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Effects of Whole Grain and Dietary Fiber on Cardiometabolic Health

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A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutritional Epidemiology".

Deadline for manuscript submissions: 5 May 2024 | Viewed by 5652

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Special Issue Editors

Dr. Xin Liu

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Guest Editor

Key Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, Department of Epidemiology and Biostatistics, Global Health Institute, School of Public Health, Xi’an Jiaotong University Health Science Center, 76 West Yanta Road, Xi’an 710061, China
Interests: weight control; precision nutrition; genetics; metabolomics; diabetes; cardiometabolic diseases

Dr. Liang Sun

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Guest Editor

School of Public Health, Fudan University, Shanghai 200032, China
Interests: nutritional epidemiology; nutritional intervention; precision nutrition; cardiometabolic disease

Dr. Lin Shi

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Guest Editor

School of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi’an 710119, China
Interests: metabolomics; metagenomics; food and nutrition science; R programming

Special Issue Information

Dear Colleagues,

Grains are widely consumed all over the world as they provide calories, macronutrients, micronutrients, dietary fibers, minerals, and plenty of phytochemicals that may have prolonged effects on human metabolism. Epidemiology studies have indicated prospective positive associations between refined grain consumption and elevated risks of diabetes, cardiovascular diseases, cancer, and total mortality, while others have suggested the protective effects of whole grain consumption. Interestingly, biological experiment models have highlighted the effects of metabolomic profiles and their interactions with gut microbiota on host cardiovascular health, such as blood pressure regulation, glucose metabolism, etc. In this regard, it will be of great value to understand the influence of grain consumption on the human metabolome, gut microbiota metabolites, and their contributions, and how grain consumption modulates cardiovascular health and clinical metabolic health. This Special Issue is aimed at providing the most advanced original results on the role of host metabolomic profiles/gut microbiota profiles, on the associations between grain consumption and cardiometabolic outcomes, and the intervention effects of grain modulations on cardiometabolic outcomes. We encourage human prospective studies and randomized controlled trials, but cross-sectional human studies and animal model studies with sufficient novelty will also be considered. Potential topics include, but are not limited to:

Effects of refined/whole grain consumption on the metabolome and diabetes;

Effects of refined/whole grain consumption on the metabolome and body composition;

Effects of refined/whole grain consumption on the metabolome and cardiovascular disease;

Effects of refined/whole grain consumption on gut microbiota and diabetes;

Effects of refined/whole grain consumption on gut microbiota and body composition;

Effects of refined/whole grain consumption on gut microbiota and cardiovascular disease.

Dr. Xin Liu
Dr. Liang Sun
Dr. Lin Shi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

grain intake
metabolomics
gut microbiota
cardiovascular health
metabolic disease

Published Papers (3 papers)

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Editorial

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3 pages, 204 KiB

Open AccessEditorial

Grain Intake and Cardiometabolic Health—Towards Precision Nutrition

by Xin Liu, Lin Shi and Liang Sun

Nutrients 2023, 15(21), 4605; https://doi.org/10.3390/nu15214605 - 30 Oct 2023

Viewed by 1264

Abstract

Grains are widely consumed all over the world, providing calories, macronutrients, micronutrients, dietary fiber, minerals, and plenty of phytochemicals [...] Full article

(This article belongs to the Special Issue Effects of Whole Grain and Dietary Fiber on Cardiometabolic Health)

