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New Advances in Anti-inflammatory Natural Products and Derivatives in Gastric and Colorectal Cancer Therapy

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A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: closed (25 March 2024) | Viewed by 2227

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Special Issue Information

Dear Colleagues,

Inflammation is related to the development of cancer. Chronic inflammation has been associated with cancer and tumorigenesis such as survival, tumor promotion, proliferation, resistance, invasion, cellular transformation, metastasis, and angiogenesis. Inflammation-mediated cancer can be caused by various mutation types that lead to the multifunction of tumor suppressors or oncogenes. Moreover, it results in the secretion of pro-inflammatory cytokines and chemokines by immune or cancer cells.

Recently, it has been shown that natural products and their derivatives have potential roles in the development of new drugs and pharmaceutical strategy against cancer, immune disease, and chronic inflammation, etc. Many studies have reported anti-cancer and anti-inflammatory natural products including polysaccharides, saponins, capsaicin, polyphenols, terpenoids, etc., and they have potential immunomodulatory effects in cancer and inflammatory disease. The immunoregulation mechanisms of natural products and their derivatives are involved in a diverse signal transduction pathway against cancer and inflammatory diseases. However, there is still a considerable obstacle in treating natural products and their derivatives as novel therapeutic strategies.

This Special Issue of Nutrients entitled “New Advances in Anti-inflammatory Natural Products and Derivatives in Gastric and Colorectal Cancer Therapy” will focus on new advances in therapeutic strategies to overcome inflammation and cancer using natural products and active compounds in various immune or cancer models. Therefore, we will present progress in the understanding of various signal transduction pathways and focus on therapeutic approaches to develop new treatments to overcome inflammation and cancer.

Dr. Tae Woo Kim
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

ER stress
apoptosis
cell death
natural products
inflammation
tumor microenvironment
cancer
radiation

Published Papers (2 papers)

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Research

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19 pages, 2743 KiB

Open AccessArticle

Paeoniflorin Induces ER Stress-Mediated Apoptotic Cell Death by Generating Nox4-Derived ROS under Radiation in Gastric Cancer

by Tae Woo Kim

Nutrients 2023, 15(24), 5092; https://doi.org/10.3390/nu15245092 - 13 Dec 2023

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Abstract

Gastric cancer is one of the most prevalent cancer types worldwide, and its resistance to cancer therapies, such as chemotherapy and radiotherapy, has made treating it a major challenge. Paeoniflorin (PF) is one potential pharmacological treatment derived from paeony root. However, in cancer, the molecular mechanisms and biological functions of PF are still unclear. In the present study, we found that PF exerts anti-tumor effects in vivo and in vitro and induces apoptotic cell death through ER stress, calcium (Ca²⁺), and reactive oxygen species (ROS) release in gastric cancer cells. However, ROS inhibition by DPI and NAC blocks cell death and the PERK signaling pathway via the reduction of Nox4. Moreover, PF triggers a synergistic inhibitory effect of the epithelial-mesenchymal transition (EMT) process under radiation exposure in radiation-resistant gastric cancer cells. These findings indicate that PF-induced Ca²⁺ and ROS release overcomes radioresistance via ER stress and induces cell death under radiation in gastric cancer cells. Therefore, PF, in combination with radiation, may be a powerful strategy for gastric cancer therapy. Full article

(This article belongs to the Special Issue New Advances in Anti-inflammatory Natural Products and Derivatives in Gastric and Colorectal Cancer Therapy)

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Review

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14 pages, 809 KiB

Open AccessReview

Treatment of Cachexia in Gastric Cancer: Exploring the Use of Anti-Inflammatory Natural Products and Their Derivatives

by Jerocin Vishani Loyala, Billy Down, Enoch Wong and Benjamin Tan

Nutrients 2024, 16(8), 1246; https://doi.org/10.3390/nu16081246 - 22 Apr 2024

Viewed by 806

Abstract

(1) Background: Gastric cancer is a significant cause of cancer-related mortality worldwide. Weight loss and malnutrition associated with cancer are linked with increased mortality rates and reduced quality of life. Cancer cachexia, characterised by the loss of skeletal muscle, is associated with approximately 20% of cancer-related deaths and differs from malnutrition in that it cannot be fully reversed by nutritional support alone. It is now recognised that the primary pathophysiological process underlying cancer cachexia is chronic inflammation leading to increased calorie consumption. Current treatments that focus on nutritional supplementation, psychological counselling, appetite stimulation and reducing inflammation are lacking in efficacy. This review focuses on the evidence supporting the potential roles of natural anti-inflammatory products and their derivatives including fatty acids, probiotics, amino acids, curcumin, fucoidan, epigallocatechin-3-gallate, ginger, resveratrol and Boswellia serrata in the management of gastric cancer cachexia. (2) Results: While natural anti-inflammatory products show promise in a number of in vitro and in vivo studies, there are only a small number of human studies available. Where present, the evidence base is heterogeneous, with varying study methodologies and outcomes. (3) Conclusions: Natural anti-inflammatory products represent a potential adjunctive therapy for gastric cancer cachexia. Further research, particularly well-designed clinical trials, is needed to elucidate their optimal role, dosing and safety profiles in the management of gastric cancer cachexia. Full article

(This article belongs to the Special Issue New Advances in Anti-inflammatory Natural Products and Derivatives in Gastric and Colorectal Cancer Therapy)

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