Special Issue "Vitamin C in the Critically Ill, Effects on Oxidative Stress and the Immune System"
A special issue of Nutrients (ISSN 2072-6643).
Deadline for manuscript submissions: closed (30 June 2019).
Vitamin C is crucial for life. Humans have lost the ability to synthesize this simple molecule and depend on nutritional intake to maintain body stores. Deficiency is no more a historical disease, but develops daily in critically-ill patients. Overwhelming oxidative stress and systemic inflammation confer scurvy-like vitamin C concentrations.
Vitamin C has a myriad of functions. As primary circulating antioxidant, cofactor for mono- and dioxygenase enzymes, mitigator of the inflammatory response with immune supporting properties, vitamin C protects vascular and organ cells and may thereby promote patient recovery. Up to now, deficiency goes unnoticed because an assessment of vitamin C status is not available in clinical practice. While older studies show that repletion of vitamin C improves recovery from organ failure, two recent small controlled trials in severe sepsis have additionally shown an impressive reduction in mortality when pharmacological doses of vitamin C were administered alone or in combination with thiamine and hydrocortisone. However, many questions remain.
It is our pleasure to invite researchers to provide contributions reporting clinical or preclinical research or updated reviews for a Special Issue of Nutrients entitled “Vitamin C in the Critically Ill, Effects on Oxidative Stress and the Immune System”. Manuscript elucidating mechanisms of action, metabolism and recycling, assessment of deficiency, dosing, timing and side effects of vitamin C or combination strategies are very welcome.
Prof. Heleen M Oudemans-van Straaten
Dr. Angelique M.E. Spoelstra-de Man
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Vitamin C
- Critically ill
- Intensive care
- Ischemia reperfusion