Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
9.0
5.9
Journals
Nutrients
Special Issues
The Ketogenic Diet for Cancer
nutrients-logo
Submit to Nutrients Review for Nutrients Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

The Ketogenic Diet for Cancer

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: closed (15 February 2022) | Viewed by 16751

Special Issue Editor

Dr. Keisuke Hagihara

E-Mail Website
Guest Editor
Department of Advanced Hybrid Medicine, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan
Interests: ketogenic diet; cancer; frailty; sarcopenia

Special Issue Information

Dear Colleagues,

Currently, the high-fat, low-carbohydrate ketogenic diet is attracting a great deal of attention in the field of cancer treatment. As metabolic alterations, e.g. the Warburg effect, are widespread in various cancer cells, the ketogenic diet is expected to improve the quality of life and prognosis of cancer patients. As Guest Editor of this timely Special Issue, I would like to invite you to contribute your original research articles or reviews on the ketogenic diet for cancer. In several preclinical studies of cancer model mice, the ketogenic diet alongside radiation or chemotherapy is promising. However, the results of early clinical trials of the ketogenic diet are controversial. I would like to discuss the molecular mechanisms of the ketogenic diet for cancer and the comparison with epilepsy therapy in children. I have shown the possibility of the new ketogenic diet regimen for cancer. I also would like to discuss the possibility of early clinical trial/case series and the adequate clinical trial protocol of the ketogenic diet for cancer. For that purpose, I also look forwards to reports on functional foods inducing ketones more efficiently. I invite you to contribute to our understanding of the above topics for this Special Issue relating to the ketogenic diet for cancer.

Dr. Keisuke Hagihara
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • molecular mechanism
  • early clinical trial or case series
  • clinical trial protocol
  • functional food
  • comparison between cancer and epilepsy treatment.

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review, Other

17 pages, 2990 KiB  
Article
Ketogenic Effects of Multiple Doses of a Medium Chain Triglycerides Enriched Ketogenic Formula in Healthy Men under the Ketogenic Diet: A Randomized, Double-Blinded, Placebo-Controlled Study
by Kentaro Nakamura, Keisuke Hagihara, Naoko Nagai, Ryuichiro Egashira, Mariko Takeuchi, Mai Nakano, Hitomi Saito, Misaki Moriguchi, Satoko Tonari, Satoshi Watanabe, Akimitsu Miyake and Kinya Ashida
Nutrients 2022, 14(6), 1199; https://doi.org/10.3390/nu14061199 - 12 Mar 2022
Cited by 6 | Viewed by 3776
Abstract
Ketogenic diets, which are carbohydrate-restricted high-fat diets, may have therapeutic effects on various diseases, including cancer. However, ketogenic diets are often not standardized and, therefore, results are difficult to interpret. We previously investigated the usefulness of ketogenic diets in cancer therapy, where ketogenic [...] Read more.
Ketogenic diets, which are carbohydrate-restricted high-fat diets, may have therapeutic effects on various diseases, including cancer. However, ketogenic diets are often not standardized and, therefore, results are difficult to interpret. We previously investigated the usefulness of ketogenic diets in cancer therapy, where ketogenic formulas (KF) were used as supplements to enhance blood ketone bodies; however, the amount of KF was determined empirically with reference to blood ketone bodies levels. Here, to determine a standardized optimal amount of KF, we investigated temporal changes in blood ketone bodies (acetoacetic acid (AcAc), β-hydroxybutyrate (BHB)) and safety in 20 healthy individuals when KF was taken repeatedly under the conditions of a ketogenic diet (UMIN000034216). The diurnal variation in total ketone bodies, and AcAc and BHB levels significantly increased after lunch and after dinner, on the 4th day of KF administration. There were no significant safety issues related to KF in the context of anthropometric, metabolic, nutritional, urological and gastrointestinal parameters. In addition, ketogenic diets lead to changes in gut microbiota. KF showed a decrease in phylum Firmicutes. Our study provides baseline data of the usefulness of KF in a ketogenic diet. Full article
(This article belongs to the Special Issue The Ketogenic Diet for Cancer)
►▼ Show Figures

Figure 1

Review

Jump to: Research, Other

17 pages, 1391 KiB  
Review
Molecular Mechanisms Underlying the Bioactive Properties of a Ketogenic Diet
by Mari Murakami and Paola Tognini
Nutrients 2022, 14(4), 782; https://doi.org/10.3390/nu14040782 - 13 Feb 2022
Cited by 17 | Viewed by 7601
Abstract
The consumption of a high-fat, low-carbohydrate diet (ketogenic diet) has diverse effects on health and is expected to have therapeutic value in neurological disorders, metabolic syndrome, and cancer. Recent studies have shown that a ketogenic diet not only pronouncedly shifts the cellular metabolism [...] Read more.
The consumption of a high-fat, low-carbohydrate diet (ketogenic diet) has diverse effects on health and is expected to have therapeutic value in neurological disorders, metabolic syndrome, and cancer. Recent studies have shown that a ketogenic diet not only pronouncedly shifts the cellular metabolism to pseudo-starvation, but also exerts a variety of physiological functions on various organs through metabolites that act as energy substrates, signaling molecules, and epigenetic modifiers. In this review, we highlight the latest findings on the molecular mechanisms of a ketogenic diet and speculate on the significance of these functions in the context of the epigenome and microbiome. Unraveling the molecular basis of the bioactive effects of a ketogenic diet should provide solid evidence for its clinical application in a variety of diseases including cancer. Full article
(This article belongs to the Special Issue The Ketogenic Diet for Cancer)
►▼ Show Figures

Figure 1

Other

Jump to: Research, Review

17 pages, 2177 KiB  
Systematic Review
Effects of the Ketogenic Diet in the Treatment of Gliomas: A Systematic Review
by Beatriz Sargaço, Patrícia Almeida Oliveira, Maria Luz Antunes and Ana Catarina Moreira
Nutrients 2022, 14(5), 1007; https://doi.org/10.3390/nu14051007 - 27 Feb 2022
Cited by 13 | Viewed by 4432
Abstract
The ketogenic diet (KD) is a restrictive therapeutic diet, distinguished by being hyperlipidic, normoproteic, and hypoglucidic. This diet simulates biochemical changes related to fasting periods to achieve systemic ketosis. The metabolic particularities of glioma tumors motivated the rise in investigations and nutritional strategies, [...] Read more.
The ketogenic diet (KD) is a restrictive therapeutic diet, distinguished by being hyperlipidic, normoproteic, and hypoglucidic. This diet simulates biochemical changes related to fasting periods to achieve systemic ketosis. The metabolic particularities of glioma tumors motivated the rise in investigations and nutritional strategies, such as KD, to modulate the glycemic response as a treatment. This systematic review followed the PRISMA recommendations and was published in PROSPERO, with the identification CRD42021264173. The databases used were EMBASE, PubMed/Medline, Scopus, and Web of Science, and the studies were analyzed using the web-based application Rayyan. To analyze the risk of bias, Cochrane RevMan 5 software was used. For the analysis and treatment of statistical data, Microsoft® Excel® was used. A total of nine original articles were included. Data on survival, symptomology, and quality of life were collected. Mean overall survival was 15.9 months. Constipation and fatigue were the most reported symptoms. In 44.4% of the studies, an improvement in the quality of life was found. The KD is supported by most published studies as an effective therapy in the treatment of malignant gliomas due to its positive effects on patient survival. It was not possible to conclude the effectiveness of KD on quality of life. Full article
(This article belongs to the Special Issue The Ketogenic Diet for Cancer)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop