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Effects of Natural Bioactives on Pain and Neuroinflammation

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: closed (25 August 2024) | Viewed by 1613

Special Issue Editor


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Guest Editor
Department of Pharmacological and Biomolecular Sciences, University of Milan, 20133 Milan, Italy
Interests: pain; glial cells; neuroinflammation; neurodegenerative disorders; polyphenols; gut–brain axis; nutraceuticals

Special Issue Information

Dear Colleagues,

Neuroinflammation is an inflammatory response which takes place in the brain or spinal cord. This process is mediated by the production of cytokines, chemokines, reactive oxygen species and secondary messengers produced by resident CNS glia (microglia and astrocytes), endothelial cells, and peripherally derived immune cells. Neuroinflammation is involved in multiple pathological conditions, including pain and its transition from the acute to chronic form. Classic analgesics often fail to control pain in these patients, requiring the use of other drugs with severe side effects. Therefore, new approaches based on the administration of natural bioactives could represent a winning strategy.

The aim of this Special Issue is to collect the latest research on these topics. Therefore, original studies, narrative and systematic reviews, and meta-analyses that focus on the role of natural bioactive compounds in pain syndromes and neuroinflammation are most welcome.

Dr. Giulia Magni
Guest Editor

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Keywords

  • chronic pain
  • neuroinflammation
  • nutraceuticals
  • functional foods
  • analgesics
  • glial cells
  • cytokines

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Published Papers (1 paper)

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Research

18 pages, 4636 KiB  
Article
Exploring the Role of Bergamot Polyphenols in Alleviating Morphine-Induced Hyperalgesia and Tolerance through Modulation of Mitochondrial SIRT3
by Sara Ilari, Saverio Nucera, Lucia Carmela Passacatini, Federica Scarano, Roberta Macrì, Rosamaria Caminiti, Stefano Ruga, Maria Serra, Luigino Antonio Giancotti, Filomena Lauro, Concetta Dagostino, Valeria Mazza, Giovanna Ritorto, Francesca Oppedisano, Jessica Maiuolo, Ernesto Palma, Valentina Malafoglia, Carlo Tomino, Vincenzo Mollace and Carolina Muscoli
Nutrients 2024, 16(16), 2620; https://doi.org/10.3390/nu16162620 - 9 Aug 2024
Viewed by 1241
Abstract
Morphine is an important pain reliever employed in pain management, its extended utilize is hindered by the onset of analgesic tolerance and oxidative stress. Long-term morphine administration causes elevated production of reactive oxygen species (ROS), disrupting mitochondrial function and inducing oxidation. Sirtuin 3 [...] Read more.
Morphine is an important pain reliever employed in pain management, its extended utilize is hindered by the onset of analgesic tolerance and oxidative stress. Long-term morphine administration causes elevated production of reactive oxygen species (ROS), disrupting mitochondrial function and inducing oxidation. Sirtuin 3 (SIRT3), a mitochondrial protein, is essential in modulating ROS levels by regulating mitochondrial antioxidant enzymes as manganese superoxide dismutase (MnSOD). Our investigation focused on the impact of SIRT3 on hyperalgesia and morphine tolerance in mice, as evaluating the antioxidant effect of the polyphenolic fraction of bergamot (BPF). Mice were administered morphine twice daily for four consecutive days (20 mg/kg). On the fifth day, mice received an acute dose of morphine (3 mg/kg), either alone or in conjunction with BPF or Mn (III)tetrakis (4-benzoic acid) porphyrin (MnTBAP). We evaluated levels of malondialdehyde (MDA), nitration, and the activity of SIRT3, MnSOD, glutamine synthetase (GS), and glutamate 1 transporter (GLT1) in the spinal cord. Our findings demonstrate that administering repeated doses of morphine led to the development of antinociceptive tolerance in mice, accompanied by increased superoxide production, nitration, and inactivation of mitochondrial SIRT3, MnSOD, GS, and GLT1. The combined administration of morphine with either BPF or MnTBAP prevented these effects. Full article
(This article belongs to the Special Issue Effects of Natural Bioactives on Pain and Neuroinflammation)
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