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Nutritional Support and Care for Pediatric Gastroenterology

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Pediatric Nutrition".

Deadline for manuscript submissions: 31 August 2026 | Viewed by 634

Special Issue Editors


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Guest Editor
Department of Paediatric Hepatology Gastroenterology and Transplantation, Papa Giovanni XXIII Hospital, 24127 Bergamo, Italy
Interests: celiac disease; functional gastrointestinal disorders; eosinophilic esophagitis; chronic inflammatory intestinal diseases; Crohn's disease; ulcerative colitis

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Guest Editor
IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy
Interests: childcare and complementary feeding; acute and chronic childhood illnesses (respiratory, gastrointestinal, and systemic diseases); breastfeeding and feeding issues; child health assessments

Special Issue Information

Dear Colleagues,

Optimal nutritional support plays a fundamental role in the management of pediatric gastrointestinal (GI) disorders, influencing both short- and long-term clinical outcomes. Children with conditions such as inflammatory bowel disease (IBD), celiac disease, eosinophilic esophagitis (EoE), and functional GI disorders face complex nutritional challenges that require individualized and multidisciplinary care.

Celiac disease, a lifelong autoimmune disorder triggered by gluten, necessitates strict adherence to a gluten-free diet to ensure intestinal healing and prevent complications. Nutritional monitoring is essential to detect hidden deficiencies, support growth, and maintain dietary compliance. Eosinophilic esophagitis, characterized by chronic esophageal inflammation due to food allergens, often requires targeted elimination diets or elemental nutrition strategies. These interventions must be carefully managed to ensure adequate intake and avoid nutritional imbalances. Pediatric IBDs, including Crohn’s disease and ulcerative colitis, are often associated with malnutrition, delayed puberty, and linear growth failure. Optimizing macro- and micronutrient intake is essential to supporting mucosal healing and growth.

This Special Issue aims to explore evidence-based approaches to nutritional assessment, intervention, and long-term monitoring in pediatric gastroenterology. Topics of interest include enteral nutrition, therapeutic diets, the role of gut microbiota, caregiver education, and global disparities in care. We welcome the submission of original research, reviews, clinical case studies, and practice guidelines to enhance our understanding and promote comprehensive, patient-centered nutritional support for children with GI diseases.

Dr. Naire Sansotta
Dr. Chiara Maria Trovato
Guest Editors

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Keywords

  • celiac disease
  • inflammatory bowel disease
  • eosinophilic disorders
  • functional gastrointestinal disease
  • enteral nutrition
  • gluten-free diet
  • growth
  • microbiota
  • malnutrition
  • mucosal healing
  • quality of life

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Published Papers (1 paper)

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Research

17 pages, 314 KB  
Article
The Oxidative Stress Imbalance in Children and Adults with IBD and Associated Factors
by Sara Quattrini, Tiziana Galeazzi, Chiara Monachesi, Alessandra Palpacelli, Giulia Catassi, Claudia Quatraccioni, Giulia Annulli, Antonio Di Sario, Laura Cianfruglia, Monia Orciani, Tatiana Armeni, Andrea Faragalli, Rosaria Gesuita, Maria Elena Lionetti, Carlo Catassi and Simona Gatti
Nutrients 2026, 18(9), 1458; https://doi.org/10.3390/nu18091458 - 1 May 2026
Viewed by 321
Abstract
Background/Objectives: An imbalance in oxidative stress (OS) has been implicated in the pathogenesis of Inflammatory Bowel Disease (IBD). We compared OS status in IBD children and adults versus healthy controls by exploring variables impacting the OS disruption in IBD. Methods: Total [...] Read more.
Background/Objectives: An imbalance in oxidative stress (OS) has been implicated in the pathogenesis of Inflammatory Bowel Disease (IBD). We compared OS status in IBD children and adults versus healthy controls by exploring variables impacting the OS disruption in IBD. Methods: Total antioxidant capacity (ferric-reducing ability of plasma (FRAP)), reactive species (ROS), oxidative products (advanced oxidation protein products (AOPPs) and thiobarbituric acid reactive substances (TBARSs)), and antioxidant defenses (glutathione, GSH and intracellular activity of the main antioxidant enzymes) were evaluated. Correlations between OS markers, clinical features, disease characteristics, and inflammatory indices were explored. Results: Eighty-two IBD patients (67.5% in clinical remission) and 73 healthy subjects were enrolled. IBD children showed significant FRAP reduction compared to controls and IBD adults (p < 0.0001), increased AOPPs and reduced GSH compared to controls (p < 0.0001 and p = 0.0011, respectively), higher total GSH (p = 0.020), and lower TBARSs (p = 0.023) compared to IBD adults. In the pediatric group, FRAP was significantly reduced in those with IBD and increased in older subjects and males, while AOPP levels were positively affected by increasing age. In the total IBD cohort, higher FRAP was associated with male gender, increasing age, overweight, and mesalazine therapy. The diagnosis of Ulcerative Colitis was associated with lower FRAP and AOPP levels compared to Crohn’s disease. Increased fecal calprotectin significantly decreased the total antioxidant capacity. Conclusions: The antioxidant system shows significant differences in IBD compared to controls, particularly in the pediatric group. The observed pediatric–adult pattern may suggest age-related differences in oxidative balance, but these findings should be interpreted with caution, given the modest sample size. Clinical Trial Registration Number: NCT04513015. Full article
(This article belongs to the Special Issue Nutritional Support and Care for Pediatric Gastroenterology)
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