Special Issue "Neonatal Short Bowel Syndrome: Nutritional Management and Research Directions"

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".

Deadline for manuscript submissions: 30 November 2020.

Special Issue Editor

Dr. Paola Roggero
Guest Editor
Head Neonatal Nutrition Center; Department of Clinical Sciences and Community Health, University of Milan, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Italy
Interests: preterm infants; nutrition in infancy; body composition; donor milk; human breast milk; intestinal failure; artificial nutrition in infancy
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Special Issue Information

Dear Colleagues,

Neonatal short bowel syndrome is a clinical condition that necessitates parenteral nutrition in order to sustain growth and development. It is the most common cause of intestinal failure in infants, and its incidence and prevalence are increasing.

Short bowel syndrome in neonatal intensive care unit patients can result from various conditions, particularly intestinal atresia, gastroschisis, necrotizing enterocolitis, and intestinal volvulus. Subsequently, in the acute post-surgical period, functional changes in nutrient absorption and motility take place in the residual gastrointestinal tract.

Even if the residual intestinal length has been correlated with adaptation and survival, the neonatal care improvement, the development of new strategies on parenteral nutrition, the prevention of intravenous infections, and surgical procedures have significantly increased the survival of infants with short bowel syndrome. Therefore, the prognosis of short bowel syndrome has been improving with advances in multidisciplinary intestinal care.

The majority of infants with short bowel syndrome can reach normal growth and development by means of an adequate nutritional strategy and a multidisciplinary approach.

The nutritional research directions on infants with short bowel syndrome have to limit the following clinical problems:

  • Food avoidance
  • Long term nutritional deficiency
  • Micronutrients deficiency
  • PN-liver failure

Dr. Paola Roggero
Guest Editor

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  • Short bowel syndrome
  • Parenteral nutrition
  • Home parenteral nutrition
  • Neonate
  • PN-liver failure
  • Micronutrients deficiency
  • Long term nutritional deficiency

Published Papers (1 paper)

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Open AccessReview
To Wean or Not to Wean: The Role of Autologous Reconstructive Surgery in the Natural History of Pediatric Short Bowel Syndrome on Behalf of Italian Society for Gastroenterology, Hepatology and Nutrition (SIGENP)
Nutrients 2020, 12(7), 2136; https://doi.org/10.3390/nu12072136 - 18 Jul 2020
Pediatric Short Bowel Syndrome (SBS) can require prolonged parenteral nutrition (PN). Over the years, SBS management has been implemented by autologous gastrointestinal reconstructive surgery (AGIR). The primary objective of the present review was to assess the effect of AGIR on weaning off PN. [...] Read more.
Pediatric Short Bowel Syndrome (SBS) can require prolonged parenteral nutrition (PN). Over the years, SBS management has been implemented by autologous gastrointestinal reconstructive surgery (AGIR). The primary objective of the present review was to assess the effect of AGIR on weaning off PN. We also evaluated how AGIR impacts survival, the need for transplantation (Tx) and the development of liver disease (LD). We conducted a systematic literature search to identify studies published from January 1999 to the present and 947 patients were identified. PN alone was weakly associated with higher probability of weaning from PN (OR = 1.1, p = 0.03) and of surviving (OR = 1.05, p = 0.01). Adjusting for age, the probability of weaning off PN but of not surviving remained significantly associated with PN alone (OR = 1.08, p = 0.03). Finally, adjusting for age and primary diagnosis (gastroschisis), any association was lost. The prevalence of TX and LD did not differ by groups. In conclusion, in view of the low benefit in terms of intestinal adaptation and of the not negligible rate of complications (20%), a careful selection of candidates for AGIR should be required. Bowel dilation associated with failure of advancing EN and poor growth, should be criteria to refer for AGIR. Full article
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