Research

Jump to: Editorial

13 pages, 247 KiB

Open AccessArticle

Association of Dietary Resistant Starch Intake with Obesity and Metabolic Syndrome in Korean Adults

by Min-Sook Kang, Kyeong-A Jang, Haeng-Ran Kim and SuJin Song

Nutrients 2024, 16(1), 158; https://doi.org/10.3390/nu16010158 - 03 Jan 2024

Viewed by 1005

Abstract

Research findings on the relationship between dietary resistant starch (RS) intake and metabolic diseases using population-based data are very scarce. This study examined the association of dietary RS intake with obesity and metabolic syndrome in Korean adults. A total of 12,491 adults (5292 men and 7199 women) were selected from the 2016–2018 Korea National Health and Nutrition Examination Survey data. The individual RS intake (g) was calculated by linking the 1-day 24 h recall data with the RS content database for common Korean foods. Obesity was defined as a BMI ≥ 25.0 kg/m². Metabolic syndrome was defined as having three or more of the following: abdominal obesity, elevated triglycerides, low HDL cholesterol, elevated fasting blood glucose, and elevated blood pressure. Odds ratios (ORs) with 95% confidence intervals (CIs) for obesity and metabolic syndrome across quartiles (Qs) of RS intake were calculated using multiple logistic regression analysis. In men, the highest quartile of RS intake showed a significantly lower OR for metabolic syndrome compared to the lowest quartile after adjusting for covariates (OR = 0.71, 95% CI = 0.56–0.92, p-trend = 0.0057). Dietary RS intake in men was also inversely associated with obesity (Q4 vs. Q1: OR = 0.80, 95% CI = 0.67–0.97, p-trend = 0.0329) and elevated triglycerides (Q4 vs. Q1: OR = 0.80, 95% CI = 0.66–0.98, p-trend = 0.0314). In women, RS intake was not associated with metabolic syndrome. Our findings may serve as useful data for developing guidelines for RS intake and conducting further cohort and clinical studies to investigate the health effects of RS. Full article

(This article belongs to the Special Issue Effects of Whole Grain and Dietary Fiber on Cardiometabolic Health)

15 pages, 7824 KiB

Open AccessArticle

The Short-Term Variation of Human Gut Mycobiome in Response to Dietary Intervention of Different Macronutrient Distributions

by Yunyi Tian, Wanglong Gou, Yue Ma, Menglei Shuai, Xinxiu Liang, Yuanqing Fu and Ju-Sheng Zheng

Nutrients 2023, 15(9), 2152; https://doi.org/10.3390/nu15092152 - 29 Apr 2023

Cited by 2 | Viewed by 2510

Abstract

While the human gut is home to a complex and diverse community of microbes, including bacteria and fungi, research on the gut microbiome has largely focused on bacteria, with relatively little attention given to the gut mycobiome. This study aims to investigate how diets with different dietary macronutrient distributions impact the gut mycobiome. We investigated gut mycobiome response to high-carbohydrate, low-fat (HC) and low-carbohydrate high-fat (LC) diet interventions based on a series of 72-day feeding-based n-of-1 clinical trials. A total of 30 participants were enrolled and underwent three sets of HC and LC dietary interventions in a randomized sequence. Each set lasted for 24 days with a 6-day washout period between dietary interventions. We collected and analyzed the fungal composition of 317 stool samples before and after each intervention period. To account for intra-individual variation across the three sets, we averaged the mycobiome data from the repeated sets for analysis. Of the 30 participants, 28 (aged 22–34 years) completed the entire intervention. Our results revealed a significant increase in gut fungal alpha diversity (p < 0.05) and significant changes in fungal composition (beta diversity, p < 0.05) after the HC dietary intervention. Specifically, we observed the enrichment of five fungal genera (Pleurotus, Kazachstania, Auricularia, Paraphaeosphaeria, Ustilaginaceae sp.; FDR < 0.052) and depletion of one fungal genus (Blumeria; FDR = 0.03) after the HC intervention. After the LC dietary intervention, one fungal genus was enriched (Ustilaginaceae sp.; FDR = 0.003), and five fungal genera were depleted (Blumeria, Agaricomycetes spp., Malassezia, Rhizopus, and Penicillium; FDR < 0.1). This study provides novel evidence on how the gut mycobiome structure and composition change in response to the HC and LC dietary interventions and reveals diet-specific changes in the fungal genera. Full article

(This article belongs to the Special Issue Effects of Whole Grain and Dietary Fiber on Cardiometabolic Health)

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