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The Role of Phytochemicals in Cardiovascular Disease Prevention and Treatment

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: 5 October 2026 | Viewed by 630

Special Issue Editor


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Guest Editor
Division of Medicine, University College London, London, UK
Interests: cardiovascular functions in health (including exercise) and disease

Special Issue Information

Dear Colleagues,

This Special Issue will focus on the role that plant-derived chemical compounds such as Polyphenols, Carotenoids, Glucosinolates, Flavonoids, Alkaloids, Isoflavones, Beta-carotene, Phytosterols, Anthocyanidins, Catechins, Terpenoids, etc., could play in cardiovascular disease prevention and treatment. Although they are generally not considered essential nutrients for human health, they have potential benefits through their antioxidant, anti-inflammatory, and immune-boosting properties. This Special Issue will specifically focus on harnessing these compounds for the prevention and treatment of heart and circulatory diseases. This issue will cover their modes of action, efficacy, and any trials on their use in the prevention or treatment of cardiovascular diseases. Studies with animal or human models of cardiovascular diseases, as well as mechanistic studies with cells and tissues that demonstrate potential, are welcome for submission.

Dr. Nelson N. Orie
Guest Editor

Manuscript Submission Information

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Keywords

  • phytochemicals
  • cardiovascular disease
  • prevention
  • treatment
  • mode of actions
  • antioxidant
  • anti-inflammatory
  • cardioprotection
  • vascular protection
  • antithrombotic
  • bioactives
  • phytonutrients

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Published Papers (1 paper)

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Review

18 pages, 935 KB  
Review
Modulation of Redox Balance by Phytochemicals: Implications for Cardiovascular Health
by Morana Jaganjac and Nelson N. Orie
Nutrients 2026, 18(8), 1204; https://doi.org/10.3390/nu18081204 - 10 Apr 2026
Viewed by 304
Abstract
Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide, with oxidative stress playing a major role in disease pathogenesis by promoting endothelial dysfunction, vascular inflammation, and tissue damage. Oxidative stress results from an imbalance between antioxidant defenses and reactive oxygen species (ROS) [...] Read more.
Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide, with oxidative stress playing a major role in disease pathogenesis by promoting endothelial dysfunction, vascular inflammation, and tissue damage. Oxidative stress results from an imbalance between antioxidant defenses and reactive oxygen species (ROS) in favor of ROS. Excessive ROS damage macromolecules and may trigger a chain reaction of lipid peroxidation, protein modification, and DNA damage. Phytochemicals are naturally occurring compounds in fruits and vegetables that may modulate redox homeostasis and positively impact cardiovascular health. The flavonoid Quercetin, Resveratrol, Curcuminoids, Coenzyme Q10, Hydroxysafflor yellow A, and Vitamins C and E have shown promise in human studies for improving endothelial function, lipid profile and markers of oxidative stress and inflammation. Among the key mechanisms of protection are their antioxidant role, anti-inflammatory role or modulation of nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, all of which contribute to cardiovascular protection. However, there are challenges associated with their use for health, such as the complexity of their quality and quantity, which require standardization, as well as their mechanisms of effects. Moreover, their systemic availability and bioactivity largely depend on metabolic transformation by the host gut microbiota. This review analyzed relevant publications in PubMed, Scopus, and Web of Science, up to February 2026, and summarizes current knowledge on phyto–chemical-mediated modulation of oxidative stress and its implications for cardiovascular protection in humans. The evidence suggests that phytochemicals hold promise for CVD prevention and treatment, but more work is needed to achieve standardization in quality and quantity. Full article
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