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Nutrients
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The Role of Magnesium Status in Human Health
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The Role of Magnesium Status in Human Health

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Micronutrients and Human Health".

Deadline for manuscript submissions: 15 October 2025 | Viewed by 9152

Special Issue Editor

Dr. Andrea Rosanoff

E-Mail Website
Guest Editor
CMER—Center for Magnesium Education and Research, Pahoa, HI 96778, USA
Interests: nutritional minerals; magnesium; heart disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Magnesium, an essential nutrient, is involved in several crucial physiological, immunological, biochemical, cellular, and neurological processes. A low-magnesium status can have a major influence on the pathogenesis of several chronic diseases, including diabetes, cardiovascular disease, and their risk factors, as well as nervous system disorders such as depression. Magnesium intake is generally suboptimal in people consuming a diet constituted by highly processed foods and containing substantial levels of highly refined foods that are very low in magnesium. Such chronically sub-optimal magnesium diets have been associated with cardiovascular mortality, including ischemic heart disease and stroke, the top two causes of death globally. While low serum magnesium is used to assess hospitalized patients, a reliable marker of magnesium status in ambulatory patients, which could maximize the prevention of these chronic low-magnesium diseases, remains wanting. The following Special Issue aims to provide cutting-edge research, particularly original (epidemiological, clinical, and experimental) and review articles (including systematic reviews and meta-analyses), regarding the relationship between magnesium status (dietary and/or physiological) and human disease states, including (but not limited to) heart failure, coronary heart disease, and cardiovascular disease, and/or risk factors in different populations as well as novel models for assessing magnesium status in populations and individuals.

Dr. Andrea Rosanoff
Guest Editor

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Keywords

  • low-magnesium status
  • magnesium assessment
  • dietary magnesium
  • serum magnesium
  • heart disease
  • heart failure
  • coronary heart disease
  • cardiovascular
  • metabolic syndrome
  • mortality
  • CVD risk factors
  • immunological health
  • COVID
  • depression/emotional health

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Published Papers (2 papers)

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12 pages, 420 KiB  
Article
Clinical Guideline for Detection and Management of Magnesium Deficiency in Ambulatory Care
by Sherrie Colaneri-Day and Andrea Rosanoff
Nutrients 2025, 17(5), 887; https://doi.org/10.3390/nu17050887 - 28 Feb 2025
Viewed by 2245
Abstract
Background: Magnesium (Mg) deficiency is associated with many common chronic conditions and potentially severe health care outcomes, including cardiovascular disease, cardiovascular risk factors, and diabetes. However, Mg deficiency is underdiagnosed and often underrecognized in the ambulatory health care setting, and nutrition education and [...] Read more.
Background: Magnesium (Mg) deficiency is associated with many common chronic conditions and potentially severe health care outcomes, including cardiovascular disease, cardiovascular risk factors, and diabetes. However, Mg deficiency is underdiagnosed and often underrecognized in the ambulatory health care setting, and nutrition education and training are often limited for health care providers (HCPs). Methods: A clinical guideline for detecting and treating Mg deficiency in the ambulatory care setting was developed. A pilot study was conducted in which HCPs received education on Mg and completed pre-test and post-test questionnaires to assess the intervention efficacy of the guideline. Results: Ten HCPs participated in the pilot study via telephone or face-to-face session. In general, there was a statistically significant increase in Mg knowledge among HCPs, due to the intervention of presentation of the guideline, with a nonsignificant increase in clinical practice application. However, the 1-month follow-up survey results showed that HCPs were likely to incorporate Mg assessment and treatment tools from the guideline in their future practice. Conclusions: These findings suggest that the use of the proposed clinical guideline may increase HCP knowledge and improve the diagnosis and treatment of Mg deficiency. Further use, development, and evaluation of this guideline is warranted. Full article
(This article belongs to the Special Issue The Role of Magnesium Status in Human Health)
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Review

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12 pages, 267 KiB  
Review
The Role of Dietary Magnesium in Cardiovascular Disease
by Forrest H. Nielsen
Nutrients 2024, 16(23), 4223; https://doi.org/10.3390/nu16234223 - 6 Dec 2024
Cited by 2 | Viewed by 6348
Abstract
In the past 20 years, a large number of epidemiological studies, randomized controlled trials, and meta-analyses have found an inverse relationship between magnesium intake or serum magnesium and cardiovascular disease, indicating that low magnesium status is associated with hypertension, coronary artery calcification, stroke, [...] Read more.
In the past 20 years, a large number of epidemiological studies, randomized controlled trials, and meta-analyses have found an inverse relationship between magnesium intake or serum magnesium and cardiovascular disease, indicating that low magnesium status is associated with hypertension, coronary artery calcification, stroke, ischemic heart disease, atrial fibrillation, heart failure, and cardiac mortality. Controlled metabolic unit human depletion–repletion experiments found that a mild or moderate magnesium deficiency can cause physiological and metabolic changes that respond to magnesium supplementation, which indicates that these types of deficiencies or chronic latent magnesium deficiency are contributing factors to the occurrence and severity of cardiovascular disease. Mechanisms through which a mild or moderate magnesium deficiency can contribute to this risk include inflammatory stress, oxidative stress, dyslipidemia and deranged lipid metabolism, endothelial dysfunction, and dysregulation of cellular ion channels, transporters, and signaling. Based on USA official DRIs or on suggested modified DRIs based on body weight, a large number of individuals routinely consume less magnesium than the EAR. This especially occurs in populations that do not consume recommended amounts of whole grains, pulses, and green vegetables. Thus, inadequate magnesium status contributing to cardiovascular disease is widespread, making magnesium a nutrient of public health concern. Full article
(This article belongs to the Special Issue The Role of Magnesium Status in Human Health)
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