The Effect of Nutrient Regulation on Metabolic Flexibility in the Presence of Obesity and Related Complications

Dear Colleagues,

The ability of an organism to efficiently adapt its fuel oxidation to fuel availability is termed metabolic flexibility. The capacity to maintain energy homeostasis in times of caloric excess or restriction is dependent on metabolic flexibility. Disruption of this physiological adaptability is associated with many chronic pathologies, including the metabolic syndrome, type 2 diabetes, metabolic fatty liver disease, and cancer.

The metabolic inflexibility of obesity is part of the insulin-resistant state that has been implicated in the development of chronic pathologies. Dietary composition with or without changes in feeding frequency or duration are some factors which influence metabolic flexibility.

In this Special Issue, we invite research papers focusing on the dietary approaches, food composition, and/or patterns of food intake that influence metabolic flexibility in the context of increased adiposity. Articles that shed light on how these factors can modulate obesity-linked chronic diseases and their associated pathologies are welcome

Dr. Michael W. Greene
Guest Editor

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