Nutrition and Obesity: From Mechanisms to Clinical Implications

Dear Colleagues,

We are pleased to announce the launch of the Special Issue entitled “Nutrition and Obesity: From Mechanisms to Clinical Implications”, to be published in the journal Nutrients.

Obesity continues to represent a major global public health challenge and is a key contributor to cardiometabolic disorders, including type 2 diabetes (T2D), cardiovascular disease, dyslipidemia, metabolic dysfunction-associated steatotic liver disease/steatohepatitis (MASLD/MASH), and several forms of cancer. In recent years, remarkable progress has been made in elucidating the biological mechanisms underlying obesity, as well as in translating this knowledge into innovative preventive and therapeutic strategies. Nevertheless, despite these advances, the global obesity epidemic shows no clear signs of abating.

This Special Issue aims to bridge fundamental mechanisms with clinical and public health implications, highlighting the complex interplay between nutrition, metabolism, and obesity-related diseases. This new volume seeks to further strengthen Nutrients as a leading platform for high-quality research that advances both mechanistic understanding and clinical application in the field of nutrition and obesity.

We invite the submission of original research articles and comprehensive reviews addressing all aspects of obesity research, from molecular pathways to clinical and population-based interventions.

Topics of interest include, but are not limited to, the following:

• Nutritional Epidemiology: Studies on dietary patterns, macronutrient and micronutrient intake, and their associations with obesity and metabolic disorders.
• Mechanisms of Obesity: Research exploring physiological, biochemical, molecular, and genetic pathways linking nutrition to obesity and related comorbidities.
• Obesity-Associated Inflammation: Investigations into chronic low-grade inflammation, immune–metabolic interactions, and the modulation of inflammatory responses by dietary factors.
• Dietary Interventions: Clinical and translational studies evaluating dietary strategies for obesity prevention and treatment, including low-carbohydrate, low-fat, Mediterranean, and balanced diets.
• Intermittent Fasting and Time-Restricted Eating: Evidence on efficacy, safety, and underlying mechanisms of different fasting regimens.
• Innovative Technologies: Applications of artificial intelligence, digital health tools, mobile apps, and wearable devices in obesity research and clinical management.
• Public Health Nutrition: Population-based strategies, policy interventions, and community programmes aimed at promoting healthy eating and reducing obesity prevalence.
• Lifestyle Factors: The role of physical activity, sleep, and behavioural factors in obesity development and treatment.
• Childhood Obesity: Early life nutrition, environmental and familial influences, preventive strategies, and long-term health outcomes.
• Nutrigenomics and Personalized Nutrition: Gene–diet interactions and their implications for precision nutrition and personalized obesity management.
• Socioeconomic and Cultural Determinants: The influence of socioeconomic status, culture, and the built environment on dietary behaviours and obesity risk.
• Innovative Nutritional Products: Development and clinical evaluation of functional foods, supplements, and novel nutritional approaches targeting obesity.
• Body Composition Assessment: The role of body composition analysis in the clinical evaluation and monitoring of individuals living with obesity.

We look forward to receiving your valuable contributions and to advancing the field through high-quality research that connects mechanistic insights with clinical and public health applications in nutrition and obesity.

Dr. Javier Gómez-Ambrosi
Dr. Victoria Catalán
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• obesity
• obesity-associated comorbidities
• adipose tissue dysfunction
• adipokines
• artificial intelligence in obesity research and treatment
• dietary treatment
• lifestyle intervention
• pharmacological treatment
• metabolic surgery
• intermittent fasting
• cardiometabolic risk improvement
• body composition changes
• weight regain
• predictors of treatment success
• use of apps for weight loss
• treatment of children and adolescents