of physical activity (from light to high-intensity exercise). The outcome variables may be health-related metabolic adaptations, including metabolic and body composition changes, hormonal responses, as well as molecular mechanisms responsible for metabolic adaptations.

Prof. Gregory C. Bogdanis
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Physical activity
  • Molecular mechanisms
  • Hormonal responses
  • Health
  • Nutrition
  • Carbohydrate metabolism
  • Muscle glycogen
  • Fat metabolism
  • Diet
  • Obesity

Published Papers (1 paper)

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Open AccessArticle
The Effect of an 8 Week Prescribed Exercise and Low-Carbohydrate Diet on Cardiorespiratory Fitness, Body Composition and Cardiometabolic Risk Factors in Obese Individuals: A Randomised Controlled Trial
Nutrients 2020, 12(2), 482; https://doi.org/10.3390/nu12020482 (registering DOI) - 14 Feb 2020
Background: Low-carbohydrate (LC) diets are an effective method for treating obesity and reducing cardiometabolic risk. However, exposure to LC diets is associated with reductions in muscle mass and increased osteoporosis risk in obese individuals. The combination of exercise with a LC diet appears [...] Read more.
Background: Low-carbohydrate (LC) diets are an effective method for treating obesity and reducing cardiometabolic risk. However, exposure to LC diets is associated with reductions in muscle mass and increased osteoporosis risk in obese individuals. The combination of exercise with a LC diet appears to attenuate muscle mass loss induced by LC diets alone, and to further improve cardiometabolic profile. However, evidence to date in obese individuals is limited. We assessed the effect of LC diet in combination with supervised exercise on cardiorespiratory fitness, body composition and cardiometabolic risk factors in obese individuals. Methods: Male and female participants in the experimental (EX-LC; structured supervised exercise program + low-carbohydrate meals; n = 33; 35.3 years) and control (EX-CO; structured supervised exercise program + standard dietary advice; n = 31; 34.2 years) conditions underwent measurements of cardiorespiratory fitness (VO2peak), body fat, lean muscle mass (LMM), and cardiometabolic biomarkers before and after an 8 week intervention. Results: Participants in the EX-LC condition demonstrated greater improvements in VO2peak (p = 0.002) and fat mass index (FMI, p = 0.001) compared to the EX-CO condition. Achieving a ketogenic state (β-hydroxybutyrate, βHB ≥0.3 mmol/L) was associated with greater reductions in total body fat (p = 0.011), visceral adipose tissue (p = 0.025), FMI (p = 0.002) and C-reactive protein (CRP, p = 0.041) but also with greater reductions in LMM (p = 0.042). Conclusion: Short-term LC diet combined with prescribed exercise enhanced cardiorespiratory fitness and the cardiometabolic profile of obese individuals but was also associated with greater muscle mass loss compared to similar exercise training and standard dietary advice. The long-term effects of the LC diet should be further explored in future studies. Full article
(This article belongs to the Special Issue Metabolic Adaptations to Diet and Physical Activity)
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