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Nutrients
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Vitamins and Human Health: 3rd Edition
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Vitamins and Human Health: 3rd Edition

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Micronutrients and Human Health".

Deadline for manuscript submissions: 15 November 2025 | Viewed by 303

Special Issue Editor

Dr. Tyler Barker

E-Mail Website
Guest Editor
1. Sports Medicine Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA
2. Department of Orthopaedics, University of Utah, Salt Lake City, UT, USA
Interests: anterior cruciate ligament injury; osteoarthritis; cachexia; vitamin D; cytokines; systemic inflammation; precision nutrition
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Vitamins are essential compounds involved in fundamental functions of the body. Vitamins differ in physiological functions and are broadly classified as water-soluble or fat-soluble. The purpose of this Special Issue, “Vitamins and Human Health: 3rd Edition”, is to build upon previous editions by providing cutting-edge original research and review articles regarding the diverse properties of various vitamins in disease and healthy living conditions. This Special Issue will discuss the potential role of vitamins on health and disease etiology, progression, treatment, and the recovery from injury and/or surgery. Articles eloquently discussing the various or new determinants of endogenous vitamin levels in disease- and non-disease-related conditions are encouraged. Submissions discussing the influence of a vitamin or vitamins on physical performance and survival are also welcome.

Dr. Tyler Barker
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • vitamin A
  • vitamin B complex
  • vitamin C
  • vitamin D
  • vitamin E
  • vitamin K

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Published Papers (1 paper)

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Research

17 pages, 1524 KiB  
Article
Vitamin Status and Risk of Age-Related Diseases Among Adult Residents of the Pearl River Delta Region
by Yongze Zhao, Siqian Zheng, Bohan Wang, Wenhui Xiao, Ping He and Ying Bian
Nutrients 2025, 17(10), 1637; https://doi.org/10.3390/nu17101637 - 10 May 2025
Viewed by 218
Abstract
Background: The Pearl River Delta (PRD) region in Guangdong, China, is urbanized and economically significant. Rapid development has shaped diverse dietary habits. In this densely populated area, there is an urgent need to assess vitamin status and its impact on age-related diseases. [...] Read more.
Background: The Pearl River Delta (PRD) region in Guangdong, China, is urbanized and economically significant. Rapid development has shaped diverse dietary habits. In this densely populated area, there is an urgent need to assess vitamin status and its impact on age-related diseases. Methods: A total of 2646 participants (age: 50.92 ± 9.30 years; male: 64.06%) were recruited from the Pearl River Delta (PRD) region. Participants were included from 1 December 2020 to 30 November 2021. Three restricted cubic spline logistic models, interaction terms, and mediated effects analyses were used to assess the association between vitamin A, B, E, B1, B2, B3, B5, B6, and B9 between five age-related diseases: cerebrovascular disease (CVD), coronary heart disease (CHD), hypertension (HTN), dyslipidemia (DYS), and type 2 diabetes mellitus (T2DM). Results: Blood concentrations of nine vitamins showed a right-skewed distribution. Significant correlations were found between vitamin levels and age-related diseases across nine groups (p < 0.05). A J-shaped relationship was observed between vitamin levels and the risk of age-related diseases, except for the Vitamin A-HTN/T2DM, which showed Maximum Effective Concentration (MEC). Specific thresholds included: Vitamin A: 1080 ng/mL (DYS); Vitamin B1: 77 ng/mL (CVD), 75.5 ng/mL (HTN); Vitamin B5: 900 ng/mL (CVD), 600 ng/mL (HTN), 690 ng/mL (DYS); Vitamin B6: 82 ng/mL (CVD). The protective effect of vitamins against age-related diseases decreased with age, and higher levels of vitamins A and B1 correlated with increased hypertension risk in older adults (Pinteraction < 0.01). Low Body Resilience Index (BRI) and physical activity mediated the protective effects of vitamins A and B5 on HTN and DYS, while no mediating effects were found for smoking and alcohol consumption. Conclusions: The effectiveness of multivitamin supplementation in preventing cardiovascular, cerebrovascular, and metabolic diseases may be limited in healthy aging populations. Health professionals should consider patients’ physiological conditions and blood vitamin levels to avoid overdose. More interventional studies are needed to establish causal relationships. Full article
(This article belongs to the Special Issue Vitamins and Human Health: 3rd Edition)
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