Exploring the Nutrient Sensing Mechanisms and Metabolic Regulatory Networks of Metabolic Diseases
A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".
Deadline for manuscript submissions: 25 February 2026 | Viewed by 22
Special Issue Editor
Special Issue Information
Dear Colleagues,
Accurate sensing of a surplus or deficit of energy is critical for metabolic health and elicits compensatory responses that promote homeostasis of both circulating and stored fuel. However, an individual’s ability to adapt to changes in the systemic energy level is affected in the presence of metabolic disease. Deficits in central and peripheral detection of nutrient state signals dysregulate long-term fuel storage and availability, but the mechanisms underlying this dysregulation require further exploration.
In this Special Issue, we welcome contributions that evaluate central and peripheral mechanisms of nutrient sensing and the downstream networks that mediate responses to dynamic energetic demands, both on cellular and systemic levels. Original research articles and focused reviews investigating the detection of nutrients or nutrient-responsive signals, the impact of these nutrient-sensing mechanisms on human health, and the consequence of their dysfunction in metabolic disease are encouraged.
Dr. Caroline Geisler
Guest Editor
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Keywords
- glucose
- lipids
- ketones
- bile acids
- nutrient state
- energy balance
- metabolic disease
- fuel homeostasis
- obesity
- fasting
- liver
- vagal nerve
- brain–body/body–brain communication
- hypothalamus
- dorsal vagal complex
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