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Nutrients
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Vitamins, Minerals, and Cardiometabolic Health
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Vitamins, Minerals, and Cardiometabolic Health

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Micronutrients and Human Health".

Deadline for manuscript submissions: closed (15 December 2025) | Viewed by 3382

Special Issue Editor

Dr. Kenneth Ka-Hei Lo

E-Mail Website
Guest Editor
Department of Food Science and Nutrition, Hong Kong Polytechnic University, Kowloon, Hong Kong
Interests: dietary pattern; nutritional epidemiology; cardiometabolic diseases; cognitive health
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Population ageing is related to the increasing cardiometabolic disease burden worldwide, including diabetes, hypertension, obesity, dyslipiemia, cardiovascular disease, and metabolic syndrome. Vitamins and minerals are nutrients that our bodies use in very small amounts for a variety of metabolic processes, and they are the key determinants of cardiometabolic health.

The objective of this Special Issue on ‘Vitamins, Minerals, and Cardiometabolic Health’ is to publish updated research evidence that examined the roles of vitamins and minerals in improving various cardiometabolic health, both in the general population or in at-risk individuals. This Special Issue welcomes multiple types of human studies, namely observational studies, intervention studies, systematic reviews, and meta-analysis.

Dr. Kenneth Ka-Hei Lo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • vitamins
  • minerals
  • nutritional epidemiology
  • cardiometabolic
  • cohort studies
  • meta-analyses

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Published Papers (2 papers)

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Research

15 pages, 598 KB  
Article
Hair Silicon as a Long-Term Mineral Exposure Marker in Coronary Artery Disease: A Pilot Study
by Ewelina A. Dziedzic, Łukasz Dudek, Andrzej Osiecki, Jakub S. Gąsior and Wacław Kochman
Nutrients 2025, 17(24), 3956; https://doi.org/10.3390/nu17243956 - 18 Dec 2025
Viewed by 946
Abstract
Background: Coronary artery disease (CAD) is a multifactorial atherosclerotic disorder. Silicon (Si) is a trace mineral with potential antioxidant, anti-inflammatory, and lipid-modulating effects, but its clinical relevance in cardiovascular disease remains unclear. This study evaluated whether hair Si concentration—reflecting long-term exposure—is associated [...] Read more.
Background: Coronary artery disease (CAD) is a multifactorial atherosclerotic disorder. Silicon (Si) is a trace mineral with potential antioxidant, anti-inflammatory, and lipid-modulating effects, but its clinical relevance in cardiovascular disease remains unclear. This study evaluated whether hair Si concentration—reflecting long-term exposure—is associated with CAD severity, clinical phenotype, risk factors, and systemic inflammation. Methods: A total of 130 patients with angiographically confirmed CAD (N = 36, 28% women) who met the inclusion criteria were enrolled. Disease severity was quantified using the Coronary Artery Surgery Study Score (CASSS) and SYNTAX score. Hair Si concentration was determined by inductively coupled plasma optical emission spectrometry (ICP-OES). Associations with demographic, clinical, biochemical, and inflammatory parameters were analyzed using non-parametric tests and multivariable ordinal logistic regression. Results: Median hair Si concentration was 21.3 ppm (range: 0.7–211.0). Hair Si levels showed no significant differences across CAD severity assessed by CASSS (H = 2.51; p = 0.47) or SYNTAX score (r = 0.079; p = 0.37). Similarly, no differences were observed between patients with stable angina and those presenting with acute coronary syndrome (p = 0.57) or between individuals with and without prior myocardial infarction. Hair Si concentration was unrelated to age, BMI, cardiovascular risk factors, lipid profile, or systemic inflammatory indices (all p > 0.2). Conclusions: Hair silicon concentration was not associated with CAD severity, phenotype, or systemic inflammation, suggesting that long-term Si exposure is metabolically neutral in advanced atherosclerosis. Unlike other minerals, silicon appears unlikely to serve as a diagnostic or prognostic biomarker in CAD, although its relevance may be confined to early vascular remodeling and primary prevention. Full article
(This article belongs to the Special Issue Vitamins, Minerals, and Cardiometabolic Health)
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19 pages, 295 KB  
Article
Metal Transporter Gene SLC39A8 Polymorphism rs13107325 and Dietary Manganese Intake Are Associated with Measures of Cardiovascular Disease Risk in a UK Biobank Population Cohort
by Riju Sigdel, Parker R. Johnson, Gracie E. Meade, Aiden Y. Kim, Gracie M. Maschmeier, Edralin A. Lucas, McKale R. Montgomery, Dingbo Lin, Sam R. Emerson and Winyoo Chowanadisai
Nutrients 2025, 17(19), 3031; https://doi.org/10.3390/nu17193031 - 23 Sep 2025
Viewed by 2069
Abstract
Background/Objectives: Metal transporter gene SLC39A8 and single nucleotide polymorphism (SNP) rs13107325 are associated with risk factors for atherosclerosis and cardiovascular disease (CVD). However, it is unclear how dietary manganese intake impacts CVD risk factors. The aim of this study was to use the [...] Read more.
Background/Objectives: Metal transporter gene SLC39A8 and single nucleotide polymorphism (SNP) rs13107325 are associated with risk factors for atherosclerosis and cardiovascular disease (CVD). However, it is unclear how dietary manganese intake impacts CVD risk factors. The aim of this study was to use the UK Biobank population cohort (276,436 participants, Caucasian genetic ancestry, no genetic kinship) to investigate whether rs13107325 and dietary manganese are associated with CVD risk. Methods: A cross-sectional design and quantile (median) regression was used to determine associations of rs13107325 and dietary manganese intake with indicators of CVD risk. Results: SNP rs13107325 was associated with CVD risk factors, including greater body mass index (BMI) (beta ± SE per rs13107325 allele = 0.283 ± 0.0392, false discovery rate (FDR) < 10−10) and triglycerides (beta ± SE = 0.0308 ± 0.00761, FDR < 0.001) and reduced high density lipoprotein (HDL) (beta ± SE = −0.0298 ± 0.00343, FDR < 10−15). SNP rs13107325 was also associated with lower systolic (beta ± SE = −0.601 ± 0.172, FDR < 10−3) and diastolic blood pressure (beta ± SE = −0.531 ± 0.100, FDR < 10−5). Dietary manganese intake was positively correlated with measures of favorable cardiovascular health, such as lower BMI (beta ± SE per mg dietary manganese = −0.531 ± 0.0118, FDR < 10−300), reduced triglycerides (beta ± SE = −0.0451 ± 0.00229, FDR < 10−50), increased HDL (beta ± SE = 0.00958 ± 0.00103, FDR < 10−15), and lower blood pressure (systolic beta ± SE = −0.529 ± 0.0520, FDR < 10−20; diastolic beta ± SE = −0.562 ± 0.0302, FDR < 10−50). Conclusions: The favorable associations of dietary manganese opposed many deleterious trends associated with rs13107325. Increased dietary manganese may promote cardiovascular health and offset many risks to cardiovascular health linked to SNP rs13107325. Full article
(This article belongs to the Special Issue Vitamins, Minerals, and Cardiometabolic Health)
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