E-Mail Alert

Add your e-mail address to receive forthcoming issues of this journal:

Journal Browser

Journal Browser

Special Issue "Nutrition, Cognition and Brain Integrity"

A special issue of Nutrients (ISSN 2072-6643).

Deadline for manuscript submissions: 1 October 2019

Special Issue Editor

Guest Editor
Prof. Dr. Panteleimon Giannakopoulos

Department of Psychiatry, Faculty of Medicine, University of Geneva, 1205 Genève, Switzerland
Website | E-Mail
Interests: Alzheimer’s disease; biomarkers; brain activation; magnetic resonance imaging; neurosciences; psychiatry

Special Issue Information

Dear Colleagues,

Lifetime multidomain interventions including nutritional programs appear to be cost-effective and safe strategies to mitigate cognitive decline in older adults. Antioxidant-rich foods (nuts, grapes, cherries) as well as unsaturated fatty acid, polyphenol and vitamin supplementation are thought to improve both biomarker status and cognitive-related outcomes in MCI and AD. Along the same line, the roles of adiposity and physical inactivity in the pathophysiology of the brain in middle life as well as the molecular mechanisms of senescence have attracted a growing interest in the scientific community. New data indicate the complexity and necessity of endogenous/dietary antioxidants for the control of neuron-glia signalling. Recent studies proposed that omega-3 and -6 fatty acids act as mediators for energy metabolism, neural plasticity and memory during aging. These lines of evidence open a highly promising field for future research linking nutrition and clinical neurosciences.

This Special Issue of Nutrients, entitled “Nutrition, Cognition and Brain Integrity”, welcomes the submission of manuscripts either describing original research or reviewing the relevant scientific literature, including systematic reviews and meta-analyses.

Prof. Dr. Panteleimon Giannakopoulos
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • brain activation
  • cell protection
  • antioxidant
  • neuronal plasticity
  • memory
  • antioxidants
  • faty acids
  • obesity

Published Papers (3 papers)

View options order results:
result details:
Displaying articles 1-3
Export citation of selected articles as:

Research

Jump to: Review

Open AccessArticle
Effect of Aruncus dioicus var. kamtschaticus Extract on Neurodegeneration Improvement: Ameliorating Role in Cognitive Disorder Caused by High-Fat Diet Induced Obesity
Nutrients 2019, 11(6), 1319; https://doi.org/10.3390/nu11061319
Received: 2 May 2019 / Revised: 4 June 2019 / Accepted: 11 June 2019 / Published: 12 June 2019
PDF Full-text (2130 KB) | Supplementary Files
Abstract
This study was performed to estimate the possibility of using an ethyl acetate fraction from Aruncus dioicus var. kamtschaticus (EFAD) on metabolic syndrome that is induced by a high-fat diet (HFD). It was demonstrated that EFAD suppresses lipid accumulation and improves insulin resistance [...] Read more.
This study was performed to estimate the possibility of using an ethyl acetate fraction from Aruncus dioicus var. kamtschaticus (EFAD) on metabolic syndrome that is induced by a high-fat diet (HFD). It was demonstrated that EFAD suppresses lipid accumulation and improves insulin resistance (IR) caused by Tumor necrosis factor alpha (TNF-α) in in-vitro experiments using the 3T3-L1 cell. In in-vivo tests, C57BL/6 mice were fed EFAD at 20 and 40 mg/kg body weight (BW) for four weeks after the mice were fed HFD for 15 weeks to induce obesity. EFAD significantly suppressed the elevation of BW and improved impaired glucose tolerance in obese mice. Additionally, this study showed that EFAD has an ameliorating effect on obesity-induced cognitive disorder with behavioral tests. The effect of EFAD on peripheral-IR improvement was confirmed by serum analysis and western blotting in peripheral tissues. Additionally, EFAD showed an ameliorating effect on HFD-induced oxidative stress, impaired cholinergic system and mitochondrial dysfunction, which are interrelated symptoms of neurodegeneration, such as Alzheimer’s disease and central nervous system (CNS)-IR in brain tissue. Furthermore, we confirmed that EFAD improves CNS-IR by confirming the IR-related factors in brain tissue. Consequently, this study suggests the possibility of using EFAD for the prevention of neurodegeneration by improving metabolic syndrome that is caused by HFD. Full article
(This article belongs to the Special Issue Nutrition, Cognition and Brain Integrity)
Figures

