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Nutrients
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Dietetic Management in MASLD (Evidence-Based Therapeutic Strategies)
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Dietetic Management in MASLD (Evidence-Based Therapeutic Strategies)

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".

Deadline for manuscript submissions: 25 September 2026 | Viewed by 427

Special Issue Editors

Dr. Emilia Papakonstantinou

E-Mail Website
Guest Editor
Laboratory of Dietetics and Quality of Life, Department of Food Science and Human Nutrition, Agricultural University of Athens, 11855 Athens, Greece
Interests: nutrition & metabolism; chrononutrition; clinical nutrition; obesity
Special Issues, Collections and Topics in MDPI journals
Dr. Matina Kouvari

E-Mail Website
Guest Editor
1. School of Health Science and Education, Department of Nutrition-Dietetics, Harokopio University, 17671 Athens, Greece
2. Faculty of Health, University of Canberra, Ngunnawal Land 2617, Australia
Interests: nutrition & cardiometabolic disorders; liver disease; human metabolism; nutrition epidemiology

Special Issue Information

Dear Colleagues,

Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as the hepatic manifestation of metabolic syndrome and represents one of the most prevalent chronic liver conditions worldwide. Closely linked to obesity, insulin resistance, type 2 diabetes, dyslipidemia, and systemic inflammation, MASLD reflects complex interactions between dietary habits, metabolic pathways, and genetic and environmental factors. This Special Issue aims to explore how dietary patterns and specific nutritional components contribute to the development, progression, and potential reversal of MASLD within the broader context of metabolic syndrome.

The collection invites original research articles, reviews, systematic reviews, and meta-analyses that examine the role of excess caloric intake, refined carbohydrates, saturated fats, and ultra-processed foods in promoting hepatic fat accumulation, lipotoxicity, and chronic low-grade inflammation. The collection also invites scientific manuscripts on protective dietary approaches—including Mediterranean-style diets, plant-based nutrition, and nutrient-dense eating patterns—emphasizing the beneficial effects of fiber, polyphenols, unsaturated fatty acids, and antioxidant-rich foods on metabolic regulation and liver health. Particular attention will be given to scientific papers that focus on the mechanisms linking diet to insulin signaling, gut microbiota modulation, oxidative stress, and hepatic lipid metabolism, as well as on emerging nutritional strategies for prevention and management, such as personalized nutrition, time-restricted eating, and dietary interventions combined with lifestyle modification.

Dr. Emilia Papakonstantinou
Dr. Matina Kouvari
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nutrition and metabolism
  • liver steatosis
  • liver fibrosis
  • metabolic syndrome
  • dietary patterns
  • personalized nutrition

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Published Papers (1 paper)

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Research

25 pages, 2320 KB  
Article
A Descriptive Analysis of Mediterranean Diet Meal Plans Using the Dietary Inflammatory Index, Dietary Antioxidant Index, and Dietary Lipid Indices: Implications for Dietary Intervention for Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Research
by Melvin Bernardino, Claudio Tiribelli and Natalia Rosso
Nutrients 2026, 18(8), 1281; https://doi.org/10.3390/nu18081281 - 17 Apr 2026
Viewed by 227
Abstract
Background/Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common chronic liver disorder linked to obesity, insulin resistance, and dyslipidemia. Nutrition plays a central role in modulating hepatic lipid metabolism, oxidative stress, and inflammation, yet practical, evidence-based dietary strategies remain limited. This [...] Read more.
Background/Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common chronic liver disorder linked to obesity, insulin resistance, and dyslipidemia. Nutrition plays a central role in modulating hepatic lipid metabolism, oxidative stress, and inflammation, yet practical, evidence-based dietary strategies remain limited. This study aimed to develop Mediterranean diet-based meal plans with varying macronutrient compositions and to characterize their nutritional profiles, as well as to evaluate them using established nutritional indices and diet score calculations, such as the Dietary Inflammatory Index, Dietary Antioxidant Index, and dietary lipid indices. Methods: Clinical practice guidelines (CPGs) from various academic and professional organizations were reviewed to assess current non-pharmacological treatments for MASLD, with a focus on determining whether the Mediterranean diet is the most recommended dietary pattern. Traditional, low-carbohydrate, and low-fat MedDiet patterns were translated into food-based meal plans. A 7-day meal plan was developed and analyzed for nutrient composition, then evaluated using the Dietary Inflammatory Index (DII), Dietary Antioxidant Index (DAI), Dietary Lipophilic Index (DLI), and Dietary Lipophilic Load (DLL). A Western diet (WD) that is characterized by ultra-processed food (UPF) was included as a comparative reference. Results: The validated dietary score calculations showed that all MedDiet patterns demonstrated consistently low DII scores (−2.00 to −2.81) and high DAI scores (3 to 20.03), whereas the WD showed high DII scores (5.0 to 6.09) and low DAI scores (−12.47 to −17.99). Despite these variations in macronutrients, the menu developed in the study on three MedDiet patterns showed negative DII and positive DAI scores. When comparing the traditional MedDiet with the WD, which have similar macronutrient distributions, the WD was characterized by less favorable DII and DAI scores. Conclusions: This study provides a descriptive, guideline-informed framework for Mediterranean diet-based meal plans with varying macronutrient compositions. Utilizing DII, DAI, DLI, and DLL offers a potential framework for designing dietary interventions. Further validation through clinical studies is needed to justify the potential for practical and digital translation. Nevertheless, the study provides initial insights that may inform future research on nutritional approaches for MASLD integrating dietary indices. Full article
(This article belongs to the Special Issue Dietetic Management in MASLD (Evidence-Based Therapeutic Strategies))
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