Understanding the Metabolic Disease Landscape — Diet or Genes or Both?
A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrigenetics and Nutrigenomics".
Deadline for manuscript submissions: 15 April 2026 | Viewed by 831
Special Issue Editors
2. Laboratory of Cytogenetics and Molecular Genetics, Independent Public Clinical Hospital No. 1 in Zabrze, Medical University of Silesia in Katowice, 41-800 Zabrze, Poland
Interests: metabolic diseases; diabetes; obesity; osteoporosis; metabolic syndrome; genetic risk factor; molecular diagnostics; genotyping; nutrigenomics
Special Issues, Collections and Topics in MDPI journals
Interests: metabolic syndrome; oxidative stress; nutritional pro-oxidants and anti-oxidants; next generating sequence; autopgahy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Our bodies undergo a myriad of changes that influence not only our physical health, but also our metabolic processes. One of the most significant factors of this is the interaction between genetics, diet, and environmental influences, which collectively shape the metabolic landscape and can predispose individuals to a variety of metabolic diseases. These include conditions such as obesity, diabetes, hypertension, non-alcoholic fatty liver disease, cardiovascular diseases, and hypercholesterolaemia, as well as osteoporosis, which are commonly observed in certain populations. Despite these widespread trends, some individuals live without experiencing major health issues, raising a critical question: why do some people maintain good health while others develop diseases earlier in life?
This Special Issue seeks to explore the intricate relationship between diet, genetics, the metabolome, and the microbiome, as well as metabolic diseases, particularly as they relate to different sexes and ages. We encourage contributions from researchers across multiple disciplines, ranging from basic science to clinical studies, that examine the metabolic pathways and mechanisms involved in different sexes and ages. Particular attention will be given to the role of environmental (external and internal, such as microbiome) and nutritional factors in modulating these pathways, as well as the impact of inflammation and oxidative stress in age-related metabolic disorders.
Key Topics of Interest for This Special Issue
- The genetic basis of metabolic diseases and their interactions with diet and lifestyle factors.
- The impact of genetic variants and nutritional factors on the development and progression of metabolic diseases.
- Evaluations of both genetic and nutritional factors in modulating treatment strategies for metabolic diseases.
- Designing personalized treatment plans based on genetic predispositions and nutritional factors.
- Metabolic pathways involved in aging, obesity, hypertension, and insulin resistance.
- The role of oxidative stress and inflammation in age-related metabolic dysfunction.
- The effects of nutritional status and environmental exposures on metabolic health during aging.
- Novel therapeutic approaches targeting metabolic pathways to promote healthy aging.
We invite researchers to contribute original articles, reviews, and clinical studies that examine the interplay between genetics, diet, and metabolic diseases in the context of aging. The goal of this Special Issue is to foster a comprehensive understanding of how these factors converge to influence metabolic health, aging processes, and the development of related diseases, with the ultimate aim of promoting healthy, successful aging.
We look forward to your valuable contributions to this important area of research.
Dr. Sylwia Górczyńska-Kosiorz
Dr. Sylwia Dzięgielewska-Gęsiak
Guest Editors
Manuscript Submission Information
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Keywords
- diabetes
- obesity
- metabolic syndrome
- metabolic bone disease
- diet-related diseases
- genetic risk
- genotyping
- autophagy
- nutrigenomics
- next-generation sequencing
- oxidative stress
- microbiome
- nutrients
- personalized treatment
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