Nutritional Strategies for Sarcopenia and Frailty in Chronic Liver Disease: From Assessment to Intervention
A Special Issue of Nutrients (ISSN 2072-6643) belonging to the section "Clinical Nutrition".
Deadline for manuscript submissions: 25 May 2027 | Viewed by 66
Editors
Interests: autoimmune liver disease; liver transplantation; end-stage liver disease; nutrition and body composition
Special Issues, Collections and Topics in MDPI journals
Interests: Malnutrition; Clinical Nutrition; Nutrition Support; Nutritional Biochemistry; Intestinal Failure; Oropharyngeal dysphagia
Interests: perioperative nutrition; clinical nutrition; malnutrition; sarcopenia; nutrition support; body composition; clinical research
Special Issue Information
Dear Colleagues,
Sarcopenia and physical frailty are distinct yet overlapping conditions that frequently affect patients with chronic liver disease (CLD). Both have been shown to independently predict adverse clinical outcomes, including hepatic decompensation, unplanned hospitalizations, and increased waitlist and post-transplant mortality. Importantly, sarcopenia and physical frailty also have a substantial negative impact on quality of life in patients with CLD.
Significant progress has been made in the recognition and assessment of these complications. There has been a shift from conventional nutritional markers, which are often confounded by ascites and impaired hepatic synthetic function, toward practical functional assessments such as the Liver Frailty Index and handgrip strength, complemented by cross-sectional imaging techniques, including CT- and MRI-derived measures of body composition. In parallel, contemporary nutritional management emphasizes adequate protein and energy intake, avoidance of prolonged fasting, and individualized aerobic and resistance exercise programs.
Despite these advances, the implementation of these strategies in clinical practice remains challenging because of heterogeneity in assessment methods and the lack of standardized, multidisciplinary pathways for prevention and intervention.
The objective of this Special Issue of Nutrients is to bring together contributions from researchers and clinicians across multiple disciplines to advance our understanding of the timely detection, prevention, and management of sarcopenia and physical frailty in CLD, while highlighting current knowledge gaps and priorities for future research. We welcome original research and review articles addressing nutrition screening and assessment, the metabolic mechanisms underlying muscle wasting, targeted dietary interventions and supplementation, and multidisciplinary strategies to prevent and mitigate sarcopenia and physical frailty in patients with CLD.
Dr. Aldo J. Montano-Loza
Dr. Aurora Serralde-Zúñiga
Guest Editors
Fernando Estrada-Moya
Guest Editor Assistant
Manuscript Submission Information
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Keywords
- chronic liver disease
- liver cirrhosis
- sarcopenia
- frailty assessment
- body composition
- nutritional assessment
- dietary interventions
- late-evening snack
- branched-chain amino acids (BCAAs)
- liver frailty index
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