Special Issue "Vitamin C in the Critically Ill, Effects on Oxidative Stress and the Immune System"
A special issue of Nutrients (ISSN 2072-6643).
Deadline for manuscript submissions: closed (30 June 2019) | Viewed by 63625
Vitamin C is crucial for life. Humans have lost the ability to synthesize this simple molecule and depend on nutritional intake to maintain body stores. Deficiency is no more a historical disease, but develops daily in critically-ill patients. Overwhelming oxidative stress and systemic inflammation confer scurvy-like vitamin C concentrations.
Vitamin C has a myriad of functions. As primary circulating antioxidant, cofactor for mono- and dioxygenase enzymes, mitigator of the inflammatory response with immune supporting properties, vitamin C protects vascular and organ cells and may thereby promote patient recovery. Up to now, deficiency goes unnoticed because an assessment of vitamin C status is not available in clinical practice. While older studies show that repletion of vitamin C improves recovery from organ failure, two recent small controlled trials in severe sepsis have additionally shown an impressive reduction in mortality when pharmacological doses of vitamin C were administered alone or in combination with thiamine and hydrocortisone. However, many questions remain.
It is our pleasure to invite researchers to provide contributions reporting clinical or preclinical research or updated reviews for a Special Issue of Nutrients entitled “Vitamin C in the Critically Ill, Effects on Oxidative Stress and the Immune System”. Manuscript elucidating mechanisms of action, metabolism and recycling, assessment of deficiency, dosing, timing and side effects of vitamin C or combination strategies are very welcome.
Prof. Heleen M Oudemans-van Straaten
Dr. Angelique M.E. Spoelstra-de Man
Manuscript Submission Information
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- Vitamin C
- Critically ill
- Intensive care
- Ischemia reperfusion