Graphical abstract

Open AccessArticle
Hesperidin Alleviates Methotrexate-Induced Memory Deficits via Hippocampal Neurogenesis in Adult Rats
Nutrients 2019, 11(4), 936; https://doi.org/10.3390/nu11040936
Received: 27 March 2019 / Revised: 18 April 2019 / Accepted: 22 April 2019 / Published: 25 April 2019
PDF Full-text (6188 KB) | HTML Full-text | XML Full-text
Abstract
Methotrexate (MTX), a folic acid antagonist, is widely used in cancer treatment. However, treatment with MTX reduces hippocampal neurogenesis, leading to memory deficits. Hesperidin (Hsd) is a flavonoid glycoside that promotes anti-inflammation, acts as an antioxidant, and has neuroprotective properties. Consumption of Hsd [...] Read more.
Methotrexate (MTX), a folic acid antagonist, is widely used in cancer treatment. However, treatment with MTX reduces hippocampal neurogenesis, leading to memory deficits. Hesperidin (Hsd) is a flavonoid glycoside that promotes anti-inflammation, acts as an antioxidant, and has neuroprotective properties. Consumption of Hsd enhances learning and memory. In the present study, we investigated the protective effects of Hsd against MTX-induced impairments of memory and neurogenesis; male Sprague Dawley rats were administered with a single dose of MTX (75 mg/kg) by intravenous (i.v.) injection on days 8 and 15 or Hsd (100 mg/kg) by oral gavage for 21 days. Memory was tested using novel object location (NOL) and novel object recognition (NOR) tasks. Immunofluorescence staining of Ki-67, bromodeoxyuridine (BrdU), and doublecortin (DCX) was performed to assess cell proliferation, survival, and immature neurons. The data showed that Hsd and MTX did not disable locomotor ability. The MTX animals exhibited memory deficits in both memory tests. There were significant decreases in the numbers of cell proliferation, survival, and immature neurons in the MTX animals. However, co-administration with MTX and Hsd alleviated memory loss and neurogenesis decline. These results revealed that Hsd could protect against MTX side effects in the animals in this study. Full article
(This article belongs to the Special Issue Nutrition, Cognition and Brain Integrity)
Figures

Graphical abstract

Review

Jump to: Research

Open AccessReview
Natural Antioxidant Anthocyanins—A Hidden Therapeutic Candidate in Metabolic Disorders with Major Focus in Neurodegeneration
Nutrients 2019, 11(6), 1195; https://doi.org/10.3390/nu11061195
Received: 7 May 2019 / Revised: 23 May 2019 / Accepted: 24 May 2019 / Published: 28 May 2019
Cited by 1 | PDF Full-text (1727 KB)
Abstract
All over the world, metabolic syndrome constitutes severe health problems. Multiple factors have been reported in the pathogenesis of metabolic syndrome. Metabolic disorders result in reactive oxygen species (ROS) induced oxidative stress, playing a vital role in the development and pathogenesis of major [...] Read more.
All over the world, metabolic syndrome constitutes severe health problems. Multiple factors have been reported in the pathogenesis of metabolic syndrome. Metabolic disorders result in reactive oxygen species (ROS) induced oxidative stress, playing a vital role in the development and pathogenesis of major health issues, including neurological disorders Alzheimer’s disease (AD) Parkinson's disease (PD). Considerable increasing evidence indicates the substantial contribution of ROS-induced oxidative stress in neurodegenerative diseases. An imbalanced metabolism results in a defective antioxidant defense system, free radicals causing inflammation, cellular apoptosis, and tissue damage. Due to the annual increase in financial and social burdens, in addition to the adverse effects associated with available synthetic agents, treatment diversion from synthetic to natural approaches has occurred. Antioxidants are now being considered as convincing therapeutic agents against various neurodegenerative disorders. Therefore, medicinal herbs and fruits currently receive substantially more attention as commercial sources of antioxidants. In this review, we argue that ROS-targeted therapeutic interventions with naturally occurring antioxidant flavonoid, anthocyanin, and anthocyanin-loaded nanoparticles might be the ultimate treatment against devastating illnesses. Furthermore, we elucidate the hidden potential of the neuroprotective role of anthocyanins and anthocyanin-loaded nanoparticles in AD and PD neuropathies, which lack sufficient attention compared with other polyphenols, despite their strong antioxidant potential. Moreover, we address the need for future research studies of native anthocyanins and nano-based-anthocyanins, which will be helpful in developing anthocyanin treatments as therapeutic mitochondrial antioxidant drug-like regimens to delay or prevent the progression of neurodegenerative diseases, such as AD and PD. Full article
(This article belongs to the Special Issue Nutrition, Cognition and Brain Integrity)
Figures

Graphical abstract

Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top