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Nutrients
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Dietary Protein and Energy Balance
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Dietary Protein and Energy Balance

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Proteins and Amino Acids".

Deadline for manuscript submissions: closed (25 March 2024) | Viewed by 17513

Special Issue Editors

Dr. Evasio Pasini

E-Mail Website
Guest Editor
1. Department of Clinical and Experimental Sciences, University of Brescia, 25100 Brescia, Italy
2. Italian Association of Functional Medicine, 20855 Lesmo, MB, Italy
Interests: metabolism; amino acid; sarcopenia; chronic diseases
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Giovanni Corsetti

E-Mail Website1 Website2
Guest Editor
Division of Human Anatomy and Physiopathology, Department of Clinical and Experimental Sciences, University of Brescia, 25023 Brescia, Italy
Interests: cell metabolism; amino acids; immunohistochemistry; electron microscopy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

It is well known that protein synthesis and energy production are essential for cell life. Indeed, many processes such as mitochondrial respiration, the availability of various metabolic substrates such as amino-acids, the stimulation of cellular metabolic enzyme regulators such as mTOR, and autophagy are dynamically interconnected and are involved in maintaining the balance between energy production and protein synthesis. In addition, it must be remembered that protein synthesis and cellular energy metabolism are also influenced by a close cross-talk between various organs or systems regulated by messenger molecules such as hormones, cytokines, and/or metabokines.

The aim of this Special Issue is to provide an update on dietary protein and energy balance as contributors to the maintenance of quality of life at different ages and in different physical conditions, including exercise training, in both healthy subjects or diseased patients.

Therefore, to contribute to this Special Issue, please feel free to submit review or original articles on the influence of diet, dietary supplements, weight changes, protein metabolism, etc., both in human and experimental models. This knowledge will help to improve support and prevention nutritional strategies for many physiological conditions and at different stages of life.

Dr. Evasio Pasini
Prof. Dr. Giovanni Corsetti
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • diet
  • proteins
  • amino acids
  • energy
  • metabokines
  • dietary supplements
  • metabolism
  • weight changes
  • human
  • experimental models

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Published Papers (3 papers)

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Review

15 pages, 995 KiB  
Review
Importance of Energy, Dietary Protein Sources, and Amino Acid Composition in the Regulation of Metabolism: An Indissoluble Dynamic Combination for Life
by Giovanni Corsetti, Evasio Pasini, Tiziano M. Scarabelli, Claudia Romano, Arashpreet Singh, Carol C. Scarabelli and Francesco S. Dioguardi
Nutrients 2024, 16(15), 2417; https://doi.org/10.3390/nu16152417 - 25 Jul 2024
Cited by 7 | Viewed by 7095
Abstract
Purpose. This paper aims to present a unique perspective that emphasizes the intricate interplay between energy, dietary proteins, and amino acid composition, underscoring their mutual dependence for health-related considerations. Energy and protein synthesis are fundamental to biological processes, crucial for the sustenance of [...] Read more.
Purpose. This paper aims to present a unique perspective that emphasizes the intricate interplay between energy, dietary proteins, and amino acid composition, underscoring their mutual dependence for health-related considerations. Energy and protein synthesis are fundamental to biological processes, crucial for the sustenance of life and the growth of organisms. Methods and Results. We explore the intricate relationship between energy metabolism, protein synthesis, regulatory mechanisms, protein sources, amino acid availability, and autophagy in order to elucidate how these elements collectively maintain cellular homeostasis. We underscore the vital role this dynamic interplay has in preserving cell life. Conclusions. A deeper understanding of the link between energy and protein synthesis is essential to comprehend fundamental cellular processes. This insight could have a wide-ranging impact in several medical fields, such as nutrition, metabolism, and disease management. Full article
(This article belongs to the Special Issue Dietary Protein and Energy Balance)
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15 pages, 2878 KiB  
Review
Protein Restriction in Metabolic Health: Lessons from Rodent Models
by Khuhee Na and Yoon Jung Park
Nutrients 2024, 16(2), 229; https://doi.org/10.3390/nu16020229 - 10 Jan 2024
Cited by 3 | Viewed by 3840
Abstract
Consumption of protein-rich diets and supplements has been increasingly advocated by individuals seeking to optimize metabolic health and mitigate the effects of aging. Protein intake is postulated to support muscle mass retention and enhance longevity, underscoring its perceived benefits in age-related metabolic regulation. [...] Read more.
Consumption of protein-rich diets and supplements has been increasingly advocated by individuals seeking to optimize metabolic health and mitigate the effects of aging. Protein intake is postulated to support muscle mass retention and enhance longevity, underscoring its perceived benefits in age-related metabolic regulation. However, emerging evidence presents a paradox; while moderate protein consumption contributes to health maintenance, an excessive intake is associated with an elevated risk of chronic diseases, notably obesity and diabetes. Furthermore, recent studies suggest that reducing the ratio of protein intake to macronutrients improves metabolic parameters and extends lifespan. The aim of this study is to review the current evidence concerning the metabolic effects of protein-restricted diets and their potential mechanisms. Utilizing rodent models, investigations have revealed that protein-restricted diets exert a notable influence over food intake and energy consumption, ultimately leading to body weight loss, depending on the degree of dietary protein restriction. These phenotypic alterations are primarily mediated by the FGF21 signaling pathway, whose activation is likely regulated by ATF4 and the circadian clock. The evidence suggests that protein-restricted diets as an alternative approach to calorie-restricted regimes, particularly in overweight or obese adults. However, more research is needed to determine the optimal level of restriction, duration, and long-term effects of such interventions. Full article
(This article belongs to the Special Issue Dietary Protein and Energy Balance)
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12 pages, 768 KiB  
Review
Impact of Dietary Protein on Osteoporosis Development
by Gabriela Kędzia, Martyna Woźniak, Włodzimierz Samborski and Bogna Grygiel-Górniak
Nutrients 2023, 15(21), 4581; https://doi.org/10.3390/nu15214581 - 28 Oct 2023
Cited by 9 | Viewed by 6064
Abstract
Osteoporosis is a frequent yet unsolved health problem among older people. The influence of dietary protein still raises many questions regarding its quality and quantity in the context of bone health. The aim of this manuscript is to review the latest evidence on [...] Read more.
Osteoporosis is a frequent yet unsolved health problem among older people. The influence of dietary protein still raises many questions regarding its quality and quantity in the context of bone health. The aim of this manuscript is to review the latest evidence on plant and animal protein influences on bone health in various groups of patients. The review is based on original studies, meta-analyses, randomized controlled trials, and prospective cohort studies published in PubMed and Cochrane databases during the last five years. Combining plant and animal protein with physical activity has the best effect on bones (muscle strengthening and reducing the risk of falls), while high protein intake can have adverse effects during bed rest. Despite the content of isoflavones, plant protein is not more beneficial than animal protein (dairy products) and can increase bone resorption markers. Hypoestrogenism due to menopause or eating disorders leads to low bone density and an increased risk of osteoporosis. A well-balanced diet with sufficient energy supply and protein intake (both of plant and animal origins) and adequate physical activity are crucial to ensure bone health. Dietary interventions should consider the quantity and quality of protein in patients with other comorbidities, particularly in an aging society. Full article
(This article belongs to the Special Issue Dietary Protein and Energy Balance)
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