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Exploring the Nutrient Sensing Mechanisms and Metabolic Regulatory Networks of Metabolic Diseases

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: 25 February 2026 | Viewed by 2

Special Issue Editor


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Guest Editor
Department of Pharmaceutical Sciences, University of Kentucky, Lexington, KY, USA
Interests: metabolic disease; glial physiology; glucose sensing; endozepines; type 2 diabetes; neuroscience; circumventricular organs; vagal communication

Special Issue Information

Dear Colleagues,

Accurate sensing of a surplus or deficit of energy is critical for metabolic health and elicits compensatory responses that promote homeostasis of both circulating and stored fuel. However, an individual’s ability to adapt to changes in the systemic energy level is affected in the presence of metabolic disease. Deficits in central and peripheral detection of nutrient state signals dysregulate long-term fuel storage and availability, but the mechanisms underlying this dysregulation require further exploration.

In this Special Issue, we welcome contributions that evaluate central and peripheral mechanisms of nutrient sensing and the downstream networks that mediate responses to dynamic energetic demands, both on cellular and systemic levels. Original research articles and focused reviews investigating the detection of nutrients or nutrient-responsive signals, the impact of these nutrient-sensing mechanisms on human health, and the consequence of their dysfunction in metabolic disease are encouraged. 

Dr. Caroline Geisler
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • glucose
  • lipids
  • ketones
  • bile acids
  • nutrient state
  • energy balance
  • metabolic disease
  • fuel homeostasis
  • obesity
  • fasting
  • liver
  • vagal nerve
  • brain–body/body–brain communication
  • hypothalamus
  • dorsal vagal complex

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Published Papers

This special issue is now open for submission.
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